Controversies in autism

Short description: Controversies about both the cause of autism and the nature of the diagnoses themselves

Diagnoses of autism have become more frequent since the 1980s, which has led to various controversies about both the cause of autism and the nature of the diagnoses themselves. Whether autism has mainly a genetic or developmental cause, and the degree of coincidence between autism and intellectual disability, are all matters of current scientific controversy as well as inquiry. There is also more sociopolitical debate as to whether autism should be considered a disability on its own.[1]

## Contents

* 1 Epidemiology
* 2 Genetics
* 3 Bacteria
* 4 Vaccines
* 5 Intelligence
* 6 Facilitated communication
* 7 Advocacy initiatives
* 7.1 Pathology paradigm
* 7.2 Neurodiversity paradigm
* 8 Further reading
* 9 See also
* 10 References

## Epidemiology

Main article: Medicine:Epidemiology of autism

The current accepted prevalence of autism spectrum disorder (ASD) are around 1%,[2] although previous research has shown far lower rates of incidence.[3] ASD averages a 4.3:1 male-to-female ratio. The number of children on the autism spectrum has increased dramatically since the 1980s, at least partly due to changes in diagnostic practice; it is unclear whether prevalence has actually increased;[4] and as-yet-unidentified environmental risk factors cannot be ruled out.[5] The risk of autism is associated with several prenatal factors, including advanced parental age and diabetes in the mother during pregnancy.[6] ASD is associated with several genetic disorders[7] and epilepsy.[8]

## Genetics

Further information: Medicine:Heritability of autism

The role of genetic influence on ASD has been heavily researched over the past few years. ASD is considered to have polygenic traits since there is not a single risk factor, but multiple ones.[9]

Multiple twin and family studies have been conducted in order to observe any genetic influence in diagnosing ASD. The chance of both twins having ASD was significantly higher in identical twins than fraternal twins, concluding that ASD is heritable.[10] A reoccurring finding is that de novo (new mutation) copy number variants (CNVs) are a primary cause of ASD – they alter synaptic functions; germ line mutations can produce de novo CNVs.[11] These mutations can only be passed on to offspring; this explains the phenomenon that occurs when the child has symptoms of ASD, but the parents have no symptoms or history of ASD. De novo variants differ from person to person, i.e. one variant can cause ASD in one person, whereas another person would need multiple variants to cause the same disorder.[10] Loss of function variants occur in 16-18% of ASD diagnoses, which is nearly double the normal population.[9] These loss of function variants reduce function in the protein neurexin, which connects neurons at the synapse and is important for neurological development; deletion mutations of neurexin are also very common in people with autism, as well as other neurological disorders like schizophrenia, bipolar disorder, and ADHD.[12]

There is also controversy over the Nature vs. Nurture debate. According to family studies, genetic and environmental factors have an equal influence on risk of ASD.[10]

## Bacteria

Gut microbiome has a relation to ASD. Excessive Clostridia spp. was found in children with ASD and gastrointestinal difficulties; Clostridia spp produces propionic acid, which is impaired or in excess in people with ASD.[13] Specifically, C. tetani and C. histolyticum are two species of this bacteria that affect people with ASD. C. tetani produces tetanus neurotoxin in the intestinal tract; C. histolyticum is a toxin producer that is abundant in people diagnosed with ASD.[14] Both of these could contribute to neurological symptoms.

## Vaccines

Main article: Unsolved:Vaccines and autism

A later-retracted article from The Lancet making false claims provoked concern about vaccines among parents. Its author was found to be on the payroll of litigants against vaccine manufacturers.[15]

The idea of a link between vaccines and autism was extensively investigated and shown to be false.[16] The scientific consensus is that there is no relationship, causal or otherwise, between vaccines and incidence of autism,[17][18][16] and vaccine ingredients do not cause autism.[19]

Nevertheless, the anti-vaccination movement continues to promote myths, conspiracy theories and misinformation linking the two.[20] A developing tactic appears to be the "promotion of irrelevant research [as] an active aggregation of several questionable or peripherally related research studies in an attempt to justify the science underlying a questionable claim."[21]

## Intelligence

The percentage of autistic individuals who also meet criteria for intellectual disability has been reported as anywhere from 25% to 70%, a wide variation illustrating the difficulty of assessing autistic intelligence.[22] For pervasive developmental disorder not otherwise specified (PDD-NOS), the association with intellectual disability is much weaker.[23] The diagnosis of Asperger syndrome excludes clinically significant delays in mental or cognitive skills.[24]

A 2007 study suggested that Raven's Progressive Matrices (RPM), a test of abstract reasoning, may be a better indicator of intelligence for autistic children than the more commonly used Wechsler Intelligence Scale for Children (WISC). Researchers suspected that the WISC relied too heavily on language to be an accurate measure of intelligence for autistic individuals. Their study revealed that the neurotypical children scored similarly on both tests, but the autistic children fared far better on the RPM than on the WISC. The RPM measures abstract, general and fluid reasoning, an ability autistic individuals have been presumed to lack.[25] A 2008 study found a similar effect, but to a much lesser degree and only for individuals with IQs less than 85 on the Wechsler scales.[26]

## Facilitated communication

Further information: Social:Facilitated communication

Facilitated communication (FC) is a scientifically discredited technique[27] that attempts to facilitate communication by people with severe educational and communication disabilities. The facilitator holds or gently touches the disabled person's arm or hand during this process and attempts to help them move to type on a special keyboard. It was used by many hopeful parents of individuals with autism when it was first introduced during the early 1990s by Douglas Biklen, a professor at Syracuse University.[28]

There is widespread agreement within the scientific community and multiple disability advocacy organizations that FC is not a valid technique for authentically augmenting the communication skills of those with autism spectrum disorder.[29] Instead, research indicates that the facilitator is the source of the messages obtained through FC (involving ideomotor effect guidance of the arm of the patient by the facilitator).[30][31] Thus, studies have consistently found that patients are unable to provide the correct response to even simple questions when the facilitator does not know the answers to the questions (e.g., showing the patient but not the facilitator an object).[32] In addition, numerous cases have been reported by investigators in which disabled persons were assumed by facilitators to be typing a coherent message while the patient's eyes were closed or while they were looking away from or showing no particular interest in the letter board.[33] Despite the evidence opposing FC, many continue to use and promote this technique.[29]

Note that facilitated communication is separate and different from a range of scientifically supported augmentative and alternative communication (AAC) devices and processes that facilitate communication for people with communication difficulties.

## Advocacy initiatives

There are two major conceptualizations of autism within autism advocacy. Those who favour the pathology paradigm, which aligns with the medical model of disability, see autism as a disorder to be treated or cured. Those who favor the pathology paradigm argue that atypical behaviors of autistic individuals are detrimental and should therefore be reduced or eliminated through behavior modification therapies. Their advocacy efforts focus primarily on medical research to identify genetic and environmental risk factors in autism. Those who favour the neurodiversity paradigm, which aligns with the social model of disability, see autism as a naturally-occurring variation in the brain. Neurodiversity advocates argue that efforts to eliminate autism should not be compared, for example, to curing cancer, but instead to the antiquated notion of curing left-handedness. Their advocacy efforts focus primarily on acceptance, accommodation, and support for autistic people as "neuro-minorities" in society.[34] These two paradigms are not fully exclusive, and many people hold a combination of these viewpoints.[citation needed]

### Pathology paradigm

The pathology paradigm is the traditional view of autism through a biomedical lens, in which it is seen as a disorder characterized by various impairments, mainly in communication and social interaction.[35][36] Those taking this perspective believe that autism is generally a harmful dysfunction.[34] Ways of functioning which diverge from a typical brain are perceived as harmful and disordered and must therefore be treated or cured.[37] The atypical behaviors of autistic individuals are considered a detriment to social and professional success and should therefore be reduced or eliminated through therapy.[38][39]

Advocates with this view include both a small but significant minority of autistic adults and large majority of parents of autistic children, but contain a higher percentage of parents when compared to those adopting the neurodiversity paradigm.[40][citation needed] These advocates believe that medical research is necessary to address the rapid rise in autism diagnoses (sometimes referred to as the "autism epidemic"),[40] reduce suffering, and provide the best outcomes for autistic individuals. In addition to etiological research, other areas of focus may include biology, diagnosis, and treatment, including medication, behavioural and psychological interventions, and the treatment of co-existing medical conditions.[41]

Advocacy groups that focus primarily on medical research include Autism Speaks, the Autism Science Foundation, and its predecessor organizations, the Autism Coalition for Research and Education, the National Alliance for Autism Research, and Cure Autism Now, and the former Autism Research Institute.

### Neurodiversity paradigm

The neurodiversity paradigm is a view of autism as a different way of being rather than as a disease or disorder that must be cured.[40][42] Autistic people are considered to have neurocognitive differences[34] which give them distinct strengths and weaknesses, and are capable of succeeding when appropriately accommodated and supported.[40][42] The belief is that efforts to eliminate autism should not be compared, for example, to curing cancer but instead to the antiquated notion of curing left-handedness.[43]

There is no leader of the neurodiversity movement and little academic research has been conducted on it as a social phenomenon.[34] As such, proponents of the neurodiversity paradigm have heterogenous beliefs,[34] but are consistent in the view that autism cannot be separated from an autistic person.[40] Advocacy efforts may include accommodations in schools and work environments,[44] lobbying for the inclusion of autistic people when making decisions that affect them,[45] and opposition to therapies that aim to make children "indistinguishable from their peers".[40]

Neurodiversity advocates are opposed to medical research for a cure, believing that it will lead to eugenics, and instead support research that helps autistic people thrive as they are.[40] For example, NeuroTribes author Steve Silberman noted a lack of research in regards to seizure-controlling drugs and autistic brains; that sensory differences in autistic people were unheard of until Temple Grandin spoke about her experiences; and that only a small percentage of research funding goes towards the needs of autistic adults.[42][44][46]

Advocacy groups that focus primarily on acceptance and accommodation include Autism Network International, Autism National Committee, Autistic Self Advocacy Network, and Autistic Women & Nonbinary Network.

## Further reading

* Decoteau, C. L., & Daniel, M. (2020). Scientific Hegemony and the Field of Autism. American Sociological Review.

## See also

* Neurodiversity

## References

1. ↑ Morgan, Jules (2016-10-01). "Autism spectrum disorder: difference or disability?" (in en). The Lancet Neurology 15 (11): 1126. doi:10.1016/S1474-4422(16)30002-3. ISSN 1474-4422. https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(16)30002-3/abstract.
2. ↑ Lai, Meng-Chuan; Lombardo, Michael V; Baron-Cohen, Simon (March 2014). "Autism" (in en). The Lancet 383 (9920): 896–910. doi:10.1016/S0140-6736(13)61539-1. PMID 24074734. https://linkinghub.elsevier.com/retrieve/pii/S0140673613615391.
3. ↑ Newschaffer, Craig J.; Croen, Lisa A.; Daniels, Julie; Giarelli, Ellen; Grether, Judith K.; Levy, Susan E.; Mandell, David S.; Miller, Lisa A. et al. (2007-04-01). "The Epidemiology of Autism Spectrum Disorders" (in en). Annual Review of Public Health 28 (1): 235–258. doi:10.1146/annurev.publhealth.28.021406.144007. ISSN 0163-7525. PMID 17367287.
4. ↑ "The epidemiology of autism spectrum disorders". Annual Review of Public Health 28: 235–58. 2007. doi:10.1146/annurev.publhealth.28.021406.144007. PMID 17367287.
5. ↑ "Incidence of autism spectrum disorders: changes over time and their meaning". Acta Paediatrica 94 (1): 2–15. January 2005. doi:10.1111/j.1651-2227.2005.tb01779.x. PMID 15858952.
6. ↑ "Prenatal risk factors for autism: comprehensive meta-analysis". The British Journal of Psychiatry 195 (1): 7–14. July 2009. doi:10.1192/bjp.bp.108.051672. PMID 19567888.
7. ↑ "Childhood autism and associated comorbidities". Brain & Development 29 (5): 257–72. June 2007. doi:10.1016/j.braindev.2006.09.003. PMID 17084999.
8. ↑ "The autism-epilepsy connection". Epilepsia 48 (Suppl 9): 33–5. 2007. doi:10.1111/j.1528-1167.2007.01399.x. PMID 18047599.
9. ↑ 9.0 9.1 "Genetic research in autism spectrum disorders". Current Opinion in Pediatrics 27 (6): 685–91. December 2015. doi:10.1097/MOP.0000000000000278. PMID 26371945.
10. ↑ 10.0 10.1 10.2 "Current knowledge on the genetics of autism and propositions for future research". Comptes Rendus Biologies 339 (7–8): 300–7. 2016-07-01. doi:10.1016/j.crvi.2016.05.004. PMID 27289453.
11. ↑ "The role of de novo mutations in the genetics of autism spectrum disorders" (in En). Nature Reviews. Genetics 15 (2): 133–41. February 2014. doi:10.1038/nrg3585. PMID 24430941.
12. ↑ "Synaptic proteins and receptors defects in autism spectrum disorders". Frontiers in Cellular Neuroscience 8: 276. 2014-09-11. doi:10.3389/fncel.2014.00276. PMID 25309321.
13. ↑ "Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome". Microbial Ecology in Health and Disease 26: 27458. 2015-05-07. doi:10.3402/mehd.v26.27458. PMID 25956238.
14. ↑ "The Gut Microbiota and Autism Spectrum Disorders". Frontiers in Cellular Neuroscience 11: 120. 2017. doi:10.3389/fncel.2017.00120. PMID 28503135.
15. ↑ ((The Editors of The Lancet)) (February 2010). "Retraction--Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children". Lancet 375 (9713): 445. doi:10.1016/S0140-6736(10)60175-4. PMID 20137807.
* "Lancet accepts MMR study 'false'". BBC News. 2010-02-02. http://news.bbc.co.uk/2/low/health/8493753.stm.
16. ↑ 16.0 16.1 Taylor, Luke E.; Swerdfeger, Amy L.; Eslick, Guy D. (2014-06-17). "Vaccines are not associated with autism: an evidence-based meta-analysis of case-control and cohort studies". Vaccine 32 (29): 3623–3629. doi:10.1016/j.vaccine.2014.04.085. ISSN 1873-2518. PMID 24814559.
17. ↑ "Adverse events following immunization: perception and evidence". Current Opinion in Infectious Diseases 20 (3): 237–46. June 2007. doi:10.1097/QCO.0b013e32811ebfb0. PMID 17471032. http://lib.ajaums.ac.ir/booklist/955899.pdf. Retrieved 2019-02-07.
18. ↑ Boseley, Sarah (February 2, 2010). "Lancet retracts 'utterly false' MMR paper". The Guardian. https://www.theguardian.com/society/2010/feb/02/lancet-retracts-mmr-paper.
19. ↑ "Vaccines Do Not Cause Autism Concerns" (in en-us). 2018-12-12. https://www.cdc.gov/vaccinesafety/concerns/autism.html.
20. ↑ Cummins, Eleanor (February 1, 2019). "How autism myths came to fuel anti-vaccination movements" (in en). Popular Science. https://www.popsci.com/timeline-autism-myth-anti-vaccine.
21. ↑ Foster, Craig A.; Ortiz, Sarenna M. (2017). "Vaccines, Autism, and the Promotion of Irrelevant Research: A Science-Pseudoscience Analysis". Skeptical Inquirer 41 (3): 44–48. https://www.csicop.org/si/show/vaccines_autism_and_the_promotion_of_irrelevant_research_a_science-pseudosc. Retrieved 6 October 2018.
22. ↑ Byrne JH (-in-chief), Roediger HL III (vol.), ed (2008). "Learning in autism". Learning and Memory: A Comprehensive Reference. 2. Academic Press. pp. 759–72. doi:10.1016/B978-012370509-9.00152-2. ISBN 978-0-12-370504-4. http://psych.wisc.edu/lang/pdf/Dawson_AutisticLearning.pdf. Retrieved 2009-09-07.
23. ↑ "Pervasive developmental disorders in preschool children". JAMA 285 (24): 3093–9. June 2001. doi:10.1001/jama.285.24.3093. PMID 11427137.
24. ↑ DSM-IV-TR Diagnostical and Statistical Manual of Mental Disorders Fourth edition text revision. American Psychiatric Association, Washington DC. 2000. pp. 80.
25. ↑ "The level and nature of autistic intelligence". Psychological Science 18 (8): 657–62. August 2007. doi:10.1111/j.1467-9280.2007.01954.x. PMID 17680932.
* "The Matrix Of Autism". ScienceDaily (Press release). 2007-08-05.
26. ↑ "Brief report: The level and nature of autistic intelligence revisited". Journal of Autism and Developmental Disorders 39 (4): 678–82. April 2009. doi:10.1007/s10803-008-0667-2. PMID 19052857.
27. ↑ Vyse, Stuart (7 August 2018). "Autism Wars: Science Strikes Back". Skeptical Inquirer. https://www.csicop.org/specialarticles/show/autism_wars_science_strikes_back.
28. ↑ "Institute on Communication and Inclusion". http://soe.syr.edu/centers_institutes/institute_communication_inclusion/default.aspx.
29. ↑ 29.0 29.1 Hemsley, Bronwyn; Bryant, Lucy; Schlosser, Ralf; Shane, Howard; Lang, Russell; Paul, Diane; Benajee, Meher; Ireland, Marie (2018). "Systematic review of facilitated communication 2014-2018 finds no new evidence that messages delivered using facilitated communication are authored by the person with the disability". Autism and Developmental Language Impairments 3: 1–8. doi:10.1177/2396941518821570.
30. ↑ Lilienfeld. "Why debunked autism treatment fads persist". Emory University. https://www.sciencedaily.com/releases/2015/02/150226154644.htm.
31. ↑ Ganz, Jennifer B.; Katsiyannis, Antonis; Morin, Kristi L. (February 2017). "Facilitated Communication". Intervention in School and Clinic 54: 52–56. doi:10.1177/1053451217692564.
32. ↑ Montee, B B; Miltenberger, R G; Wittrock, D; Watkins, N; Rheinberger, A; Stackhaus, J (1995). "An experimental analysis of facilitated communication.". Journal of Applied Behavior Analysis 28 (2): 189–200. doi:10.1901/jaba.1995.28-189. PMID 7601804.
33. ↑ Goldacre, Ben (2009-12-05). "Making contact with a helping hand". The Guardian. https://www.theguardian.com/commentisfree/2009/dec/05/bad-science-ben-goldacre-column.
34. ↑ 34.0 34.1 34.2 34.3 34.4 Chapman, Robert (2019). "Neurodiversity Theory and Its Discontents: Autism, Schizophrenia, and the Social Model of Disability". in Tekin, Serife. The Bloomsbury Companion to Philosophy of Psychiatry. Bloomsbury Academic. pp. 371–387. ISBN 9781350024069. https://books.google.com/books?id=PV95DwAAQBAJ&pg=PA371.
35. ↑ Liu, Ka-Yuet; King, Marissa; Bearman, Peter S. (March 2010). "Social influence and the autism epidemic". American Journal of Sociology 115 (5): 1387–1434. doi:10.1086/651448. ISSN 0002-9602. PMID 20503647.
36. ↑ "What is Autism?" (in en-US). https://autismsciencefoundation.org/what-is-autism/.
37. ↑ Feinstein, Adam (2017-12-11). "Neurodiversity: the cases for and against" (Notes for presentation). http://blogs.exeter.ac.uk/exploringdiagnosis/files/2017/03/Adam-Feinstein-notes-for-neurodiversity-talk-for-Exeter-December-11-2017.pdf.
38. ↑ "Autism Speaks releases new strategic plan for science" (in en). https://www.autismspeaks.org/science-news/autism-speaks-releases-new-strategic-plan-science.
39. ↑ "Strategic Plan for Science 2018-2020". 2017-12-13. https://www.autismspeaks.org/sites/default/files/2018-09/autism-speaks-strategic-plan-science-2018-2012.pdf.
40. ↑ 40.0 40.1 40.2 40.3 40.4 40.5 40.6 Solomon, Andrew (2008-05-23). "The Autism Rights Movement" (in en). http://nymag.com/news/features/47225/.
41. ↑ Twachtman-Cullen D (2008). "Dr. Geraldine Dawson: setting the research agenda for Autism Speaks". Autism Spectr Q (16): 8–11. http://asquarterly.com/articles/dawson_interview.pdf.
42. ↑ 42.0 42.1 42.2 Silberman, Steve (2016-04-04). "Autistic people are not failed versions of "normal." They're different, not less" (in en). https://ideas.ted.com/autistic-people-are-not-failed-versions-of-normal-theyre-different-not-less/.
43. ↑ Harmon, Amy (2004-12-20). "How About Not 'Curing' Us, Some Autistics Are Pleading" (in en-US). The New York Times. ISSN 0362-4331. https://www.nytimes.com/2004/12/20/health/how-about-not-curing-us-some-autistics-are-pleading.html.
44. ↑ 44.0 44.1 Nerenberg, Jenara (2016-11-21). "Does Neurodiversity Have a Future?" (in en). https://greatergood.berkeley.edu/article/item/does_neurodiversity_have_a_future.
45. ↑ "Position Statements" (in en). https://autisticadvocacy.org/about-asan/position-statements/.
46. ↑ Teitel, Emma (2015-08-25). "Steve Silberman on autism and 'neurodiversity'". Toronto: Rogers Media. https://www.macleans.ca/society/science/steve-silberman-on-autism-and-the-neurodiversity-movement/.

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Pervasive developmental disorders and autism spectrum (F84, 299)

Main|

* Causes
* Comorbid conditions
* Epidemiology
* Heritability
* Societal and cultural aspects
* Medical model
* Therapies

Diagnoses|

* Autism spectrum (High-functioning autism
* Classic Autism
* Asperger syndrome
* Pervasive developmental disorder not otherwise specified
* Childhood disintegrative disorder
* Rett syndrome)

Related conditions|

* Alexithymia
* Attention deficit hyperactivity disorder
* Anxiety disorder (obsessive–compulsive disorder)
* Late talker
* Epilepsy
* Fragile X syndrome
* Hyperlexia
* Savant syndrome
* Sensory processing disorder
* Intellectual disability
* Developmental coordination disorder
* Multiple complex developmental disorder

Controversies|

* Autism rights movement
* Autistic enterocolitis
* Facilitated communication
* MMR vaccine
* Rapid prompting method
* Thiomersal (Chelation)

Diagnostic scales|

* Gilliam Asperger's disorder scale
* Autism Diagnostic Observation Schedule
* Autism Diagnostic Interview
* Autism-spectrum quotient
* Childhood Autism Rating Scale

Lists|

* Autism-related topics
* Fictional characters
* Schools

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