Thyroid hormone resistance

Other names| Resistance to thyroid hormone
Regulation of thyroid hormone
Specialty| Endocrinology

Thyroid hormone resistance (also resistance to thyroid hormone (RTH), and sometimes Refetoff syndrome) describes a rare syndrome in which the thyroid hormone levels are elevated but the thyroid stimulating hormone (TSH) level is not suppressed, or not completely suppressed as would be expected. The first report of the condition appeared in 1967.[1] Essentially this is decreased end organ responsiveness to thyroid hormones.[2] A new term "impaired sensitivity to thyroid hormone" has been suggested in March 2014 by Refetoff et al.[3]

## Contents

* 1 Presentation
* 2 Causes
* 3 Regulation of thyroid hormone secretion
* 4 Diagnosis
* 5 Management
* 6 Incidence
* 7 References
* 8 External links

## Presentation

The syndrome can present with variable symptoms, even between members of the same family harboring the same mutation.[1] Typically most or all tissues are resistant to thyroid hormone, so despite raised measures of serum thyroid hormone the individual may appear euthyroid (have no symptoms of over- or underactivity of the thyroid gland). The most common symptoms are goiter and tachycardia. It has also been linked to some cases of attention deficit hyperactivity disorder (ADHD), although the majority of people with that diagnosis have no thyroid problems.[4] An association with depression has been proposed.[5]

## Causes

Normal thyroid hormone function requires normal thyroid hormone transport across cell membrane, appropriate deiodination, thyroid hormone nuclear receptor, thyroid hormone response elements, co-activators, co-repressors, and normal histone acetylation. Any abnormalities in this chain can result in thyroid hormone resistance and it has not been as well studied as the various forms of insulin resistance.[citation needed]

The most well known cause of the syndrome are mutations of the β (beta) form (THRB gene) of the thyroid hormone receptor, of which over 100 different mutations have been documented.[6] Mutations in MCT8 and SECISBP2 have also been associated with this condition.[7]

## Regulation of thyroid hormone secretion

Hypothalamus secretes a hormone called thyrotropin releasing hormone (TRH) which in turn release thyroid stimulating hormone (TSH). TSH signals thyroid to secrete thyroid hormones thyroxine (T4) and triiodothyronine (T3). T4 gets converted to active T3 in peripheral tissues with the help of deiodinase enzymes. T3 negatively feedback on the pituitary and decreases TSH secretion.[citation needed]

## Diagnosis

The characteristic blood test results for this disorder can also be found in other disorders (for example TSH-oma (pituitary adenoma), or other pituitary disorders). The diagnosis may involve identifying a mutation of the thyroid receptor, which is present in approximately 85% of cases.[8]

## Management

Beta blockers, like metoprolol, are sometimes used to help suppress symptoms.[citation needed]

## Incidence

Thyroid hormone resistance syndrome is rare, incidence is variously quoted as 1 in 50,000 or 1 in 40,000 live births.[9] More than 1000 individuals have been identified with thyroid hormone resistance, of which 85% had thyroid hormone beta receptor mutation.[7]

## References

1. ↑ 1.0 1.1 "Familial syndrome combining deaf-mutism, stuppled epiphyses, goiter and abnormally high PBI: possible target organ refractoriness to thyroid hormone". J. Clin. Endocrinol. Metab. 27 (2): 279–94. 1967. doi:10.1210/jcem-27-2-279. PMID 4163616.
2. ↑ "Approach to the patient with resistance to thyroid hormone and pregnancy". J. Clin. Endocrinol. Metab. 95 (7): 3094–102. 2010. doi:10.1210/jc.2010-0409. PMID 20610605.
3. ↑ "Classification and proposed nomenclature for inherited defects of thyroid hormone action, cell transport, and metabolism". Eur Thyroid J 3 (1): 7–9. March 2014. doi:10.1159/000358180. PMID 24847459.
4. ↑ "Attention deficit-hyperactivity disorder in people with generalized resistance to thyroid hormone". N. Engl. J. Med. 328 (14): 997–1001. 1993. doi:10.1056/NEJM199304083281403. PMID 8450877. https://iris.unito.it/bitstream/2318/1646358/1/hauser et al.1993.pdf.
5. ↑ "Refractory depression in a patient with peripheral resistance to thyroid hormone (RTH) and the effect of triiodothyronine treatment". Endocrine 31 (3): 272–8. June 2007. doi:10.1007/s12020-007-0042-7. PMID 17906375.
6. ↑ "Thyroid hormone resistance caused by a novel deleterious variant of the thyroid hormone receptor beta gene". Eur. J. Obstet. Gynecol. Reprod. Biol. 167 (1): 118–9. March 2013. doi:10.1016/j.ejogrb.2012.11.001. PMID 23195042.
7. ↑ 7.0 7.1 "Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination". Best Pract. Res. Clin. Endocrinol. Metab. 21 (2): 277–305. 2007. doi:10.1016/j.beem.2007.03.005. PMID 17574009.
8. ↑ "Thyroid hormone resistance without mutations in thyroid hormone receptor beta". Med. Sci. Monit. 13 (6): CS67–70. 2007. doi:10.12659/MSM.484143. PMID 17534237.
9. ↑ "Follow-up of newborns with elevated screening T4 concentrations". J. Pediatr. 143 (3): 296–301. September 2003. doi:10.1067/S0022-3476(03)00184-7. PMID 14517508.

## External links

Classification|

* ICD-10: E07
* ICD-9-CM: 246.8
* OMIM: 274300 Online Mendelian Inheritance in Man (OMIM) 188570
* MeSH: D018382
* DiseasesDB: 31913

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External resources|

* Orphanet: 3221

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