Table of modes of mechanical ventilation

Modes of mechanical ventilation refers to the methods a Ventilator offers to assist or replace spontaneous breathing.[1] Modern Ventilators provide a number of such Modes (derived from Modus operandi) to enable the most suitable respiratory support for the individual patient.[2] Each Mode has its particular set of Controls to adapt the breath delivery to the patient. CAVEAT: Although manufacturers may offer identical breath delivery methods, the names of the Modes may be different[3].

## Contents

* 1 Overview
* 2 Basic Modes
* 2.1 Definition of terms
* 2.1.1 Start of inhalation (Trigger)
* 2.1.2 Inhalation and breath delivery
* 2.1.3 Start of exhalation (Cycling)
* 2.1.4 Exhalation
* 2.2 Table of Basic Modes and their acronyms
* 3 Dual Control Modes
* 3.1 Table of Dual Control Modes and their acronyms
* 4 Adaptive Modes
* 4.1 Adaptive Support Ventilation (ASV) and Adaptive Ventilation Mode (AVM)
* 4.2 INTELLiVENT-ASV
* 4.3 SmartCare/PS
* 5 See also
* 6 References

## Overview

Commercially available ventilators offer different Modes of breath delivery, each with its particular set of control knobs. Breath delivery methods and terminology are not standardized can be quite confusing.[3] However, by and large, they can be grouped into Basic Modes, Dual Control Modes and Adaptive Modes.[4] Three tables are provided below to illustrate these three groups.

NOTE: not all controls on a ventilator are part of a Mode, for example alarm settings and monitoring values are used independent of the Mode. Also, the control to set the percentage oxygen (fraction of inspired oxygen, FiO2) is not part of a Mode.[1]

## Basic Modes

In the basic breath delivery Modes, the ventilator acts as a high-fidelity delivery device. The clinician's settings are direct commands to the inspiratory and expiratory valve controls. The ventilator uses fast sensors for intra-breath control to match the clinicians settings exactly. Breath delivery follows the phases of breathing,[5] i.e., inhalation and exhalation. Each Mode defines how breath delivery and timing can be controlled by the clinician.[1]

### Definition of terms

#### Start of inhalation (Trigger)

The start of inhalation is initiated either by the machine or the patient and that point in time is called Inspiratory Trigger. The ventilator needs to know when to start delivering gas to the patient. If the patient does not breathe at all, a timer starts inhalation. If the patient has some breathing activity, the ventilator can sense this effort by measuring pressure or flow and start inhalation if pressure or flow drop below a certain threshold. That threshold is called Trigger Sensitivity. Thus, the controls available to the clinician are respiratory rate and trigger sensitivity.

NOTE: Trigger sensitivity plays a double role. Evidently, it determines the start of inhalation and, by the same toke, it ends expiration. For example, if trigger sensitiviy is set too sensive, it may influence respiratory rate and create tachypnea.[6]

#### Inhalation and breath delivery

Once the ventilators is triggered to deliver respiratory gas, two methods to deliver the gas mixture are technically possible: flow controlled or pressure controlled[7] gas gelivery. Both methods have their advantages and disadvantages. If flow controlled gas delivery is chosen, it is often combined with a Volume limit which stops gas delivery when a set volume is reached. Thus, the term Volume Controlled Ventilation is often used. The controls available to the clinician are inspiratory pressure, inspiratory flow and/or inspiratory volume.

#### Start of exhalation (Cycling)

Inhalation must eventually stop and cycle to exhalation to enable the lungs to exhale. If the patient does not breathe, the ventilator must switch to exhalation after a pre-set time (time cycled) has elapsed, a certain pressure is exceeded (pressure cycled) or a pre-set volume (volume cycled) has been delivered.[1] If the patient has some breathing activity, the ventilator can sense this by measuring flow and start exhalation, for example, if flow drops below a certain threshold. That threshold may be termed "Expiratory Trigger Sensitivity". The controls available to the clinician are inspiratory time, inspiratory volume, inspiratory flow, maximum pressure and/or expiratory trigger sensitivity.

NOTE: Inspiratory flow can be expressed as V'I = Vt/Ti and respiratory rate f = 60/(Ti+Te). Both formulas have three variables and two degrees of freedom. This means that only two variables can be controlled independently, the third variable follows.

#### Exhalation

Emtpying the lungs requires time which starts with the onset of exhalation and ends with the start of the subsequent inhalation. If the patient is passive, the exhalation is terminated by a timer. If the patient has some breathing activity, exhalation may be terminated by the subsequent inhalation effort of the patient. Controls include a selection of expiratory time, respiratory rate and/or trigger sensitivity.

NOTE: The pressure maintained throughout exhalation is termed Positive End-Expiratory Pressure PEEP. CPAP differs from PEEP because the patient can inhale and exhale in CPAP.

### Table of Basic Modes and their acronyms

The table below lists the working principles of some of the common Modes of ventilation.

* Breath delivery mechanism: Flow means that the ventilator controls the valve to maintain a set flow independent of pressure or volume. Pressure means that the ventilator maintains a set pressure, independent of flow and volume.
* Trigger: start of inhalation
* Cycling: start of exhalation
* Vent means controlled by ventilator based on settings by clinician.
* Pat means controlled by patient, based on measurements of flow , pressure or muscle activity.[8]

Mode examples, not exhaustive!  | Trigger  | Breath Delivery

Mechanism

| Cycling  | Remark

|
|
|
|

Volume Controlled Ventilation, VC CMV, VCV, A/C  | Vent or Pat  | Flow  | Vent  | Clinicians sets tidal volume, flow waveform and timing. Ventilator adjusts the valves to deliver that exact volume irrespective of changing resitance and compliance of the patient.[4]
Pressure Controlled Ventilation PC  | Vent or Pat  | Pressure  | Vent  | Clinician sets a pressure trajectory (inspiratory pressure level and inspiratory time). Ventilator uses a pressure transducer to servo-control the valve, creating the desired pressure wave (usually a square wave) at the airway opening.[9]
Synchronized Intermittent Mandatory Ventilation SIMV (volume cycled)  | Vent or Pat  | Flow (mandatory breath) or Pressure (spontaneous breath)  | Vent or Pat  | Combination of VC and PS. Basis is Volume Controlled Ventilation. Patient can take breaths in between.
Synchronized Intermittent Mandatory Ventilation SIMV (pressure limited)  | Vent or Pat  | Pressure  | Vent or Pat  | Combination of PC and PS. Basis is Volume Controlled Ventilation. Patient can take breaths in between.
Continuous Positive Airway Pressure CPAP  | Pat  | Pressure  | Pat  | Ventilator maintains a set pressure (PEEP) independent of patient effort.
Pressure Support PS  | Pat  | Pressure  | Pat  | Clinician sets a pressure level. The control loop is identical to PCV for maintaining pressure, but breath cycling is determined by patient flow decay.[10] The level of support is fixed until changed by the clinician.
Airway Pressure Release Ventilation, APRV, Bilevel Positive Airway Pressure, BiPAP, DuoPAP  | Vent or Pat  | Pressure  | Vent or Pat  | Clinician sets two levels of pressure and the time to switch between the two. Ventilator maintains each level independet of patient effort. Patient can breathe on both levels.
Proportional Assist Ventilation PAV[8] | Pat  | Pressure  | Pat  | Advanced basic mode. Clinician sets a fixed degree of support (assist %) rather than a pressure level. Pressure level is calculated by ventilator as a proportion of delivered volume and flow.[11]
Neurally Adjusted Ventilation Assist NAVA[8] | Pat  | Pressure  | Pat  | The diaphragm's electrical activity (EAdi) is the commanding waveform; the ventilator delivers pressure in proportion to the EAdi signal with a fixed gain set by the clinician.[12]

PAV and NAVA were designed to provide superior synchrony with the patient's breathing by using a physiological signal as the command source.

## Dual Control Modes

Dual Control Modes introduce an outer control loop that wraps around a Basic Mode. The clinician sets a performance target (for example Vt and respiratory rate) and the ventilator then uses a Basic Mode (usually a pressure-controlled or pressure-support breath) as its actuator and automatically adjusts the pressure level from breath to breath to meet the performance target.

This represents a significant user-interface advantage. The clinician can manage the fundamental goals of ventilation—for example tidal volume or respiratory rate —while the machine handles the technical translation into the required pressure, adapting automatically to changes in the patient's respiratory system compliance and resistance and spontaneous activity.[13]

### Table of Dual Control Modes and their acronyms

The table below lists the working principles of some of the Dual Control Modes. The clinician set a desired target, for example the tidal volume Vt and the ventilator adjusts one of the variables of provided by the basic mode it uses.[14]

* The Target Variable is set by the clinician and fixed.
* The Controlled Variable is adjusted by the ventilator to achieve the Target Value.

Mode examples, not exhaustive!  | Underlying Basic Mode  | Target Variable  | Controlled Variable  | Remark

|
|
|
|

Pressure-Regulated Volume Control PRVC, VC+, AutoFlow  | Pressure Controlled  | Tidal volume  | Inspiratory pressure  | Ventilator operates in a Pressure Control (Basic Mode) scheme. After each mandatory breath, it compares the delivered Vt to the clinician-set target Vt. It then adjusts the inspiratory pressure level for the next mandatory breath upward or downward.[13]
Volume Support VS  | Pressure Supported  | Tidal volume  | Pressure support level  | This is the Targeted Spontaneous Mode counterpart to PRVC. It uses Pressure Support (Basic Mode) as its actuator. After each spontaneous breath, ventilator adjusts the PS level for the subsequent breath to achieve the set Vt target.[15]
Mandatory Rate Ventilation MRV  | Pressure Supported  | Respiratory Rate  | Pressure support level  | This is the Respiratory Rate counterpart to VS. Uses Pressure Support (Basic Mode) as its actuator. After each spontaneous breath, ventilator adjusts the PS level for the subsequent breath to achieve the set Respiratory Rate target.[16]
Mandatory Minute Ventilation MMV  | Pressure Supported  | Minute Ventilation  | Number of Mandatory Breaths  | Ventilator provides a spontaneous Mode with or without inspiratory support set by the clinician. Clinician also sets desired Minute Ventilation MVtarget. The ventilator monitors Minute Ventilation taken by the patient (MVpat). If MVpat drops below MVtarget, ventilator provides a VC breath to the patient with volume and timing as preset by the clinican.[17]
Volume Assured Pressure Support Ventilation VAPSV  | Pressure Control and Volume Control  | Tidal Volume  | Pressure support level plus volume add  | This Mode represents intra-breath target enforcement. Ventilator primarily delivers Pressure Support (Basic Mode). Within the ongoing inspiratory phase, if the algorithm predicts that the decaying flow of the PS breath will not meet the set Vt target, ventilator automatically switches the control logic to a Volume Control (Basic Mode) waveform for the remainder of that breath to guarantee the volume. This is sophisticated targeting, but the goal remains achieving the clinician's predefined Vt.[18]
Automode  | Selectable Mode 1 and Mode 2  | Switching criterium  | Mode 1 or Mode 2  | This is a Mode-manager that operates on top of dual control modes. It pairs two Dual Control Modes (e.g., PRVC and VS) and ventilator automatically switches between them based on the presence or absence of patient triggering, all while maintaining the clinician-set volume targets.[19]

## Adaptive Modes

Adaptive Modes employ a supervisory control layer that automates the treatment strategy. The clinician inputs a high-level goal (typically Minute Ventilation or blood gas values), and the ventilator assumes responsibility for setting the intermediate performance targets (like Vt and RR plus PEEP and FiO2) and adjusting them over time based on measurements of the patient's pathology (airways resistance, lung elastance, spontaneous breathing, gas exchange).[20]

### Adaptive Support Ventilation (ASV) and Adaptive Ventilation Mode (AVM)

The mechanism of these Modes is called cascaded adaptive control.[21] In ASV, the clinician inputs the patient's ideal body weight and a percent minute ventilation (%MinVol). The clinician does not set a specific Vt or RR, this is done by the ventilator algorithm as follows. The ventilator continuously measures the expiratory time constant (a product of compliance and resistance). Using the "minimum work of breathing" mathematical model,[22] it autonomously calculates and sets the optimal combination of Respiratory Rate RR and tidal volume Vt for the measured mechanics. It then uses its internal SIMV algorithm (a Targeted Mode) to deliver breaths meeting these self-determined targets.[23] AVM follows the same principle with different target optimisation.[20]

### INTELLiVENT-ASV

The mechanism of this mode extends ASV by adding integrated closed-loops for both ventilation (adjusting the %MinVol target based on end-tidal CO₂) and oxygenation (adjusting PEEP and FiO₂ based on SpO₂). It represents full, multi-parameter adaptation to the patient's gas exchange and mechanical pathology.[24]

### SmartCare/PS

The mechanism of this Mode was developed using an expert systems approach.[25] SmartCare/PS can be viewed as a supervisory weaning system. The clinician sets criteria for a stable, wean-ready pattern (e.g., Vt, RR ranges). The system monitors the patient over a window of time (hours). If the patient remains within the "stable zone," it automatically reduces the PS level; if the patient struggles, it increases support.[26] It adapts a heuristic weaning strategy to the patient's resolving respiratory pathology to reduce ventilatory support automatically.

## See also

* Respiratory therapy

## References

1. ↑ 1.0 1.1 1.2 1.3 Cairo, J.M. (2020). Pilbeam's Mechanical Ventilation. Physiological and clinical applications.. St. Louis, Missouri: Elsevier. pp. 62ff. ISBN 978-0-323-87164-8.
2. ↑ "Modes of mechanical ventilation and weaning. A national survey of Spanish hospitals. The Spanish Lung Failure Collaborative Group.". Chest 106 (4): 1188–93. 1994. doi:10.1378/chest.106.4.1188. PMID 7924494.
3. ↑ 3.0 3.1 Adams, Alexander B. (2012). "Too many ventilator modes!". Respiratory Care 57 (4): 653–654. doi:10.4187/respcare.01787. ISSN 0020-1324. PMID 22472503.
4. ↑ 4.0 4.1 Chatburn, Robert L (2007). "Classification of ventilator modes: update and proposal for implementation.". Respiratory Care 3 (3): 301–323.
5. ↑ Brunner, J.; Wolff, G.; Langenstein, H.; Cumming, G. (December 1985). "Reliable detection of inspiration and expiration by computer" (in en). International Journal of Clinical Monitoring and Computing 1 (4): 221–226. doi:10.1007/BF01720186. ISSN 0167-9945. PMID 3836286. http://link.springer.com/10.1007/BF01720186.
6. ↑ Gurevitch, Michael J.; Gelmont, David (1989). "Importance of trigger sensitivity to ventilator response delay in advanced chronic obstructive pulmonary disease with respiratory failure" (in en). Critical Care Medicine 17 (4): 354–359. doi:10.1097/00003246-198904000-00011. ISSN 0090-3493. PMID 2639663. http://journals.lww.com/00003246-198904000-00011.
7. ↑ Garnero, A.J.; Abbona, H.; Gordo-Vidal, F.; Hermosa-Gelbard, C. (2013). "Modos controlados por presión versus volumen en la ventilación mecánica invasiva" (in es). Medicina Intensiva 37 (4): 292–298. doi:10.1016/j.medin.2012.10.007. https://linkinghub.elsevier.com/retrieve/pii/S0210569112003166.
8. ↑ 8.0 8.1 8.2 Navalesi P, Costa R (2003). "New modes of mechanical ventilation: proportional assist ventilation, neurally adjusted ventilatory assist, and fractal ventilation.". Curr Opin Crit Care 9 (1): 51–8. doi:10.1097/00075198-200302000-00010. PMID 12548030.
9. ↑ Muñoz, Javier; Guerrero, Jose Eugenio; Escalante, Jose Luis; Palomino, Ricardo; La Calle, Braulio De (1993). "Pressure-controlled ventilation versus controlled mechanical ventilation with decelerating inspiratory flow" (in en). Critical Care Medicine 21 (8): 1143–1148. doi:10.1097/00003246-199308000-00012. ISSN 0090-3493. PMID 8339578. http://journals.lww.com/00003246-199308000-00012.
10. ↑ Brochard, Laurent (2013). Pressure support ventilation. In: Tobin MJ, ed. Principles and Practice of Mechanical Ventilation.. McGraw-Hill. ISBN 9780071736268.
11. ↑ Younes, Magdy (1992). "Proportional Assist Ventilation, a New Approach to Ventilatory Support: Theory". American Review of Respiratory Disease 145 (1): 114–120. doi:10.1164/ajrccm/145.1.114. ISSN 0003-0805. PMID 1731573. https://doi.org/10.1164/ajrccm/145.1.114.
12. ↑ Sinderby, Christer; Navalesi, Paolo; Beck, Jennifer; Skrobik, Yoanna; Comtois, Norman; Friberg, Sven; Gottfried, Stewart B.; Lindström, Lars (1999). "Neural control of mechanical ventilation in respiratory failure". Nature Medicine 5 (12): 1433–1436. doi:10.1038/71012. ISSN 1078-8956. PMID 10581089. https://doi.org/10.1038/71012.
13. ↑ 13.0 13.1 Guldager, Henrik; Nielsen, Soeren L; Carl, Peder; Soerensen, Mogens B (1997). "A comparison of volume control and pressure-regulated volume control ventilation in acute respiratory failure" (in en). Critical Care 1 (2). doi:10.1186/cc107. ISSN 1364-8535.
14. ↑ Troxell, David (2024-06-15). "Volume Targeted Algorithms. Are they a one-size-fits-all approach to noninvasive ventilation?". Journal of Mechanical Ventilation 5 (2): 69–79. doi:10.53097/jmv.10101. ISSN 2694-0450. https://doi.org/10.53097/jmv.10101.
15. ↑ Larraza, S.; Dey, N.; Karbing, D.S.; Jensen, J.B.; Nygaard, M.; Winding, R.; Rees, S.E. (2015-04-01). "A mathematical model approach quantifying patients' response to changes in mechanical ventilation: Evaluation in volume support". Medical Engineering & Physics 37 (4): 341–349. doi:10.1016/j.medengphy.2014.12.006. ISSN 1350-4533. PMID 25686673. https://iopscience.iop.org/article/10.1016/j.medengphy.2014.12.006.
16. ↑ Taniguchi, Corinne; Eid, Raquel C; Saghabi, Cilene; Souza, Rogério; Silva, Eliezer; Knobel, Elias; Paes, Ângela T; Barbas, Carmen S (2009-01-26). "Automatic versus manual pressure support reduction in the weaning of post-operative patients: a randomised controlled trial" (in en). Critical Care 13 (1). doi:10.1186/cc7695. ISSN 1364-8535. PMID 19171056.
17. ↑ Hewlett, A. M.; Platt, A. S.; Terry, V. G. (1977). "Mandatory minute volume: A new concept In weaning from mechanical ventilation" (in en). Anaesthesia 32 (2): 163–169. doi:10.1111/j.1365-2044.1977.tb11588.x. ISSN 0003-2409. https://associationofanaesthetists-publications.onlinelibrary.wiley.com/doi/10.1111/j.1365-2044.1977.tb11588.x.
18. ↑ Amato, Marcelo Britto Passos; Barbas, Carmen Silvia Valente; Bonassa, Jorge; Saldiva, Paulo Hilario Nascimento; Zin, Walter Araujo; de Carvalho, Carlos Roberto Ribeiro (1992). "Volume-Assured Pressure Support Ventilation (VAPSV)" (in en). Chest 102 (4): 1225–1234. doi:10.1378/chest.102.4.1225. PMID 1395773. https://linkinghub.elsevier.com/retrieve/pii/S0012369216343112.
19. ↑ Holt, SJ; Sanders, RC; Thurman, TL; Heulitt, TL (2001). "An evaluation of Automode, a computer-controlled ventilator mode, with the Siemens Servo 300A ventilator, using a porcine model". Respiratory Care 46 (1): 26–36.
20. ↑ 20.0 20.1 van der Staay, Matthias; Chatburn, Robert L. (2018). "Advanced modes of mechanical ventilation and optimal targeting schemes" (in en). Intensive Care Medicine Experimental 6 (1). doi:10.1186/s40635-018-0195-0. ISSN 2197-425X. PMC 6104409. https://icm-experimental.springeropen.com/articles/10.1186/s40635-018-0195-0.
21. ↑ Isermann, Rolf (1981). Digital control systems. Berlin Heidelberg New York: Springer. pp. 360ff. ISBN 978-3-540-10728-6.
22. ↑ Grodins, FS; Yamashiro, SM (1977). "Control of Ventilation". in West, John B.. Bioengineering aspects of the lung. 3. Marcel Dekker. pp. 547. ISBN 0-8247-6378-5.
23. ↑ Laubscher, T.P.; Heinrichs, W.; Weiler, N.; Hartmann, G.; Brunner, J.X. (1994). "An adaptive lung ventilation controller". IEEE Transactions on Biomedical Engineering 41 (1): 51–59. doi:10.1109/10.277271. http://ieeexplore.ieee.org/document/277271/.
24. ↑ Arnal, Jean-Michel; Garnero, Aude; Novonti, Dominik; Demory, Didier; Ducros, Laurent; Berric, Audrey; Donati, Stéphane Yannis; Corno, Gaëlle et al. (2013-09-11). "Feasibility study on full closed-loop control ventilation (IntelliVent-ASV™) in ICU patients with acute respiratory failure: a prospective observational comparative study" (in en). Critical Care 17 (5). doi:10.1186/cc12890. ISSN 1364-8535. PMC 4056360. https://ccforum.biomedcentral.com/articles/10.1186/cc12890.
25. ↑ Dojat, M; Harf, A; Touchard, D; Laforest, M; Lemaire, F; Brochard, L (1996). "Evaluation of a knowledge-based system providing ventilatory management and decision for extubation.". American Journal of Respiratory and Critical Care Medicine 153 (3): 997–1004. doi:10.1164/ajrccm.153.3.8630586. ISSN 1073-449X. https://doi.org/10.1164/ajrccm.153.3.8630586.
26. ↑ Lellouche, Francçois; Mancebo, Jordi; Jolliet, Philippe; Roeseler, Jean; Schortgen, Fréderique; Dojat, Michel; Cabello, Belen; Bouadma, Lila et al. (2006-10-15). "A Multicenter Randomized Trial of Computer-driven Protocolized Weaning from Mechanical Ventilation" (in en). American Journal of Respiratory and Critical Care Medicine 174 (8): 894–900. doi:10.1164/rccm.200511-1780OC. ISSN 1073-449X. https://www.atsjournals.org/doi/10.1164/rccm.200511-1780OC.

* v
* t
* e

Mechanical ventilation

Fundamentals|

* Modes of mechanical ventilation
* Mechanical ventilation in emergencies
* Nomenclature of mechanical ventilation

Modes|

* IMV/SIMV
* CMV
* ACV
* CSV
* PAP
* BPAP/NIV
* CPAP
* APRV
* MMV
* PAV
* ASV
* HFV

Related illness|

* ARDS
* Atelectotrauma
* Biotrauma
* Pulmonary barotrauma
* Pulmonary volutrauma
* Rheotrauma
* Ventilator-associated pneumonia
* Oxygen toxicity
* Ventilator-associated lung injury

Pressure|

* PEEP
* FiO2
* ΔP
* PIP
* PS
* PAW
* Pplat

Volumes|

* VT
* VE
* Vf

Other|

* Cdyn
* Cstatic
* PAO2
* VD/VT
* OI
* A-a gradient
* Mechanical power

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