Timeline of vaccines

This is a timeline of the development of prophylactic human vaccines. Early vaccines may be listed by the first year of development or testing, but later entries usually show the year the vaccine finished trials and became available on the market. Although vaccines exist for the diseases listed below, only smallpox has been eliminated worldwide. The other vaccine-preventable illnesses continue to cause millions of deaths each year.[1] Currently, polio and measles are the targets of active worldwide eradication campaigns.

## Contents

* 1 18th century
* 2 19th century
* 3 20th century
* 4 21st century
* 5 See also
* 6 Sources

## 18th century

* 1797 Edward Jenner develops and documents first vaccine for smallpox (the first vaccine ever developed in history)

## 19th century

* 1884 First vaccine for cholera
* 1885 First vaccine for rabies by Louis Pasteur and Émile Roux[2]
* 1890 First vaccine for tetanus (serum antitoxin)
* 1896 First vaccine for typhoid fever
* 1897 First vaccine for bubonic plague

## 20th century

* 1921 First vaccine for tuberculosis
* 1923 First vaccine for diphtheria
* 1924 First vaccine for scarlet fever
* 1924 First vaccine for tetanus (tetanus toxoid, TT)
* 1926 First vaccine for pertussis (whooping cough)
* 1932 First vaccine for yellow fever
* 1937 First vaccine for typhus
* 1941 First vaccine for Tick-borne encephalitis
* 1945 First vaccine for influenza
* 1952 First vaccine for polio (Salk vaccine)
* 1954 First vaccine for Japanese encephalitis
* 1954 First vaccine for anthrax
* 1957 First vaccine for adenovirus-4 and 7
* 1962 First oral polio vaccine (Sabin vaccine)
* 1963 First vaccine for measles
* 1967 First vaccine for mumps
* 1969 First vaccine for cancer
* 1970 First vaccine for rubella
* 1974 First vaccine for chicken pox
* 1977 First vaccine for pneumonia (Streptococcus pneumoniae)
* 1978 First vaccine for meningitis (Neisseria meningitidis)
* 1980 Smallpox declared eradicated worldwide due to vaccination efforts
* 1981 First vaccine for hepatitis B (first vaccine to target a cause of cancer)
* 1985 First vaccine for Haemophilus influenzae type b (HiB)
* 1989 First vaccine for Q fever[3]
* 1991 First vaccine for hepatitis A[4]
* 1998 First vaccine for Lyme disease
* 1998 First vaccine for rotavirus[5]

## 21st century

* 2003 First nasal influenza vaccine approved in U.S. (FluMist)
* 2006 First vaccine for human papillomavirus (which is a cause of cervical cancer)
* 2012 First vaccine for hepatitis E[6]
* 2012 First quadrivalent (4-strain) influenza vaccine
* 2015 First vaccine for enterovirus 71, one cause of hand foot mouth disease[7]
* 2015 First vaccine for malaria[8]
* 2015 First vaccine for dengue fever.[9]
* 2019 First vaccine for ebola.[10]

## See also

* Timeline of global health
* History of smallpox
* Timeline of cholera
* List of diseases eliminated from the United States

## Sources

1. ↑ Vaccine Preventable Deaths and the Global Immunization Vision and Strategy, 2006--2015, MMWR, CDC, 12 May 2006
2. ↑ Historic Dates and Events Related to Vaccines and Immunization, Immunization Action Coalition, immunize.org, December 30, 2016
3. ↑ A Guide to Q fever and Q fever vaccination, CSL Biotherapies, 2009
4. ↑ Patravale, Vandana; Dandekar, Prajakta; Jain, Ratnesh (2012). Nanoparticulate drug delivery perspectives on the transition from laboratory to market (1. publ. ed.). Oxford: Woodhead Pub.. p. 212. ISBN 9781908818195. https://books.google.com/books?id=VWdEAgAAQBAJ&pg=PA212.
5. ↑ Schwartz, Jason L. (2012). "The First Rotavirus Vaccine and the Politics of Acceptable Risk". p. 278-310. doi:10.1111/j.1468-0009.2012.00664.x. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3460207/.
6. ↑ Cao Y, Bing Z, Guan S, Zhang Z, Wang X (2018). "Development of new hepatitis E vaccines.". Human Vaccine & Immunotherapics 14 (9): 2254-2262. doi:10.1080/21645515.2018.1469591. https://www.ncbi.nlm.nih.gov/pubmed/29708836.
7. ↑ Mao, Qun-ying; Wang, Yiping; Bian, Lianlian; Xu, Miao; Liang, Zhenglun (May 2016). "EV71 vaccine, a new tool to control outbreaks of hand, foot and mouth disease (HFMD)". Expert Review of Vaccines 15 (5): 599-606. doi:10.1586/14760584.2016.1138862. https://www.ncbi.nlm.nih.gov/pubmed/26732723/?ncbi_mmode=std. Retrieved 27 December 2019.
8. ↑ Malaria vaccine approval first marred by efficacy question mark, Chemistry World, Maria Burke, 29 July 2015
9. ↑ Sanofi's Dengue Vaccine Dengvaxia Gains Brazilian Approval, Zacks Equity Research, Zacks.com, December 29, 2015
10. ↑ "Merck's Ervebo [Ebola Zaire Vaccine (rVSVΔG-ZEBOV-GP) live] Granted Conditional Approval in the European Union" (Press release). Merck. 11 November 2019. Archived from the original on 11 November 2019. Retrieved 11 November 2019 - via Business Wire.

* keepkidshealthy claims "References: the CDC and Mandell: Principles and Practice of Infectious Diseases, 5th ed.," as its source.

* v
* t
* e

Artificial induction of immunity / Immunization: Vaccines, Vaccination, Infection, Biology:Inoculat, Inoculation (J07)

Development|

* Adjuvants
* List of vaccine ingredients
* Mathematical modelling
* Timeline
* Trials

Classes|

* Conjugate vaccine
* DNA vaccination
* Inactivated vaccine
* Live vector vaccine
* Attenuated vaccine
* Heterologous vaccine
* Subunit/component / Peptide / Virus-like particle
* Toxoid

Administration|

* Global:
* GAVI Alliance
* Policy
* Schedule
* Vaccine injury
* USA:
* ACIP
* Vaccine court
* Vaccines for Children Program
* VAERS
* VSD

Vaccines|

| Bacterial|

* Anthrax
* Brucellosis
* Cholera#
* Diphtheria#
* Hib#
* Leptospirosis
* Lyme disease‡
* Meningococcus#
* MeNZB
* Medicine:NmVac4-A/C/Y/W-135
* Pertussis#
* Plague
* Pneumococcal#
* PCV
* PPSV
* Q fever
* Tetanus#
* Tuberculosis
* BCG#
* Typhoid#
* Ty21a
* ViCPS
* Typhus
* combination: DTwP/DTaP

|

Viral|

* Adenovirus
* Flu#
* H1N1 (Pandemrix)
* LAIV
* Hantavirus
* Hepatitis A#
* Hepatitis B#
* Hepatitis E
* HPV
* Cervarix
* Gardasil
* Japanese encephalitis#
* Measles#
* Mumps#
* Medicine:Mumpsvax
* Polio#
* Sabin
* Salk
* Rabies#
* Rotavirus#
* Rubella#
* Smallpox
* Medicine:Dryvax
* Tick-borne encephalitis
* Varicella zoster
* chicken pox#
* Zoster vaccine
* Yellow fever#
* combination:
* MMR
* MMRV
* research:
* Chikungunya
* Cytomegalovirus
* Dengue
* Ebola
* Epstein–Barr virus
* Hepatitis C
* HIV

Protozoan|

* Malaria
* RTS,S
* research:
* Trypanosomiasis

Helminthiasis|

* research:
* Hookworm
* Schistosomiasis

Other|

* Androvax (androstenedione albumin)
* Cancer vaccines
* ALVAC-CEA
* BCG#
* Hepatitis B#
* HPV
* Cervarix
* Gardasil
* PROSTVAC
* NicVAX
* Ovandrotone albumin (Fecundin)
* TA-CD
* TA-NIC
* combination
* DTaP-IPV/Hib
* DTaP-IPV-HepB
* Hexavalent vaccine
* Pentavalent vaccine

Controversy|

* General
* MMR
* NCVIA
* Pox party
* Thiomersal
* Vaccines and SIDS
* Lancet MMR autism fraud
* Cedillo v. Secretary of Health and Human Services
* Alternative vaccination schedule

Related|

* Epidemiology
* Eradication of infectious diseases
* Every Child by Two
* List of vaccine topics

* #WHO-EM
* ‡Withdrawn from market
* Clinical trials:
* †Phase III
* §Never to phase III

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