PANACREAS

Integrating chemical approaches to treat pancreatic cancer: making new leads for a cure

Funding
European Commission Seventh Framework Programme
Project
Collaborative project
Grant agreement N°
256986
Starting date
March1st, 2011
Duration
5 years
Website
http://www.panacreas.eu[1]
Participants
UKB| Universitaetsklinikum Bonn[2] (coordinator) (GERMANY)
UNIGE| Università degli Studi di Genova[3](ITALY)
CSIC| Agencia Estatal Consejo Superior de Investigaciones Cientificas[4] (SPAIN)
EPFL| École Polytechnique Fédérale de Lausanne[5] (SWITZERLAND)
CHUV| University Hospital of Lausanne[6] (SWITZERLAND)
USE| Universidad de Sevilla[7] (SPAIN)
UNITN| Università degli Studi di Trento[8] (ITALY)
SIB| Swiss Institute of Bioinformatics[9] (SWITZERLAND)
ULUND| Lunds Universitet[10] (SWEDEN)
DEBIO| Debiopharm SA[11] (SWITZERLAND)
Apointech| Apointech S.L.[12] (SPAIN)
ALTA| ALTA S.r.l.u.[13] (ITALY)

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PANACREAS stands for “Integrating chemical approaches to treat pancreatic cancer: making new leads for a cure” and is being supported through Coordination Theme 1 (Health) of the European Community’s FP7.

## Contents

* 1 Summary
* 2 Expected results
* 3 Notes and references

## Summary

Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human malignancies and a major health problem. It has been estimated that PDAC causes 34000 deaths per year in the EU alone.[14] Despite considerable research efforts in the past decades, conventional treatment approaches, including surgery, radiation, chemotherapy, and combinations of these, have close to no impact on the course of this aggressive neoplasm. Therefore, virtually all of the patients diagnosed with PC develop metastases and die[15] Given this scenario, the search for new drugs to combat PDAC progression and thus increase patient life expectancy and quality of life has been given high priority.[16] In particular, the National Cancer Institute’s Gastrointestinal Cancer Steering Committee has recently place major emphasis on the enhancement of "research to identify and validate the relevant targets and molecular pathways in PDAC, cancer stem cells, and the microenvironment";

## Expected results

The work proposed in this program meets the need to reverse-translate the clinical issues encountered in PDAC into tailored researches to overcome such problems. Particularly, resistance to conventional therapeutics and high propensity to metastasize were taken into account when choosing for this project therapeutics that act through novel modes of action, and molecular targets that are emerging as crucially involved in metastasis. Our consortium will produce numerous new molecules to be tested and validated for their anticancer activity. This represents the conditio sine qua non for the finding of drugs that can be effective against PDAC. The most promising compounds will be evaluated in clinically relevant mouse models of PDAC. Finally strong proof-of-concept activity of any of these compounds will be a green light for proceeding to an Investigational New Drug-(IND)-enabling study. In the time frame of this project, we will aim to release one or more molecules that are ready to be tested in clinical studies. The ultimate goal of these efforts will be to arrest PDAC progression and reduce mortality.

## Notes and references

1. ↑ [1] [|permanent dead link|dead link}}]
2. ↑ "UKB Startseite". https://www.ukbonn.de/.
3. ↑ "UniGe.it". https://unige.it/it/https:/unige.it/it.
4. ↑ "Consejo Superior de Investigaciones Científicas - CSIC - csic.es". https://www.csic.es/es.
5. ↑ "Home". https://www.epfl.ch/en/.
6. ↑ "Accueil". https://www.chuv.ch/fr/chuv-home?feed=atom&cHash=111b131caa83f7236554a7be1e3f085c.
7. ↑ "| Portal Universidad de Sevilla". https://www.us.es/.
8. ↑ "UniTrento". https://www.unitn.it/it.
9. ↑ "Home page". https://www.sib.swiss/.
10. ↑ "Start". https://www.lu.se/start.
11. ↑ "Debiopharm". https://www.debiopharm.com/.
12. ↑ [2] [|permanent dead link|dead link}}]
13. ↑ "ALTA". https://www.altaweb.eu/.
14. ↑ Ferlay J (2007). "Estimates of the cancer incidence and mortality in Europe in 2006". Ann Oncol 18 (3): 581–592. doi:10.1093/annonc/mdl498. PMID 17287242.
15. ↑ Li D (2004). "Pancreatic cancer". Lancet 363 (9414): 1049–1057. doi:10.1016/S0140-6736(04)15841-8. PMID 15051286.
16. ↑ Philip PA (Nov 2009). "Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment". J Clin Oncol 27 (20): 5660–5669. doi:10.1200/JCO.2009.21.9022. PMID 19858397.

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