All of Us (initiative)

Short description: United States NIH research program

All of Us

Headquarters| Bethesda, Maryland, United States

Parent organization

| National Institutes of Health (NIH)
Website| allofus.nih.gov

The All of Us Research Program (previously known as the Precision Medicine Initiative Cohort Program[1]) is a research program created in 2015 during the tenure of Barack Obama with $130 million[2] in funding that aims to make advances in tailoring medical care to the individual.[3] The mission of All of Us is to accelerate health and medical breakthroughs, enabling individualized prevention, treatment and care.

The project aims to collect genetic and health data from one million volunteers.[4] The initiative was announced during the 2015 State of the Union Address,[5] and is run by the National Institutes of Health (NIH). The program is bilingual, with information and materials available in Spanish and English.

## Contents

* 1 Who can enroll
* 2 Program partners
* 3 Program budget
* 4 Responses to the Initiative
* 5 Program progress
* 5.1 Enrollment
* 5.2 All of Us Researcher Workbench
* 5.3 Response to COVID-19 pandemic
* 5.4 Administration
* 6 See also
* 7 References
* 8 External links

## Who can enroll

Eligible adults (18 and over) can enroll with the program. People who are not eligible are those in prison or people who cannot consent on their own[6] According to a sample consent form released in June 2018, participation in All of Us is voluntary and does not affect a participant's medical care. The form explains that if a participant quits the program, their samples will be destroyed.[7] Children may also be able to enroll in the program.[8]

By January 2018 an initial pilot project had enrolled about 10,000 people and 2022 was targeted for one million people.[9] As of May 2019, enrollment numbers at the one-year launch anniversary are 187,000+ participants. More than 132,000 have already given biosamples.[10]

The NIH reported in May 2018 that they were pleased with the high enrollment by underrepresented groups including communities of color and individuals with lower incomes. Up to three-quarters of beta phase participants came from those communities.[11][8]

## Program partners

All of Us has more than 100 partners and champions working together to implement and support the mission and goals of the research program.[12] Google life sciences startup Verily Life Sciences, a Google "moonshot" with a goal of "transform[ing] the way we detect, prevent, and manage disease"[13][7] is one partner.

The initiative was identified by a 2019 review as involving the public in every stage of the research.[14]

## Program budget

The All of Us Research Program budget has increased every year since it launched: FY2016 - $130 million; FY2017 - $230 million; and FY2018 - $290 million.[15][16]

## Responses to the Initiative

Professor Kenneth Weiss from Pennsylvania State University, in a skeptical review of this project in 2017, suggested that the funding could be better spent elsewhere.[17]

## Program progress

### Enrollment

The research program was launched for national enrollment on May 6, 2018.[11] In the summer of 2019, one year after its official launch, All of Us had enrolled 230,000 participants, which represents almost one quarter of the program's goal of 1,000,000 individuals. Approximately 80% of those people are from groups that have been traditionally underrepresented in biomedical research. One of All of US's main goals is to include many people from diverse ancestries.[18] By June 2020, enrollment reached approximately 350,000 individuals.[19]

### All of Us Researcher Workbench

On May 27, 2020, the All of Us research program announced the launch of their research platform, the All of Us Researcher Workbench, for beta testing. Select data collected by the initiative, including electronic health records and survey responses from the first 225,000 program participants, will be available to approved researchers through the workbench.[19] Researchers may apply for access to the data if they have an NIH eRA Commons account (for identity verification) and are affiliated with an institution that has signed a data use agreement with All of Us.[20]

### Response to COVID-19 pandemic

In June 2020, the NIH announced that research materials collected as part of the All of Us initiative will be used to address the COVID-19 pandemic. Blood samples collected from recent volunteers will be tested for SARS-CoV-2 antibodies in order to track prior infections within the US population.[21] Electronic health records shared by All of Us participants will also be evaluated for potential patterns associated with SARS-CoV-2 infection. All of Us also added monthly participant surveys with questions about the physical, mental, and socioeconomic impacts of the COVID-19 pandemic.[22]

### Administration

The founding program director was Eric Dishman, who stepped down to become the Chief Innovation Officer.[23] In 2019, Joshua Denny was selected to be the second director.[24] In October 2016, the project was renamed "All of Us".[25][26][27]

## See also

* 100,000 Genomes Project (UK)
* 21st Century Cures Act
* Baseline Study
* Precision medicine
* precisionFDA

## References

1. ↑ "FACT SHEET: President Obama's Precision Medicine Initiative". whitehouse.gov. 2015-01-30. https://obamawhitehouse.archives.gov/the-press-office/2015/01/30/fact-sheet-president-obama-s-precision-medicine-initiative.
2. ↑ "About the All of Us Research Program". https://allofus.nih.gov/about/about-all-us-research-program.
3. ↑ "FACT SHEET: President Obama's Precision Medicine Initiative". whitehouse.gov. 30 January 2015. https://obamawhitehouse.archives.gov/the-press-office/2015/01/30/fact-sheet-president-obama-s-precision-medicine-initiative.
4. ↑ Reardon, Sara (1 September 2015). "Giant study poses DNA data-sharing dilemma". Nature. http://www.nature.com/news/giant-study-poses-dna-data-sharing-dilemma-1.18275.
5. ↑ Dvorsky, George (21 January 2015). "How Obama's Precision Medicine Initiative Will Revolutionize Healthcare". io9. http://io9.com/how-obamas-precision-medicine-initiative-will-revolutio-1680866890.
6. ↑ "Who Can Join?". https://www.joinallofus.org/en/who-can-join.
7. ↑ 7.0 7.1 "Verily, Google's bold bid to transform medicine, hits turbulence under a divisive CEO". March 28, 2016. https://www.statnews.com/2016/03/28/google-life-sciences-exodus/.
8. ↑ 8.0 8.1 "How The All of Us Research is Restoring Trust and Bringing A Much-Needed Diversity to Medical Research". 2019-04-10. https://www.radianthealthmag.com/health-wellness/how-the-all-of-us-research-is-restoring-trust-and-bringing-a-much-needed-diversity-to-medical-research/.
9. ↑ Cunningham, Paige Winfield (16 January 2018). "The Health 202: NIH wants 1 million Americans to contribute to new pool of gene data" (in en-US). Washington Post. ISSN 0190-8286. https://www.washingtonpost.com/news/powerpost/paloma/the-health-202/2018/01/16/the-health-202-nih-wants-1-million-americans-to-contribute-to-new-pool-of-gene-data/5a5ba45a30fb0469e8840135/.
10. ↑ "All of Us Research Hub". https://www.researchallofus.org/.
11. ↑ 11.0 11.1 says, Kathleen Flanagan-Olson (May 1, 2018). "NIH opens nationwide enrollment for huge precision medicine initiative". https://www.statnews.com/2018/05/01/nih-precision-medicine-all-of-us-enrollment/.
12. ↑ "All of Us Program Partners". https://allofus.nih.gov/about/program-partners.
13. ↑ Kaiser, Jocelyn (25 February 2016). "NIH's 1-million-volunteer precision medicine study announces first pilot projects". https://www.science.org/content/article/nih-s-1-million-volunteer-precision-medicine-study-announces-first-pilot-projects.
14. ↑ Lacaze, Paul; Fransquet, Peter; Tiller, Jane; Nunn, Jack S. (2019). "Public Involvement in Global Genomics Research: A Scoping Review" (in en). Frontiers in Public Health 7: 79. doi:10.3389/fpubh.2019.00079. ISSN 2296-2565. PMID 31024880.
15. ↑ "All of Us Research Program Backgrounder". https://allofus.nih.gov/news-events-media/media-toolkit/all-us-research-program-backgrounder.
16. ↑ Molteni, Megan (6 May 2018). "The NIH Launches Its Ambitious Million-Person Genetic Survey". Wired. https://www.wired.com/story/all-of-us-launches/.
17. ↑ Weiss, Kenneth M. (Fall 2017). "Is Precision Medicine Possible?" (in en-US). Issues in Science and Technology 34 (1). http://issues.org/34-1/is-precision-medicine-possible/. Retrieved 20 January 2018.
18. ↑ "One Year After Launch, NIH's All of Us Hits Key Milestones". 19 August 2019. https://www.clinicalomics.com/news-and-features/one-year-after-launch-nihs-all-of-us-hits-key-milestones/.
19. ↑ 19.0 19.1 HealthITAnalytics (2020-06-01). ""All of Us" Opens Precision Medicine Data Platform for Beta Testing" (in en-US). https://healthitanalytics.com/news/all-of-us-opens-precision-medicine-data-platform-for-beta-testing.
20. ↑ "All of Us Research Program Begins Beta Testing of Data Platform | National Institutes of Health (NIH) — All of Us". https://allofus.nih.gov/news-events-and-media/announcements/all-us-research-program-begins-beta-testing-data-platform.
21. ↑ "NIH launches COVID-19 tracking initiatives through 'All of Us' precision medicine program". https://www.beckershospitalreview.com/data-analytics/nih-launches-covid-19-tracking-initiatives-through-all-of-us-precision-medicine-program.html.
22. ↑ "NIH Musters Million-Person Study to Track Covid's Spread" (in en). https://news.bloomberglaw.com/health-law-and-business/nih-musters-million-person-study-to-track-covids-spread.
23. ↑ "Statement from Eric Dishman on Changing Leadership at the NIH All of Us Research Program" (in en). 2020-08-21. https://allofus.nih.gov/news-events-and-media/announcements/statement-eric-dishman-changing-leadership-nih-all-us-research-program.
24. ↑ "Selection of Dr. Joshua Denny as Chief Executive Officer of the All of Us Research Program | National Institutes of Health (NIH) — All of Us". https://allofus.nih.gov/news-events-and-media/announcements/selection-dr-joshua-denny-chief-executive-officer-all-us-research-program.
25. ↑ "All of Us (project web page)" (in en). U.S. Department of Health & Human Services - National Institutes of Health. 2018. https://allofus.nih.gov/.
26. ↑ Muoio, Dave (7 November 2017). "Fitbit wearables will help power NIH's All of Us Research Program" (in en). MobiHealthNews. http://www.mobihealthnews.com/content/fitbit-wearables-will-help-power-nihs-all-us-research-program.
27. ↑ "NIH Partners With 14 Community Groups, Healthcare Associations on Outreach for All of Us Program" (in en). GenomeWeb. 17 November 2017. https://www.genomeweb.com/research-funding/nih-partners-14-community-groups-healthcare-associations-outreach-all-us-program.

## External links

* Join All of Us homepage to join the All of Us research program
* All of Us homepage at the National Institutes of Health
* NIH Innovation account on USAspending.gov

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