Center for Cell and Gene Therapy

The Center for Cell and Gene Therapy is a translational research institute within Baylor College of Medicine, Texas Children's Hospital[1] and Houston Methodist Hospital,[2] all of which are located in the Texas Medical Center in Houston, Texas. The center's mission is to develop novel therapies for a range of diseases through collaboration between basic research laboratories and clinical departments.[3] The center was founded by Dr. Malcolm K. Brenner in 1998 and includes six major parts.[4] The current director is Dr. Helen E. Heslop, physician-scientist who specializes in translational research.

The Center for Cell and Gene Therapy conducts research into numerous diseases, including but not limited to pediatric cancers,[5][6] diabetes,[7] HIV, glioma[8] and cardiovascular disease. The center has laboratory space in both Baylor College of Medicine and Texas Children's Hospital, and clinical units in Texas Children's and Methodist Hospitals.[9]

The Texas Children's Hospital is home to the center's Translational Research Labs and Good Manufacturing Practice (GMP) Laboratories. The Center for Cell and Gene Therapy has the largest academic GMP facility in the world, with 8,600 square feet of Class 10,000 (ISO7) cleanroom space. The GMP Gene Vector Lab produces clinical grade vectors for use in Phase I/II trials, while the GMP Clinical Research Lab prepares patient components for clinical trials. The Gene Vector Lab was one of only three National Gene Vector Laboratories until that entity was replaced by the National Gene Vector Biorepository in 2008. The Research Lab is a member of the Production Assistance for Cell Therapies (PACT).[10]

The Stem Cell Transplantation Program has two units. The pediatric unit has more than 16,000 square feet on the eighth floor of Texas Children's Hospital's West Tower. The 30,000-square foot adult unit is in The Methodist Hospital's Main Tower.

## References

1. ↑ Texas Children's Hospital "Texas Children's Cancer and Hematology Centers Center for Cell and Gene Therapy (CAGT) | Texas Children's Cancer Center". Archived from the original on 2013-09-19. https://web.archive.org/web/20130919081850/http://txch.org/research/center-for-cell-and-gene-therapy/. Retrieved 2009-08-11. "Center for Cell and Gene Therapy" July 10, 2014
2. ↑ Houston Methodist Hospital [1] "Center for Cell and Gene Therapy" July 10, 2014
3. ↑ Baylor College of Medicine [2][yes|permanent dead link|dead link}}] Center for Cell and Gene Therapy July 10, 2014
4. ↑ Dr. Malcolm K. Brenner [3][yes|permanent dead link|dead link}}] Baylor College of Medicine
5. ↑ Houston Chronicle [4] "New Immunotherapy Kills Post Transplant Viruses" June 25, 2014
6. ↑ BioNews Texas [5] "BCM Immunotherapy Research Granted" June 13, 2014
7. ↑ Chen, Shuibing; Borowiak, Malgorzata; Fox, Julia L.; Maehr, René; Osafune, Kenji; Davidow, Lance; Lam, Kelvin; Peng, Lee F. et al. (April 2009). "A small molecule that directs differentiation of human ESCs into the pancreatic lineage". Nature Chemical Biology 5 (4): 258–265. doi:10.1038/nchembio.154. PMID 19287398.
8. ↑ Deneen, Benjamin; Ho, Ritchie; Lukaszewicz, Agnes; Hochstim, Christian J.; Gronostajski, Richard M.; Anderson, David J. (21 December 2006). "The Transcription Factor NFIA Controls the Onset of Gliogenesis in the Developing Spinal Cord". Neuron 52 (6): 953–968. doi:10.1016/j.neuron.2006.11.019. PMID 17178400.
9. ↑ Neergaard, Lauran (25 June 2014). "Designer T cells fight viruses after transplants". Medical Xpress. The Associated Press. https://medicalxpress.com/news/2014-06-cells-viruses-transplants.html.
10. ↑ "Home". http://www.pactgroup.net/.

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