Cyclopia

Cyclopia (named after the Greek mythology characters cyclopes), also known as alobar holoprosencephaly, is the most extreme form of holoprosencephaly and is a congenital disorder (birth defect) characterized by the failure of the embryonic prosencephalon to properly divide the orbits of the eye into two cavities. Its incidence is 1 in 16,000 in born animals and 1 in 200 in miscarried fetuses.[1][2]

## Contents

* 1 Signs and symptoms
* 2 Causes
* 3 Notable cases
* 4 Cultural significance
* 5 Gallery
* 5.1 Humans
* 5.2 Animals
* 6 See also
* 7 References
* 8 External links

## Signs and symptoms

Typically, the nose is either missing or not functional. This deformity (called proboscis) forms above the center eye and is characteristic of a form of cyclopia called rhinencephaly or rhinocephaly.[3] Most such embryos are either naturally miscarried or are stillborn upon delivery.[citation needed]

Although cyclopia is rare, several cyclopic human babies are preserved in medical museums (e.g. The Vrolik Museum, Amsterdam, Trivandrum Medical College).[4]

Some extreme cases of cyclopia have been documented in farm animals (horses, sheep, pigs, goats, and sometimes chickens). In such cases, the nose and mouth fail to form, or the nose grows from the roof of the mouth, obstructing airflow and resulting in suffocation shortly after birth.[5]

## Causes

Genetic defects or toxins can misdirect the embryonic forebrain-dividing process.[6] One highly teratogenic alkaloid toxin that can cause cyclopia is cyclopamine or 2-deoxyjervine, found in the plant Veratrum californicum (also known as corn lily or false hellebore). Grazing animals are most likely to ingest this plant and induce cyclopia in offspring. People sometimes accidentally ingest false hellebore while pregnant thinking it is hellebore, which has been suggested as a "natural" treatment for vomiting, cramps, and poor circulation – three conditions which may be present in the early stages of pregnancy.[7] Cyclopia occurs when certain proteins are inappropriately expressed,[8] causing the brain to stay whole, rather than developing two distinct hemispheres. This leads to the fetus having one optic lobe and one olfactory lobe, resulting in the eye and nose malformations of cyclopia.[9]

The Sonic hedgehog protein (SHH) is the gene regulator involved in the separation of the single eye field into two bilateral fields.[10] Although not proven, it is thought that SHH emitted from the prechordal plate suppresses Pax6, which causes the eye field to divide into two. If the SHH gene is mutated, the result is cyclopia, a single eye in the center of the face (Gilbert, 2000).

## Notable cases

* A British description from 1665 of a colt that appeared to have cyclopia reads:

> First, That it had no sign of any Nose in the usual place, nor had it any, in any other place of the Head, unless the double Bagg CC that grew out of the midst of the forehead, were some rudiment of it. Next, That the two Eyes were united into one Double Eye which was placed just in the middle of the Brow.[11]

* In October 1766, an infant in France was born with cyclopia, living for only a few hours. Reports of the case were made in the Mercure de France and an illustration of the infant was made by Marie Bihéron. The case was also mentioned in Volume IV of Buffon's L'Histoire Naturelle.

A Swedish description from 1793 of a newborn with cyclopia

* On 1 March 1793, a 46-year-old woman in Boalts Torp, Glimåkra, Sweden gave birth to a child with cyclopia that died after two hours. The child was 35 cm long, its face without nose and nostrils, and its lidless eye with no eyebrow sat raised on the middle of its forehead like a large blueberry. The wrists were somewhat crooked as well as the right foot which was completely crooked and bent inwards. It was not clear whether it was a boy or a girl, but it was believed to be the former.[12]
* In November 1889, reports emerged from Umatilla County, Oregon, of a Nez Perce child with one eye in the center of the forehead. The child was reportedly healthy and "able to see with ease, and ran about with as much freedom as any of his companions."[13][14][15] Several individuals tried to locate the child to be put on display, but the tribe had left to hunt in the mountains by the time they arrived.[16] It is unknown what became of the child.
* On December 28, 2005, a kitten with cyclopia, "Cy", was born in Redmond, Oregon, United States and died about one day after birth.[17]
* In 2006, a baby girl with cyclopia was born in Chennai, India. Her only eye was in the center of her forehead. She did not have a nose and her brain did not separate into two separate hemispheres (holoprosencephaly).[18] She died approximately a month after her birth, surviving longer than any known previous case.[19]
* A boy with one eye and no nose was born in India in 2011. The child died one day after his birth.[20]
* In 2011, an albino cyclops shark fetus was discovered in the body of a caught shark in Mexico, with no discernible nose and one giant eye. The unborn fetus was turned over for medical studies.[21]
* On October 10, 2012, a small kitten was born. Its eye was in the center of the forehead and there was no developed nose to be found. The small cat died shortly after it was born. It was nicknamed Cleyed the Cyclops.[22]
* On May 10, 2017, in Assam, India, a black goat was born with one eye and other cyclopia-related facial abnormalities. It was reported to still be alive over a week later, which is unusual for this condition.[23]
* On September 13, 2018, in Mandailing Natal, North Sumatra, Indonesia, a baby with cyclopia was born without a nose and one eye with the weight of 2.4kg (5.3lb) and heart rate under 100 bpm. The child died seven hours after birth.[24]
* On March 16, 2022, a boy was born in Al Bayda, Yemen, with cyclopia. He died 7 hours after birth. He was seen in photos taken by Yemeni journalist Karim Zarai.[25]
* In March 2024, a pig was born in Ilocos Sur, Philippines, with cyclopia.[26]
* In December 2024, the Korean Society of Perinatology documented a female infant with cyclopia who survived for 8 months on palliative care, which is the longest known to date. The baby girl was born as part of a twin birth, with the other twin being reportedly normal.[27]
* In November 2025, a kitten with cyclopia was born on a farm in Vilhena (located within the western state of Rondônia in Brazil).[28]

## Cultural significance

The Islamic State used photos of babies born with cyclopia in its recruitment campaign. ISIS claimed the photos depicted Masih ad-Dajjal, who according to the Hadith, would have only one eye. Mainstream Islamic scholars consider the prophecy as referring to a one-eyed man, not a cyclops.[29] One infant whose image was circulated in 2014 was claimed to be Israeli, but was actually Bolivian and from 2008. The baby girl from India born in 2006 (see notable cases above) also had her image used.[30]

## Gallery

### Humans

* 1616, Italy

1616, Italy

* 1634, Italy

* 1766, France

* 1893, United States

* 1900, United States

* 1909, France

* 1912, United Kingdom

* 1920, United States

* 1926, Egypt

* 1950, India

1950, India

* 1968, United States

1968, United States

* Patau syndrome

### Animals

* Cat, 1775

* Horse, 1775

* Pig from Martinique, 1775

* Goat, 1849

* Dog

* Donkey

* Sheep with in utero cyclopamine exposure

* A pig at the Hunterian Museum, Glasgow

* Cat in National Museum of Natural History

* Lissachatina immaculata

## See also

* Anophthalmia
* Hedgehog pathway

## References

1. ↑ Taber's Cyclopedic Medical Dictionary, ISBN 0-8036-0654-0
2. ↑ Leroi, Armand Marie Mutants: On Genetic Variety and the Human Body, p.73. ISBN 978-0142004821
3. ↑ Dark, Graham (2007). Rhinocephaly. In Online Medical Dictionary. Retrieved July 23, 2008.
4. ↑ "Vrolik Museum, Department of Anatomy And Embryology, University of Amsterdam". http://www.amc.uva.nl/index.cfm?pid=2668.
5. ↑ "Feline Medical Curiosities: Facial Deformities". Messybeast.com. 2007. http://www.messybeast.com/freak-face.htm.
6. ↑ "Cyclopia definition". Medical Dictionary. MedTerms. http://www.medterms.com/script/main/art.asp?articlekey=15530.
7. ↑ "Teratology Society". http://www.teratology.org/members/JMFpresentation/tsld011.htm.
8. ↑ Erich Roessler; Elena Belloni; Karin Gaudenz; Fernando Vargas; Stephen W. Scherer; Lap-Chee Tsui; Maximilian Muenke (1997). "Mutations in the C-terminal domain of Sonic Hedgehog cause holoprosencephaly". Human Molecular Genetics 6 (11): 1847–1853. doi:10.1093/hmg/6.11.1847. PMID 9302262.
9. ↑ Chin Chiang; Ying Litingtung; Eric Lee; Keith E. Young; Jeffrey L Corden; Heiner Westphal; Philip A. Beachy (1996). "Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function". Nature 383 (6599): 407–413. doi:10.1038/383407a0. PMID 8837770. Bibcode: 1996Natur.383..407C.
10. ↑ Carlson, Bruce (2014). Human Embryology and Developmental Biology (5th ed.). Elsevier. p. 309. ISBN 978-1-4557-2794-0.
11. ↑ "Observables upon a Monstrous Head". Philosophical Transactions of the Royal Society 1 (5): 85–86. 3 July 1665. doi:10.1098/rstl.1665.0037. Bibcode: 1665RSPT....1...85..
* Volume 1 – 1666 at Project Gutenberg
12. ↑ "Födde" (in sv). Kyrkbok. 1752–1800. CI:3. Glimåkra. 1793. pp. 174–175.
13. ↑ Humanities, National Endowment for the (1889-11-22). "The state rights democrat. [volume (Albany, Linn County, Oregon) 1865-1900, November 22, 1889, Image 3"]. ISSN 2470-9085. https://chroniclingamerica.loc.gov/lccn/sn84022644/1889-11-22/ed-1/seq-3/.
14. ↑ Humanities, National Endowment for the (1889-11-22). "The Corvallis gazette. [volume (Corvallis, Or.) 1862-1899, November 22, 1889, Image 4"]. ISSN 2472-4416. https://chroniclingamerica.loc.gov/lccn/sn84022650/1889-11-22/ed-1/seq-4/.
15. ↑ Humanities, National Endowment for the (1889-11-26). "The Anaconda standard. [volume (Anaconda, Mont.) 1889-1970, November 26, 1889, Morning, Image 8"]. pp. 8. ISSN 2163-4483. https://chroniclingamerica.loc.gov/lccn/sn84036012/1889-11-26/ed-1/seq-8/.
16. ↑ Humanities, National Endowment for the (1889-11-28). "The Yakima herald. [volume (North Yakima, W.T. [Wash.]) 1889-1914, November 28, 1889, Image 1"]. ISSN 2158-4745. https://chroniclingamerica.loc.gov/lccn/sn88085523/1889-11-28/ed-1/seq-1/.
17. ↑ Petty, Terrence (January 11, 2006). "Not a Hoax, One-Eyed Kitten Had Bizarre Condition". Animaldomain. LiveScience.com. http://www.livescience.com/animalworld/060111_ap_cyclops_cat.html.
18. ↑ Carney, Scott (August 10, 2006). "Cancer Drug Behind Cyclops Birth?". Condé Nast Digital. http://www.wired.com/medtech/drugs/news/2006/08/71569.
19. ↑ "Mystery of the One-Eyed Child". Condé Nast Digital. September 20, 2006. https://www.wired.com/2006/09/mystery-of-the-one-eyed-child/.
20. ↑ "Cyclops Baby Born in India Only Survives 1 Day". AOL News. http://www.aolnews.com/2011/03/24/baby-with-1-eye-and-no-nose-born-in-india-survives-1-day/.
21. ↑ "Pictures: Rare "Cyclops" Shark Found". News.nationalgeographic.com. 2011-10-13. http://news.nationalgeographic.com/news/2011/10/pictures/111013-shark-albino-one-eyed-fetus/.
22. ↑ "Viewers pitied Cleyed, the one-eyed kitten". http://doubtfulnews.com/2012/10/viewers-pitied-cleyed-the-one-eyed-kitten.
23. ↑ "Geten har ett stort jätteöga- märkliga cyklopen vördas som helig". 28 May 2017. https://www.expressen.se/tv/omtalat/geten-har-ett-stort-jatteoga--markliga-cyklopen-vordas-som-helig/.
24. ↑ "Bertahan Hidup 7 Jam, Bayi "Cyclopia" Hembuskan Nafas Terakhir". 2018-09-14. https://regional.kompas.com/read/2018/09/14/07150041/bertahan-hidup-7-jam-bayi-cyclopia-hembuskan-nafas-terakhir.
25. ↑ "One-eyed baby born in Yemen dies 7 hours later" (in en). 2022-03-19. https://gulfnews.com/world/gulf/yemen/one-eyed-baby-born-in-yemen-dies-7-hours-later-1.86570881.
26. ↑ "Cyclops pig, isinilang sa Ilocos Sur". https://www.gmanetwork.com/news/balitambayan/umg/901009/cyclops-pig-isinilang-sa-ilocos-sur/story/.
27. ↑ Lee, Yejun; Yang, Misun; Ahn, So Yoon; Sung, Se In; Chang, Yun Sil (2024-12-31). "A Case Report of Alobar Holoprosencephaly with Cyclopia and Arrhinia: The Longest-Surviving Infant without Life-Sustaining Interventions" (in en). Perinatology 35 (4): 146. doi:10.14734/PN.2024.35.4.146. https://e-kjp.org/DOIx.php?id=10.14734/PN.2024.35.4.146. Retrieved 2025-08-24.
28. ↑ Cost, Ben (2025-11-10). "Rare mutant kitten dubbed ‘cyclops cat’ is born with one eye". https://nypost.com/2025/11/10/lifestyle/rare-mutant-kitten-dubbed-cyclops-cat-is-born-with-one-eye/.
29. ↑ "Isis Use Picture of 'Cyclops Baby' to Recruit Fighters for Apocalyptic Battle". 13 September 2014. https://www.ibtimes.co.uk/isis-use-picture-cyclops-baby-recruit-fighters-apocalyptic-battle-1465323.
30. ↑ Porter, Tom (2014-09-13). "Isis Use Picture of 'Cyclops Baby' to Recruit Fighters for Apocalyptic Battle" (in en). https://www.ibtimes.co.uk/isis-use-picture-cyclops-baby-recruit-fighters-apocalyptic-battle-1465323.

## External links

Classification|

* ICD-10: Q87.0
* ICD-9-CM: 759.89

|

* v
* t
* e

Congenital abnormality syndromes

Craniofacial|

* Acrocephalosyndactylia
* Apert syndrome
* Carpenter syndrome
* Pfeiffer syndrome
* Saethre–Chotzen syndrome
* Sakati–Nyhan–Tisdale syndrome
* Bonnet–Dechaume–Blanc syndrome
* Other
* Baller–Gerold syndrome
* Cyclopia
* Goldenhar syndrome
* Möbius syndrome

Short stature|

* 1q21.1 deletion syndrome
* Aarskog–Scott syndrome
* Cockayne syndrome
* Cornelia de Lange syndrome
* Dubowitz syndrome
* Noonan syndrome
* Robinow syndrome
* Silver–Russell syndrome
* Seckel syndrome
* Smith–Lemli–Opitz syndrome
* Snyder–Robinson syndrome
* Turner syndrome

Limbs|

* Adducted thumb syndrome
* Holt–Oram syndrome
* Klippel–Trénaunay–Weber syndrome
* Nail–patella syndrome
* Rubinstein–Taybi syndrome
* Gastrulation/mesoderm:
* Caudal regression syndrome
* Ectromelia
* Sirenomelia
* VACTERL association

Overgrowth syndromes|

* Beckwith–Wiedemann syndrome
* Proteus syndrome
* Perlman syndrome
* Sotos syndrome
* Weaver syndrome
* Klippel–Trénaunay–Weber syndrome
* Benign symmetric lipomatosis
* Bannayan–Riley–Ruvalcaba syndrome
* Neurofibromatosis type I

Laurence–Moon–Bardet–Biedl|

* Bardet–Biedl syndrome
* Laurence–Moon syndrome

Combined/other,
known locus|

* 2 (Feingold syndrome)
* 3 (Zimmermann–Laband syndrome)
* 4/13 (Fraser syndrome)
* 8 (Branchio-oto-renal syndrome, CHARGE syndrome)
* 12 (Keutel syndrome, Timothy syndrome]])
* 15 (Marfan syndrome)
* 19 (Donohue syndrome)
* Multiple
* Fryns syndrome

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