National Institutes of Health

US government medical research agency

"NIH" redirects here. For other uses, see NIH (disambiguation).

National Institutes of Health (NIH)

National Institutes of Health logo

Aerial photo of the NIH Mark O. Hatfield Clinical Research Center in Bethesda, Maryland
Agency overview
Formed| August 1887; 138 years ago (1887-08)
Preceding agency|

* Hygienic Laboratory

Headquarters| Bethesda, Maryland, U.S.
39°00′09″N 77°06′16″W﻿ / ﻿39.00250°N 77.10444°W﻿ / 39.00250; -77.10444Coordinates: 39°00′09″N 77°06′16″W﻿ / ﻿39.00250°N 77.10444°W﻿ / 39.00250; -77.10444
Employees| 18,478 (2021), [1]
Annual budget| $45 billion (2022)
Agency executive|

* Lawrence A. Tabak, Acting Director

Parent agency| Department of Health & Human Services
Child agencies|

* National Cancer Institute
* National Institute of Allergy and Infectious Diseases
* National Institute of Diabetes and Digestive and Kidney Diseases
* National Heart, Lung, and Blood Institute
* National Library of Medicine

Website| www.nih.gov

The National Institutes of Health, commonly referred to as NIH, is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the late 1880s and is now part of the United States Department of Health and Human Services. Many NIH facilities are located in Bethesda, Maryland, and other nearby suburbs of the Washington metropolitan area, with other primary facilities in the Research Triangle Park in North Carolina and smaller satellite facilities located around the United States. The NIH conducts its own scientific research through the NIH Intramural Research Program (IRP) and provides major biomedical research funding to non-NIH research facilities through its Extramural Research Program.

As of 2013[update], the IRP had 1,200 principal investigators and more than 4,000 postdoctoral fellows in basic, translational, and clinical research, being the largest biomedical research institution in the world,[1] while, as of 2003, the extramural arm provided 28% of biomedical research funding spent annually in the U.S., or about US$26.4 billion.[2]

The NIH comprises 27 separate institutes and centers of different biomedical disciplines and is responsible for many scientific accomplishments, including the discovery of fluoride to prevent tooth decay, the use of lithium to manage bipolar disorder, and the creation of vaccines against hepatitis, Haemophilus influenzae (HIB), and human papillomavirus (HPV).[3]

In 2019, the NIH was ranked number two in the world, behind Harvard University, for biomedical sciences in the Nature Index, which measured the largest contributors to papers published in a subset of leading journals from 2015 to 2018.[4][5]

## Contents

* 1 History
* 1.1 Origins
* 1.2 Later history
* 2 Leadership
* 3 Locations and campuses
* 4 Research
* 4.1 Intramural and extramural research
* 4.2 Public Access Policy
* 4.3 Economic return
* 4.4 Notable discoveries and developments
* 4.4.1 NIH Toolbox
* 4.4.2 Database of Genotypes and Phenotypes
* 4.4.3 Coronavirus vaccine
* 4.4.4 Collaboration with Wuhan Institute of Virology
* 4.4.5 NIH Interagency Pain Research Coordinating Committee
* 5 Funding
* 5.1 Budget and politics
* 5.1.1 Historical funding
* 5.2 Extramural research
* 5.3 Funding criteria
* 5.3.1 Gender and sex bias
* 5.4 Stakeholders
* 5.4.1 General public
* 5.4.2 Extramural researchers and scientists
* 6 Commercial partnerships
* 7 Institutes and centers
* 8 ARPA-H
* 9 Previous directors
* 10 See also
* 11 References
* 12 External links

## History

[edit | edit source]

### Origins

[edit | edit source]

Ida A. Bengtson, a bacteriologist who in 1916 was the first woman hired to work in the Hygienic Laboratory[6] Dedication of first six NIH buildings by President Franklin D. Roosevelt in 1940 NIH campus in Bethesda, Maryland, in 1945

In 1887, a laboratory for the study of bacteria, the Hygienic Laboratory, was established within the Marine Hospital Service, which at the time was expanding its functions beyond the system of Marine Hospitals into quarantine and research programs. It was initially located at the New York Marine Hospital on Staten Island.[7][8][9] In 1891, it moved to the top floor of the Butler Building in Washington, D.C. In 1904, it moved again to a new campus at the Old Naval Observatory, which grew to include five major buildings.[10]

In 1901, the Division of Scientific Research was formed, which included the Hygienic Laboratory as well as other research offices of the Marine Hospital Service.[11] In 1912, the Marine Hospital Service became the Public Health Service (PHS).[9] In 1922, PHS established a Special Cancer Investigations laboratory at Harvard Medical School. This marked the beginning of a partnership with universities.[9]

In 1930, the Hygienic Laboratory was re-designated as the National Institute of Health by the Ransdell Act, and was given $750,000 to construct two NIH buildings at the Old Naval Observatory campus.[9] In 1937, NIH absorbed the rest of the Division of Scientific Research, of which it was formerly part.[11][12]

In 1938, NIH moved to its current campus in Bethesda, Maryland.[9] Over the next few decades, Congress would markedly increase funding of the NIH, and various institutes and centers within the NIH were created for specific research programs.[9] In 1944, the Public Health Service Act was approved, and the National Cancer Institute became a division of NIH. In 1948, the name changed from National Institute of Health to National Institutes of Health.

### Later history

[edit | edit source]

In the 1960s, virologist and cancer researcher Chester M. Southam injected HeLa cancer cells into patients at the Jewish Chronic Disease Hospital.[13]: 130 When three doctors resigned after refusing to inject patients without their consent, the experiment gained considerable media attention.[13]: 133 The NIH was a major source of funding for Southam's research and had required all research involving human subjects to obtain their consent prior to any experimentation.[13]: 135 Upon investigating all of their grantee institutions, the NIH discovered that the majority of them did not protect the rights of human subjects. From then on, the NIH has required all grantee institutions to approve any research proposals involving human experimentation with review boards.[13]: 135

In 1967, the Division of Regional Medical Programs was created to administer grants for research for heart disease, cancer, and strokes. That same year, the NIH director lobbied the White House for increased federal funding in order to increase research and the speed with which health benefits could be brought to the people. An advisory committee was formed to oversee the further development of the NIH and its research programs. By 1971 cancer research was in full force and President Nixon signed the National Cancer Act, initiating a National Cancer Program, President's Cancer Panel, National Cancer Advisory Board, and 15 new research, training, and demonstration centers.[14]

Funding for the NIH has often been a source of contention in Congress, serving as a proxy for the political currents of the time. In 1992, the NIH encompassed nearly 1 percent of the federal government's operating budget and controlled more than 50 percent of all funding for health research, and 85 percent of all funding for health studies in universities.[15] While government funding for research in other disciplines has been increasing at a rate similar to inflation since the 1970s, research funding for the NIH nearly tripled through the 1990s and early 2000s, but has remained relatively stagnant since then.[16]

By the 1990s, the NIH committee focus had shifted to DNA research and launched the Human Genome Project.[17]

## Leadership

[edit | edit source]

The NIH Office of the Director is the central office responsible for setting policy for NIH, and for planning, managing, and coordinating the programs and activities of all NIH components. The NIH Director plays an active role in shaping the agency's activities and outlook. The Director is responsible for providing leadership to the Institutes and Centers by identifying needs and opportunities, especially in efforts involving multiple Institutes.[18] Within the Director's Office is the Division of Program Coordination, Planning and Strategic Initiatives with 12 divisions including:

* Office of AIDS Research
* Office of Research on Women's Health
* Office of Disease Prevention
* Sexual and Gender Minority Research Office
* Tribal Health Research Office
* Office of Program Evaluation and Performance

The Agency Intramural Research Integrity Officer "is directly responsible for overseeing the resolution of all research misconduct allegations involving intramural research, and for promoting research integrity within the NIH Office of Intramural Research (OIR)."[19] There is a Division of Extramural Activities, which has its own Director.[20] The Office of Ethics has its own Director,[21] as does the Office of Global Research.[22]

## Locations and campuses

[edit | edit source]

Intramural research is primarily conducted at the main campus in Bethesda, Maryland, and Rockville, Maryland, and the surrounding communities.

Clinical Research Center at NIH Main Lobby Wall at the Clinical Research Center at NIH Looking at the Main Lobby at the Clinical Research Center at NIH Looking at the Main Lobby at the Clinical Research Center at NIH

The Bayview Campus in Baltimore, Maryland houses the research programs of the National Institute on Aging, National Institute on Drug Abuse, and National Human Genome Research Institute with nearly 1,000 scientists and support staff.[23] The Frederick National Laboratory in Frederick, MD and the nearby Riverside Research Park, houses many components of the National Cancer Institute, including the Center for Cancer Research, Office of Scientific Operations, Management Operations Support Branch, the division of Cancer Epidemiology and Genetics and the division of Cancer Treatment and Diagnosis.[24]

The National Institute of Environmental Health Sciences is located in the Research Triangle region of North Carolina.

Other ICs have satellite locations in addition to operations at the main campus. The National Institute of Allergy and Infectious Diseases maintains its Rocky Mountain Labs in Hamilton, Montana,[25] with an emphasis on BSL3 and BSL4 laboratory work. NIDDK operates the Phoenix Epidemiology and Clinical Research Branch in Phoenix, Arizona.

## Research

[edit | edit source]

Clinical Center – Building 10

As of 2017, 153 scientists receiving financial support from the NIH have been awarded a Nobel Prize and 195 have been awarded a Lasker Award.[26]

### Intramural and extramural research

[edit | edit source]

NIH devotes 10% of its funding to research within its own facilities (intramural research), and gives >80% of its funding in research grants to extramural (outside) researchers.[27] Of this extramural funding, a certain percentage (2.8% in 2014) must be granted to small businesses under the SBIR/STTR program.[28] As of 2011[update], the extramural funding consisted of about 50,000 grants to more than 325,000 researchers at more than 3000 institutions.[29] By 2018[update], this rate of granting remained reasonably steady, at 47,000 grants to 2,700 organizations.[27] In FY 2010[update], NIH spent US$10.7bn (not including temporary funding from the American Recovery and Reinvestment Act of 2009) on clinical research, US$7.4bn on genetics-related research, US$6.0bn on prevention research, US$5.8bn on cancer, and US$5.7bn on biotechnology.[30]

### Public Access Policy

[edit | edit source]

Main article: NIH Public Access Policy

In 2008 a Congressional mandate called for investigators funded by the NIH to submit an electronic version of their final manuscripts to the National Library of Medicine's research repository, PubMed Central (PMC), no later than 12 months after the official date of publication.[31] The NIH Public Access Policy was the first public access mandate for a U.S. public funding agency.[32]

### Economic return

[edit | edit source]

In 2000, the Joint Economic Committee of Congress reported NIH research, which was funded at $16 billion a year in 2000, that some econometric studies had given a rate of return of 25 to 40 percent per year by reducing the economic cost of illness in the US. It found that of the 21 drugs with the highest therapeutic impact on society introduced between 1965 and 1992, public funding was "instrumental" for 15.[33] As of 2011 NIH-supported research helped to discover 153 new FDA-approved drugs, vaccines, and new indications for drugs in the 40 years prior.[34] One study found NIH funding aided either directly or indirectly in developing the drugs or drug targets for all of the 210 FDA-approved drugs from 2010 to 2016.[35] In 2015, Pierre Azoulay et al. estimated $10 million invested in research generated two to three new patents.[36]

### Notable discoveries and developments

[edit | edit source]

Since its inception, the NIH intramural research program has been a source of many pivotal scientific and medical discoveries. Some of these include:

* 1908: George W. McCoy's discovery that rodents were a reservoir of bubonic plague.
* 1911: George W. McCoy, Charles W. Chapin, William B. Wherry, and B. H. Lamb described the previously unknown tularemia.
* 1924: Roscoe R. Spencer and Ralph R. Parker developed a vaccine against Rocky Mountain spotted fever.
* 1930: Sanford M. Rosenthal developed a treatment for mercury poisoning used widely before the development of dimercaptoethanol.
* 1943: Wilton R. Earle pioneered the cell culture process and published a paper describing the production of malignancy in vitro, Katherine K. Sanford developed the first clone from an isolated cancer cell, and Virginia J. Evans devised a medium that supported growth of cells in vitro.
* 1940s–1950s: Bernard Horecker and colleagues described the pentose phosphate pathway.
* 1950s: Julius Axelrod discovered a new class of enzymes, cytochrome P450 monooxygenases, a fundamental of drug metabolism.
* 1950: Earl Stadtman discovered phosphotransacetylose, elucidating the role of acetyl CoA in fatty acid metabolism.
* 1960s: Discovered the first human slow virus disease, kuru, which is a degenerative, fatal infection of the central nervous system. This discovery of a new mechanism for infectious diseases revolutionized thinking in microbiology and neurology.
* 1960s: Defined the mechanisms that regulate noradrenaline, one of the most important neurotransmitters in the brain.
* 1960s: Developed the first licensed rubella vaccine and the first test for rubella antibodies for large scale testing.
* 1960s: Developed an effective combination drug regimen for Hodgkin's lymphoma.
* 1960s: Discovery that tooth decay is caused by bacteria.
* 1970s: Developed the assay for human chorionic gonadotropin that evolved into the home pregnancy tests.
* 1970s: Described the hormonal cycle involved in menstruation.
* 1980s: Determined the complete structure of the IgE receptor that is involved in allergic reactions.
* 1990s: First trial of gene therapy in humans.

#### NIH Toolbox

[edit | edit source]

In September 2006, the NIH Blueprint for Neuroscience Research started a contract for the NIH Toolbox for the Assessment of Neurological and Behavioral Function to develop a set of state-of-the-art measurement tools to enhance collection of data in large cohort studies. Scientists from more than 100 institutions nationwide contributed. In September 2012, the NIH Toolbox was rolled out to the research community. NIH Toolbox assessments are based, where possible, on Item Response Theory and adapted for testing by computer.[citation needed]

#### Database of Genotypes and Phenotypes

[edit | edit source]

NIH sponsors the Database of Genotypes and Phenotypes (dbGaP), a repository of information produced by studies investigating the interaction of genotype and phenotype. The information includes phenotypes, molecular assay data, analyses and documents. Summary-level data is available to the general public whereas the individual-level data is accessible to researchers.[37] According to the City Journal NIH denies access to such attributes as intelligence, education and health on the grounds that studying their genetic basis would be stigmatizing.[38]

#### Coronavirus vaccine

[edit | edit source]

The NIH partnered with Moderna in 2020 during the COVID-19 pandemic to develop a vaccine. The final phase of testing began on July 27 with up to 30,000 volunteers assigned to one of two groups—one receiving the mRNA-1273 vaccine and the other receiving salt water injections—and continued until there had been approximately 100 cases of COVID-19 among the participants.[39][40] In 2021, the NIH contributed $4,395,399 towards the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) program.[41]

#### Collaboration with Wuhan Institute of Virology

[edit | edit source]

See also: COVID-19 lab leak theory and Investigations into the origin of COVID-19

Following the outbreak of the COVID-19 pandemic, NIH-funded EcoHealth Alliance has been the subject of controversy and increased scrutiny due to its ties to the Wuhan Institute of Virology (WIV)—which has been at the center of speculation since early 2020 that SARS-CoV-2 may have escaped in a lab incident.[42][43][44][45][46] Under political pressure, the NIH withdrew funding to EcoHealth Alliance in July 2020.[47]

#### NIH Interagency Pain Research Coordinating Committee

[edit | edit source]

On February 13, 2012, the National Institutes of Health (NIH) announced a new group of individuals assigned to research pain. This committee is composed of researchers from different organizations and will focus to "coordinate pain research activities across the federal government with the goals of stimulating pain research collaboration… and providing an important avenue for public involvement" ("Members of new", 2012). With a committee such as this research will not be conducted by each individual organization or person but instead a collaborating group which will increase the information available. With this hopefully more pain management will be available including techniques for those with arthritis.[48] In 2020 Beth Darnall, American scientist and pain psychologist, was appointed as scientific member of the group.

## Funding

[edit | edit source]

### Budget and politics

[edit | edit source]

Historical NIH budget[49] Year  | Budget (millions)

|

1938  | 0.5
1940  | 0.7
1945  | 2.8
1950  | 52.7
1955  | 81.2
1960  | 399.4
1965  | 959.2
1970  | 1,061.0
1975  | 2,092.9
1980  | 3,428.9
1985  | 5,149.5
1990  | 7,567.4
1995  | 11,299.5
2000  | 17,840.5
2005  | 28,594.4
2010  | 31,238.0
2015  | 30,311.4
2016  | 32,311.4
2017  | 34,300.9
2018  | 37,311.3
2019  | 39,000.0
2020  | 42,000.0

To allocate funds, the NIH must first obtain its budget from Congress. This process begins with institute and center (IC) leaders collaborating with scientists to determine the most important and promising research areas within their fields. IC leaders discuss research areas with NIH management who then develops a budget request for continuing projects, new research proposals, and new initiatives from the Director. NIH submits its budget request to the Department of Health and Human Services (HHS), and the HHS considers this request as a portion of its budget. Many adjustments and appeals occur between NIH and HHS before the agency submits NIH's budget request to the Office of Management and Budget (OMB). OMB determines what amounts and research areas are approved for incorporation into the President's final budget. The President then sends NIH's budget request to Congress in February for the next fiscal year's allocations.[50] The House and Senate Appropriations Subcommittees deliberate and by fall, Congress usually appropriates funding. This process takes approximately 18 months before the NIH can allocate any actual funds.[51]

When a government shutdown occurs, the NIH continues to treat people who are already enrolled in clinical trials, but does not start any new clinical trials and does not admit new patients who are not already enrolled in a clinical trial, except for the most critically ill, as determined by the NIH Director.[52][53][54][55]

#### Historical funding

[edit | edit source]

Over the last century, the responsibility to allocate funding has shifted from the OD and Advisory Committee to the individual ICs and Congress increasingly set apart funding for particular causes. In the 1970s, Congress began to earmark funds specifically for cancer research, and in the 1980s there was a significant amount allocated for AIDS/HIV research.[56]

Funding for the NIH has often been a source of contention in Congress, serving as a proxy for the political currents of the time. During the 1980s, President Reagan repeatedly tried to cut funding for research, only to see Congress partly restore funding. The political contention over NIH funding slowed the nation's response to the AIDS epidemic; while AIDS was reported in newspaper articles from 1981, no funding was provided for research on the disease. In 1984 National Cancer Institute scientists found implications that "variants of a human cancer virus called HTLV-III are the primary cause of acquired immunodeficiency syndrome (AIDS)," a new epidemic that gripped the nation.[57]

In 1992, the NIH encompassed nearly 1 percent of the federal government's operating budget and controlled more than 50 percent of all funding for health research and 85 percent of all funding for health studies in universities.[15] From 1993 to 2001 the NIH budget doubled. For a time, funding essentially remained flat, and for seven years following the financial crisis, the NIH budget struggled to keep up with inflation.[58]

In 1999 Congress increased the NIH's budget by $2.3 billion[56] to $17.2 billion in 2000.[59] In 2009 Congress again increased the NIH budget to $31 billion in 2010.[59] In 2017 and 2018, Congress passed laws with bipartisan support that substantially increasing appropriations for NIH, which was 37.3 billion dollars annually in FY2018.[60][61]

### Extramural research

[edit | edit source]

Main article: NIH grant

Researchers at universities or other institutions outside of NIH can apply for research project grants (RPGs) from the NIH. There are numerous funding mechanisms for different project types (e.g., basic research, clinical research, etc.) and career stages (e.g., early career, postdoc fellowships, etc.). The NIH regularly issues "requests for applications" (RFAs), e.g., on specific programmatic priorities or timely medical problems (such as Zika virus research in early 2016). In addition, researchers can apply for "investigator-initiated grants" whose subject is determined by the scientist.

The total number of applicants has increased substantially, from about 60,000 investigators who had applied during the period from 1999 to 2003 to slightly less than 90,000 in who had applied during the period from 2011 to 2015.[62] Due to this, the "cumulative investigator rate", that is, the likelihood that unique investigators are funded over a 5-year window, has declined from 43% to 31%.[62]

R01 grants are the most common funding mechanism and include investigator-initiated projects. The roughly 27,000 to 29,000 R01 applications had a funding success of 17-19% during 2012 though 2014. Similarly, the 13,000 to 14,000 R21 applications had a funding success of 13-14% during the same period.[63] In FY 2016, the total number of grant applications received by the NIH was 54,220, with approximately 19% being awarded funding.[64] Institutes have varying funding rates. The National Cancer Institute awarded funding to 12% of applicants, while the National Institute for General Medical Science awarded funding to 30% of applicants.[64]

### Funding criteria

[edit | edit source]

NIH employs five broad decision criteria in its funding policy. First, ensure the highest quality of scientific research by employing an arduous peer review process. Second, seize opportunities that have the greatest potential to yield new knowledge and that will lead to better prevention and treatment of disease. Third, maintain a diverse research portfolio in order to capitalize on major discoveries in a variety of fields such as cell biology, genetics, physics, engineering, and computer science. Fourth, address public health needs according to the disease burden (e.g., prevalence and mortality). And fifth, construct and support the scientific infrastructure (e.g., well-equipped laboratories and safe research facilities) necessary to conduct research.[65]

Advisory committee members advise the institute on policy and procedures affecting the external research programs and provide a second level of review for all grant and cooperative agreement applications considered by the Institute for funding.[66]

#### Gender and sex bias

[edit | edit source]

In 2014, it was announced that the NIH is directing scientists to perform their experiments with both female and male animals, or cells derived from females as well as males if they are studying cell cultures, and that the NIH would take the balance of each study design into consideration when awarding grants.[67] The announcement also stated that this rule would probably not apply when studying sex-specific diseases (for example, ovarian or testicular cancer).[67]

### Stakeholders

[edit | edit source]

#### General public

[edit | edit source]

One of the goals of the NIH is to "expand the base in medical and associated sciences in order to ensure a continued high return on the public investment in research."[68] Taxpayer dollars funding NIH are from the taxpayers, making them the primary beneficiaries of advances in research. Thus, the general public is a key stakeholder in the decisions resulting from the NIH funding policy.[69][failed verification] However, some in the general public do not feel their interests are being represented, and individuals have formed patient advocacy groups to represent their own interests.[70]

#### Extramural researchers and scientists

[edit | edit source]

Important stakeholders of the NIH funding policy include researchers and scientists. Extramural researchers differ from intramural researchers in that they are not employed by the NIH but may apply for funding. Throughout the history of the NIH, the amount of funding received has increased, but the proportion to each IC remains relatively constant. The individual ICs then decide who will receive the grant money and how much will be allotted.

Policy changes on who receives funding significantly affect researchers. For example, the NIH has recently attempted to approve more first-time NIH R01 applicants or the research grant applications of young scientists. To encourage the participation of young scientists, the application process has been shortened and made easier.[71] In addition, first-time applicants are being offered more funding for their research grants than those who have received grants in the past.[72]

## Commercial partnerships

[edit | edit source]

In 2011 and 2012, the Department of Health and Human Services Office of Inspector General published a series of audit reports revealing that throughout the fiscal years 2000–2010, institutes under the aegis of the NIH did not comply with the time and amount requirements specified in appropriations statutes, in awarding federal contracts to commercial partners, committing the federal government to tens of millions of dollars of expenditure ahead of appropriation of funds from Congress.[73]

## Institutes and centers

[edit | edit source]

Main article: List of NIH ICs

The NIH is composed of 27 separate institutes and centers (ICs) that conduct and coordinate research across different disciplines of biomedical science. These are:

* National Cancer Institute (NCI)
* National Eye Institute (NEI)
* National Heart, Lung, and Blood Institute (NHLBI)
* National Human Genome Research Institute (NHGRI)
* National Institute on Aging (NIA)
* National Institute on Alcohol Abuse and Alcoholism (NIAAA)
* National Institute of Allergy and Infectious Diseases (NIAID)
* National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
* National Institute of Biomedical Imaging and Bioengineering (NIBIB)
* National Institute of Child Health and Human Development (NICHD[74])
* National Institute on Deafness and Other Communication Disorders (NIDCD)
* National Institute of Dental and Craniofacial Research (NIDCR)
* National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
* National Institute on Drug Abuse (NIDA)
* National Institute of Environmental Health Sciences (NIEHS)
* National Institute of General Medical Sciences (NIGMS)
* National Institute of Mental Health (NIMH)
* National Institute on Minority Health and Health Disparities (NIMHD)
* National Institute of Neurological Disorders and Stroke (NINDS)
* National Institute of Nursing Research (NINR)
* National Library of Medicine (NLM)
* Center for Information Technology (CIT)
* Center for Scientific Review (CSR)
* Fogarty International Center (FIC)
* National Center for Advancing Translational Sciences (NCATS)
* National Center for Complementary and Integrative Health (NCCIH)
* NIH Clinical Center (NIH CC)

In addition, the National Center for Research Resources operated from April 13, 1962, to December 23, 2011.

## ARPA-H

[edit | edit source]

Main article: Advanced Research Projects Agency for Health

The Advanced Research Projects Agency for Health (ARPA-H) is an entity formerly within the Office of the United States Secretary of Health and Human Services, which was created by Congress in the Consolidated Appropriations Act, 2022.[75] Modeled after DARPA, HSARPA, IARPA, and ARPA-E, it is intended to pursue unconventional research projects through methods not typically used by federal agencies or private sector companies. Secretary Xavier Becerra delegated ARPA-H to the NIH on May 24, 2022.[76][77][78] It received $1 billion in appropriations in 2022, and $1.5 billion in 2023, and as of June 2023[update] it is requesting $2.5 billion for 2024.[79][80]

## Previous directors

[edit | edit source]

Source: [81]

Portrait  | Directors  | Took office  | Left office

|
|
|

| Joseph J. Kinyoun | August 1887  | April 30, 1899
| Milton J. Rosenau | May 1, 1899  | September 30, 1909
| John F. Anderson | October 1, 1909  | November 19, 1915
| George W. McCoy | November 20, 1915  | January 31, 1937
| Lewis Ryers Thompson | February 1, 1937  | January 31, 1942
| Rolla Dyer | February 1, 1942  | September 30, 1950
| William H. Sebrell Jr. | October 1, 1950  | July 31, 1955
| James A. Shannon | August 1, 1955  | August 31, 1968
| Robert Q. Marston | September 1, 1968  | January 21, 1973
| John F. Sherman (acting)  | January 21, 1973  | May 28, 1973
| Robert Stone | May 29, 1973  | January 31, 1975
| Ronald W. Lamont-Havers (acting)  | February 1, 1975  | June 30, 1975
| Donald S. Fredrickson | July 1, 1975  | June 30, 1981
| Thomas E. Malone  | July 1, 1981  | April 28, 1982
| James Wyngaarden | April 29, 1982  | July 31, 1989
| William F. Raub (acting)  | August 1, 1989  | April 8, 1991
| Bernadine Healy | April 9, 1991  | July 30, 1993
| Ruth L. Kirschstein (acting)  | July 1, 1993  | November 22, 1993
| Harold E. Varmus | November 23, 1993  | December 31, 1999
| Ruth L. Kirschstein (acting)  | January 1, 2000  | May 2, 2002
| Elias Zerhouni | May 2, 2002  | October 31, 2008
| Raynard S. Kington (acting)  | October 31, 2008  | August 16, 2009
| Francis S. Collins | August 17, 2009  | December 19, 2021
| Lawrence A. Tabak (acting)  | December 20, 2021  | Present

## See also

[edit | edit source]

* List of institutes and centers of the National Institutes of Health
* United States Public Health Service
* Foundation for the National Institutes of Health
* National Institutes of Health Stroke Scale
* Heads of International Research Organizations
* NIH Toolbox
* National Institute of Food and Agriculture
* Biomedical Engineering and Instrumentation Program (BEIP)

## References

[edit | edit source]

1. ^ "Organization and Leadership | NIH Intramural Research Program". Irp.nih.gov. April 4, 2011. Archived from the original on April 24, 2013. Retrieved April 28, 2013.
2. ^ Osterweil, Neil (September 20, 2005). "Medical Research Spending Doubled Over Past Decade". MedPage Today. Archived from the original on October 16, 2015. Retrieved September 15, 2015.
3. ^ NIH Sourcebook "Archived copy" (PDF). Archived from the original (PDF) on January 5, 2012. Retrieved January 20, 2012.`{{cite web}}`: CS1 maint: archived copy as title (link)
4. ^ "The top 10 institutions in biomedical sciences in 2018". Retrieved May 28, 2019.
5. ^ "Introduction to the Nature Index". natureindex.com.
6. ^ Harden, Victoria A. "WWI and the Ransdell Act of 1930". A Short History of the National Institutes of Health. Office Of History National Institutes Of Health, United States National Institutes of Health. Archived from the original on September 7, 2011. Retrieved September 12, 2011.
7. ^ "A Short History of the National Institutes of Health (1 of 13)". history.nih.gov. Archived from the original on May 15, 2011. Retrieved May 25, 2011.
8. ^ "SIC 9431 Administration of Public Health Programs". Referenceforbusiness.com. Archived from the original on May 10, 2011. Retrieved May 25, 2011.
9. ^ a b c d e f NIH Almanac 2011, History: Chronology of Events: 1800– harvnb error: no target: CITEREFNIH_Almanac2011 (help)
10. ^ Harden, Victoria A.; Lyons, Michele (February 27, 2018). "NIH's Early Homes". NIH Intramural Research Program. Retrieved December 13, 2020.
11. ^ a b "Records of the Public Health Service [PHS], 1912-1968". National Archives. August 15, 2016. Retrieved April 23, 2021.`{{cite web}}`: CS1 maint: url-status (link)
12. ^ Doyle, Henry N. (1977). "The federal industrial hygiene agency: a history of the Division of Occupational Health, United States Public Health Service" (PDF). American Conference of Governmental Industrial Hygienists. Archived (PDF) from the original on October 13, 2021. Retrieved September 3, 2020.
13. ^ a b c d Skloot, Rebecca (2010). The Immortal Life of Henrietta Lacks. New York: Broadway Paperbacks.
14. ^ "History of the National Cancer Institute". National Cancer Institute - National Institutes of Health. March 18, 2015. Archived from the original on June 28, 2017. Retrieved June 29, 2017.
15. ^ a b Laurie J. Price (1992). "A Medical Anthropologist's Ruminations on NIH Funding". Medical Anthropology Quarterly. New Series. 6 (2): 128–146. doi:10.1525/maq.1992.6.2.02a00030. JSTOR 649307.
16. ^ "Historical Trends in Federal R&D". AAAS - The World's Largest General Scientific Society. June 11, 2013. Archived from the original on January 10, 2018.
17. ^ "Online Education Kit: 1990: Launch of the Human Genome Project". National Human Genome Research Institute (NHGRI). Retrieved November 26, 2018.
18. ^ "NIH Leadership". National Institutes of Health (NIH). October 31, 2014. Retrieved March 18, 2019. This article incorporates text from this source, which is in the public domain.
19. ^ "Kathryn M. Partin, Ph.D." National Institutes of Health. May 27, 2021.
20. ^ "Division of Extramural Activities - Contacts". National Institutes of Health. May 28, 2021.
21. ^ "Office of Ethics (OE) - Contacts". National Institutes of Health. June 17, 2009.
22. ^ "Global Research - Contacts". National Institutes of Health. April 26, 2021.
23. ^ "Bayview Campus". nih.gov. May 8, 2013. Archived from the original on September 5, 2017. Retrieved May 7, 2018.
24. ^ "NCI at Frederick: About the NCI at Frederick". ncifrederick.cancer.gov. Archived from the original on January 10, 2018.
25. ^ "Division of Intramural Research Overview". National Institute of Allergy and Infectious Diseases. September 1, 2010. Archived from the original on March 8, 2010. Retrieved September 15, 2015.
26. ^ "Lasker Awards". National Institutes of Health (NIH). February 5, 2016. Archived from the original on July 5, 2016.
27. ^ a b Philippidis, Alex (September 2019). "Top 25 NIH-Funded Institutions". Genetic Engineering & Biotechnology News. Vol. 39, no. 9\. p. 16. Retrieved September 14, 2019.
28. ^ Garland, Eva (2014). Winning SBIR/STTR Grants: A Ten Week Plan for Preparing Your NIH Phase I Application. ISBN 978-1494784447.
29. ^ "NIH Budget". National Institutes of Health. National Institutes of Health. May 23, 2011. Archived from the original on August 26, 2011. Retrieved August 26, 2011.
30. ^ "Estimates of Funding for Various Research, Condition, and Disease Categories (RCDC)". Research Portfolio Online Reporting Tools. National Institutes of Health. March 15, 2011. Archived from the original on August 13, 2011. Retrieved August 26, 2011.
31. ^ National Institutes of Health. "NIH Public Access Policy Details". National Institutes of Health. Archived from the original on November 1, 2011. Retrieved January 30, 2014.
32. ^ Suber, Peter (April 16, 2008). "An open access mandate for the National Institutes of Health". Open Medicine. 2 (2): e39–41. PMC 3090178. PMID 21602938.
33. ^ "The Benefits of Medical Research and the Role of the NIH" (PDF). U.S. Joint Economic Committee. May 2000. Archived from the original (PDF) on April 12, 2015. Retrieved May 25, 2011.
34. ^ Stevens, A. J.; Jensen, J. J.; Wyller, K.; Kilgore, P. C.; Chatterjee, S.; Rohrbaugh, M. L. (2011). "The Role of Public-Sector Research in the Discovery of Drugs and Vaccines". New England Journal of Medicine. 364 (6): 535–541. doi:10.1056/NEJMsa1008268. PMID 21306239.
35. ^ "NIH funding contributed to 210 approved drugs in recent years, study says". statnews.com. February 12, 2018. Archived from the original on March 22, 2018. Retrieved May 7, 2018.
36. ^ Azoulay, Pierre; Graff Zivin, Joshua S.; Li, Danielle; Sampat, Bhaven N. (January 2015). "Public R&D Investments and Private-sector Patenting: Evidence from NIH Funding Rules". NBER Working Paper No. 20889. doi:10.3386/w20889.
37. ^ Tryka, K. A.; Hao, L.; Sturcke, A.; Jin, Y.; Wang, Z. Y.; Ziyabari, L.; Lee, M.; Popova, N.; Sharopova, N.; Kimura, M.; Feolo, M. (January 1, 2014). "NCBI's Database of Genotypes and Phenotypes: dbGaP". Nucleic Acids Research. 42 (D975–D979): D975–D979. doi:10.1093/nar/gkt1211. PMC 3965052. PMID 24297256.
38. ^ Lee, James (October 19, 2022). "Don't Even Go There". City Journal. Retrieved January 10, 2023.
39. ^ Palca, Joe (July 27, 2020). "COVID-19 Vaccine Candidate Heads To Widespread Testing In U.S." NPR. NPR.
40. ^ Staff Writer (November 16, 2020). "Promising Interim Results from Clinical Trial of NIH-Moderna COVID-19 Vaccine". National Institutes of Health. U.S. Department of Health and Human Services. Retrieved June 23, 2021.
41. ^ "2021 Statutory Report" (PDF). Foundation for the National Institutes of Health. May 2022. Archived (PDF) from the original on September 16, 2022. Retrieved September 15, 2022.
42. ^ "Fauci Was 'Untruthful' to Congress About Wuhan Lab Research, New Documents Appear To Show". Newsweek. September 9, 2021.
43. ^ "Wuhan, U.S. Scientists Planned to Make Coronaviruses, Documents Leaked by DRASTIC Show". Newsweek. October 8, 2021.
44. ^ "In Major Shift, NIH Admits Funding Risky Virus Research in Wuhan". Vanity Fair. October 22, 2021.
45. ^ "NIH says grantee failed to report experiment in Wuhan that created a bat virus that made mice sicker". Science. October 21, 2021.
46. ^ "Fauci stands by gain-of-function research denials, defends collaboration with Wuhan lab". The Denver Gazette. October 24, 2021.
47. ^ "NIH Presses U.S. Nonprofit for Information on Wuhan Virology Lab". Wall Street Journal. Retrieved June 6, 2021.
48. ^ "Members of new Interagency Pain Research Coordinating Committee announced". nih.gov. February 13, 2012. Retrieved July 13, 2019.
49. ^ "Appropriations". National Institutes of Health (NIH). Retrieved March 17, 2019.
50. ^ "Funding" (PDF). Archived (PDF) from the original on March 4, 2016.
51. ^ "Funding". Archived from the original on December 7, 2011.
52. ^ Sabrina Tavernese (October 9, 2013). "Clinical Trials Continue, but Only at a Crawl". New York Times. Archived from the original on November 4, 2017.
53. ^ Neergaard, Lauran (October 9, 2013). "NIH admits a dozen critically ill, making exceptions to no-new-patient policy during shutdown". Huffington Post. The Associated Press. Archived from the original on March 1, 2017. Retrieved September 10, 2015.
54. ^ "Government slimdown blocks some seeking NIH research treatment". Fox News Channel. The Associated Press. October 2, 2013. Archived from the original on October 5, 2013.
55. ^ "Department of Health and Human Services Fiscal Year 2014 Contingency Staffing Plan for Operations in the Absence of Enacted Annual Appropriations" (PDF). Archived from the original (PDF) on October 28, 2013.
56. ^ a b NIH Almanac 2011, History: Legislative Chronology: Funding harvnb error: no target: CITEREFNIH_Almanac2011 (help)
57. ^ NIH Almanac 2011, History: Chronology of Events: 1980– harvnb error: no target: CITEREFNIH_Almanac2011 (help)
58. ^ NIH Appropriations (Section 1) Archived May 7, 2017, at the Wayback Machine and NIH Appropriations (Section 2) Archived January 5, 2018, at the Wayback Machine April 7, 2016, retrieved May 4, 2016, U.S. Department of Health and Human Service
59. ^ a b "Funding" (PDF). Archived (PDF) from the original on February 15, 2013.
60. ^ Office of Management and Budget America First. A Budget Blueprint to Make America Great Again. Archived May 4, 2017, at the Wayback Machine Budget of the United States Government, Fiscal Year 2018. Government Publishing Office, March 16, 2017.65 pp
61. ^ "NIH Funding: FY1994-FY2019" (PDF). Congressional Research Service. Archived (PDF) from the original on March 28, 2014. Retrieved March 17, 2017.
62. ^ a b Lauer, Mike (May 31, 2016). "How Many Researchers?". Open Mike. NIH. Archived from the original on August 25, 2016. Retrieved June 6, 2016.
63. ^ Rockey, Sally (April 10, 2015). "Looking at Recent Data on R21 and R01-equivalent Grants". Rock Talk. NIH. Archived from the original on October 8, 2016. Retrieved October 2, 2016.
64. ^ a b "NIH Research Portfolio Online Reporting Tools (RePORT)". report.nih.gov. Archived from the original on February 2, 2018.
65. ^ "Statement on Funding Allocation for Disease Research by Harold Varmus, M. D., Director, National Institutes of Health". Assistant Secretary for Legislation, Department of Health and Human Services. May 6, 1999.
66. ^ "National Advisory Neurological Disorders and Stroke Council (NANDSC)". Ninds.nih.gov. Archived from the original on April 28, 2013. Retrieved April 28, 2013.
67. ^ a b Rabin, Roni Caryn (May 14, 2014). "Labs Are Told to Start Including a Neglected Variable: Females". The New York Times. Archived from the original on September 6, 2015. Retrieved September 10, 2015.
68. ^ "Stakeholders". October 31, 2014. Archived from the original on November 25, 2011.
69. ^ "Stakeholders". Archived from the original on November 14, 2011.
70. ^ "Stakeholders". Archived from the original on November 4, 2016.
71. ^ Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE (2008). "Changes to NIH grant system may backfire". Science. 322 (5905): 1187–8. doi:10.1126/science.322.5905.1187c. PMID 19023064. S2CID 47509185.
72. ^ Costello LC (May 2010). "Perspective: is NIH funding the "best science by the best scientists"? A critique of the NIH R01 research grant review policies". Acad Med. 85 (5): 775–9. doi:10.1097/ACM.0b013e3181d74256. PMID 20520024.
73. ^ "Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract N01-AI-15416 With the University of California at San Francisco Audit (A-03-10-03120)" (PDF). June 2011. Archived (PDF) from the original on October 15, 2011. Retrieved June 25, 2011.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract N01-AI-3-0052 With Avecia Biologics Limited" (PDF). September 2011. Archived (PDF) from the original on October 15, 2011. Retrieved October 9, 2011.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract HHSN266-2006-00015C With NexBio, Inc" (PDF). September 2011. Archived (PDF) from the original on October 15, 2011. Retrieved October 9, 2011.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract HHSN272-2008-00013C with the EMMES Corporation (A-03-10-03115)" (PDF). October 2011. Archived (PDF) from the original on June 2, 2013. Retrieved September 11, 2011.
"Appropriations Funding for Eunice Kennedy Shriver National Institute of Child Health and Human Development Contract HHSN275-03-3345 With Westat, Inc. Audit (A-03-10-03106)" (PDF). October 2011. Archived (PDF) from the original on June 1, 2013. Retrieved November 20, 2011.
"Appropriations Funding for National Institute on Drug Abuse Contract HHSN271-2007-00009C with Charles River Laboratories, Inc. (A-03-10-03104)" (PDF). October 2011. Archived (PDF) from the original on June 2, 2013. Retrieved November 22, 2011.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract HHSN266-2005-00022C With PPD Development, LP (Audit A-03-10-03118)" (PDF). September 2012. Archived (PDF) from the original on May 22, 2013. Retrieved September 26, 2012.
"Appropriations Funding for National Institute of Allergy and Infectious Diseases Contract N01-AI-30068 With PPD Development, LP (Audit A-03-10-03116)" (PDF). September 2012. Archived (PDF) from the original on May 22, 2013. Retrieved September 26, 2011.
74. ^ Do a Google search for "NICHHD" (there are none) site:https://www.nichd.nih.gov/
75. ^ Pub.L. 117–103: Consolidated Appropriations Act, 2022 (text) (PDF)
76. ^ 87 FR 32174
77. ^ "Russell Named Acting Deputy Director for New Advanced Research Entity". NIH Record. June 10, 2022. Retrieved June 14, 2023.
78. ^ Mesa, Natalie (April 1, 2022). "ARPA-H to Be Within NIH but Independently Managed by HHS". The Scientist Magazine. Retrieved June 14, 2023.
79. ^ "Budget and Appropriations". ARPA-H. Retrieved June 14, 2023.
80. ^ Kozlov, Max (June 14, 2022). "Billion-dollar US health agency gets new chief — but its direction remains in limbo". Nature. Retrieved September 14, 2022.
81. ^ "The NIH Directors". National Institutes of Health. February 11, 2015. Archived from the original on June 1, 2013.

* This article incorporates public domain material from websites or documents of the National Institutes of Health.

## External links

[edit | edit source]

Wikimedia Commons has media related to National Institutes of Health.

* Official website
* National Institutes of Health in the Federal Register
* Regional Medical Programs Collection of information on NIH's Regional Medical Programs, from the National Library of Medicine

* v
* t
* e

U.S. National Institutes of Health (list)

Institutes|

* National Cancer Institute
* National Eye Institute
* National Heart, Lung, and Blood Institute
* National Human Genome Research Institute
* National Institute on Aging
* National Institute on Alcohol Abuse and Alcoholism
* National Institute of Allergy and Infectious Diseases
* National Institute of Arthritis and Musculoskeletal and Skin Diseases
* National Institute of Biomedical Imaging and Bioengineering
* National Institute of Child Health and Human Development
* National Institute on Deafness and Other Communication Disorders
* National Institute of Dental and Craniofacial Research
* National Institute of Diabetes and Digestive and Kidney Diseases
* National Institute on Drug Abuse
* National Institute of Environmental Health Sciences
* National Institute of General Medical Sciences
* National Institute of Mental Health
* National Institute on Minority Health and Health Disparities
* National Institute of Neurological Disorders and Stroke
* National Institute of Nursing Research
* National Library of Medicine

Centers|

* Center for Information Technology
* Center for Scientific Review
* John E. Fogarty International Center
* National Center for Complementary and Integrative Health
* National Center for Advancing Translational Sciences
* Vaccine Research Center
* National Institutes of Health Clinical Center

Programs|

* Advanced Research Projects Agency for Health
* Visible Human Project
* National Diabetes Education Program
* BRAIN Initiative

Directors|

* Joseph J. Kinyoun
* Milton J. Rosenau
* John F. Anderson
* George W. McCoy
* Lewis R. Thompson
* Rolla Dyer
* William H. Sebrell, Jr
* James Augustine Shannon
* Robert Q. Marston
* Robert Stone
* Donald S. Fredrickson
* James B. Wyngaarden
* Bernadine Healy
* Harold E. Varmus
* Elias Zerhouni
* Francis Collins
* Lawrence A. Tabak

Related|

* NIH Record
* United States Public Health Service
* Division of Intramural Research
* National Institutes of Health campus
* National Institutes of Health Director's Pioneer Award
* NIH Public Access Policy
* National Center for Research Resources
* National Institutes of Health Police
* Office of Laboratory Animal Welfare

Italics indicate acting officeholders

* v
* t
* e

United States Department of Health and Human Services

* Headquarters: Hubert H. Humphrey Building

* Xavier Becerra, Secretary of Health and Human Services
* Andrea Palm, Deputy Secretary of Health and Human Services

Secretariat staff offices|

* Office of the Secretary of Health and Human Services
* Office of the Deputy Secretary of Health and Human Services
* Office of Inspector General
* Office of the National Coordinator for Health Information Technology

Public Health Service|

* Office of the Assistant Secretary for Health
* Office of the Surgeon General
* Public Health Service Commissioned Corps
* Agency for Healthcare Research and Quality
* Agency for Toxic Substances and Disease Registry
* Centers for Disease Control and Prevention
* National Center for Injury Prevention and Control
* Food and Drug Administration
* Health Resources and Services Administration
* Indian Health Service
* National Institutes of Health
* Substance Abuse and Mental Health Services Administration
* Center for Behavioral Health Statistics and Quality

Human services agencies|

* Administration for Children and Families (Office of Refugee Resettlement)
* Administration for Community Living
* Administration on Aging
* Centers for Medicare & Medicaid Services

Programs|

* Child Welfare Information Gateway
* National Toxicology Program

* v
* t
* e

Federal research and development agencies of the United States (list)

Independent
agencies|

* National Science Foundation (NSF)
* National Aeronautics and Space Administration (NASA)
* Environmental Protection Agency Office of Research and Development
* Intelligence Advanced Research Projects Activity (IARPA)
* Smithsonian Institution research centers and programs

Agriculture|

* Agricultural Research Service (ARS)
* National Institute of Food and Agriculture (NIFA)
* Economic Research Service (ERS)
* United States Forest Service Research and Development (R&D)

Commerce|

* National Institute of Standards and Technology (NIST)
* National Oceanic and Atmospheric Administration (NOAA)

Defense|

| Army|

* Army Combat Capabilities Development Command (CCDCOM)
* Army Research Laboratory (ARL)
* Combat Capabilities Development Command Soldier Center (CCDCSC)
* CCDC Armaments Center (CCDCAC)
* Picatinny Arsenal
* Benét Laboratories
* Watervliet Arsenal
* Test and Evaluation Command (ATEC)
* United States Army Medical Research and Development Command (USAMRDC)
* Engineer Research and Development Center (ERDC)

|

Marine Corps|

* Marine Corps Combat Development Command (MCCDC)
* Marine Corps Warfighting Laboratory (MCWL)
* Marine Corps Operational Test and Evaluation Activity (MCOTEA)

Navy|

* Office of Naval Research (ONR)
* Naval Research Laboratory (NRL)
* Naval Medical Research Center (NMRC)
* Naval Warfare Centers
* Air (NAWC)
* Surface (NSWC)
* Undersea (NUWC)
* Command, Control and Ocean Surveillance (NCCOSC)
* Naval Air Weapons Station China Lake (NAWS)
* Naval Postgraduate School (NPS)
* Operational Test and Evaluation Force (OPTEVFOR)

Air Force|

* Air Force Materiel Command (AFMC)
* Air Armament Center (AAC)
* Air Force Research Laboratory (AFRL)
* Air Force Life Cycle Management Center (AFLCMC)
* Air Force Nuclear Weapons Center (NWC)
* Air Force Institute of Technology (AFIT)
* Air Force Operational Test and Evaluation Center (AFOTEC)

Space Force|

* Space Systems Command (SSC)

Other|

* Defense Advanced Research Projects Agency (DARPA)
* Uniformed Services University of the Health Sciences (USU)

Education|

* Institute of Education Sciences (IES)
* National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR)

Energy|

* Office of Science (DOE SC)
* Advanced Research Projects Agency–Energy (ARPA-E)
* National Laboratories

Health and
Human Services|

* National Institutes of Health (NIH)
* National Institute for Occupational Safety and Health (NIOSH)
* Food and Drug Administration science and research programs
* Agency for Healthcare Research and Quality (AHRQ)
* Biomedical Advanced Research and Development Authority (BARDA)
* Center for Medicare and Medicaid Innovation (CMMI)

Homeland Security|

* Science and Technology Directorate (S&T)
* Coast Guard Research and Development Center  (CG RDC)

Interior|

* United States Geological Survey (USGS)

Justice|

* National Institute of Justice (NIJ)
* FBI Science and Technology Branch

Transportation|

* Research and Innovative Technology Administration
* Federal Aviation Administration Research, Engineering, and Development
* Federal Highway Administration Research and Technology

Treasury|

* Office of Financial Research (OFR)

Veterans Affairs|

* Veterans Health Administration Office of Research and Development (ORD)

Executive Office
of the President|

* Office of Science and Technology Policy (OSTP)
* U.S. Global Change Research Program (USGCRP)
* Networking and Information Technology Research and Development Program (NITRD)
* National Nanotechnology Initiative (NNI)

Legislative branch|

* House Committee on Science, Space, and Technology
* Senate Committee on Commerce, Science, and Transportation
* Office of Technology Assessment (OTA) (defunct)

Judicial branch|

* Federal Judicial Center

* v
* t
* e

Montgomery County, Maryland

* Washington metropolitan area

Administration|

* Montgomery County Police Department
* Montgomery County Public Schools
* Montgomery County Fire and Rescue Service
* Montgomery County Sheriff's Office

Landmarks|

* National Institutes of Health
* Shady Grove Adventist Hospital
* Walter Reed National Military Medical Center
* White's Ferry

Culture|

* Flag of Montgomery County
* Maryland SoccerPlex
* BlackRock Center for the Arts

Sports|

* Washington Spirit
* Bethesda Big Train
* Rockville Express
* Silver Spring-Takoma Thunderbolts

Education|

| Colleges|

* Ana G. Méndez University Capital Area Campus
* Montgomery College
* Uniformed Services University of the Health Sciences
* Universities at Shady Grove
* Washington Adventist University

|

High schools|

* Bethesda-Chevy Chase
* Blair
* Blake
* Churchill
* Clarksburg
* Damascus
* Edison
* Einstein
* Gaithersburg
* Johnson
* Kennedy
* Magruder
* Northwest
* Northwood
* Paint Branch
* Poolesville
* Quince Orchard
* Richard Montgomery
* Rockville
* Seneca Valley
* Sherwood
* Springbrook
* Watkins Mill
* Wheaton
* Whitman
* Wootton

Private|

* Barrie School
* Brookewood School
* Cristo Rey
* Georgetown Prep
* Good Counsel
* The Avalon
* The Heights
* Holy Child
* Holy Cross
* Montrose Christian
* St. Andrew's
* Stone Ridge

Transportation|

| Air|

* Montgomery County Airpark

|

Public transportation|

* Metrobus
* Metrorail
* RideOn

Highways|

* Capital Beltway
* Inter-county Connector
* Interstate 270
* Interstate 370

Roads|

* Clopper Road
* Connecticut Avenue
* East-West Highway
* Georgia Avenue
* Germantown Road
* Great Seneca Highway
* New Hampshire Avenue
* Norbeck Road
* Old Georgetown Road
* Quince Orchard Road
* River Road
* Rockville Pike
* Sandy Spring Road
* University Boulevard
* Veirs Mill Road

* v
* t
* e

Hospitals in Maryland

General/Acute/Emergency|

* Adventist HealthCare - Fort Washington
* Adventist HealthCare - Shady Grove
* Adventist HealthCare - White Oak
* Anne Arundel Medical Center
* Atlantic General
* CalvertHealth
* Carroll Hospital
* Doctors Community
* Frederick Memorial
* Garrett Regional
* Grace Medical Center
* GBMC
* Holy Cross - Germantown
* Holy Cross - Silver Spring
* Howard County General
* Johns Hopkins
* Johns Hopkins Bayview
* MedStar Franklin Square
* MedStar Good Samaritan
* MedStar Harbor
* MedStar Montgomery
* MedStar Southern Maryland
* MedStar St. Mary's
* MedStar Union Memorial
* Mercy
* Meritus
* Northwest
* St. Agnes
* Sinai
* Suburban
* TidalHealth Peninsula Regional
* Union
* UPMC Western Maryland
* University of Maryland Medical Center (UMMC) (R Adams Cowley Shock Trauma Center)
* UMMC Midtown
* UM Baltimore Washington Medical Center
* UM Capital Region
* UM Charles Regional
* UM Harford Memorial
* UM Shore - Chestertown
* UM Shore - Easton
* UM St. Joseph
* UM Upper Chesapeake
* Walter Reed NMMC

Freestanding Emergency Centers|

* Adventist HealthCare - Germantown EC
* TidalHealth McCready Pavilion
* UM Bowie Health Center EC
* UM Laurel Medical Center
* UM Shore - Cambridge MC
* UM Shore - Queenstown EC

Long term/rehab/outpatient|

* Adventist Rehabilitation Hospital of Maryland
* Brandenburg Center
* Deer's Head Center
* Gladys Spellman Specialty Hospital & Nursing Center
* Holly Center
* Kennedy Krieger Institute
* UM Rehab & Ortho Institute
* Levindale Hebrew Geriatric Center and Hospital
* Mt. Washington Pediatric Hospital
* VA Baltimore
* VA Perry Point
* Western Maryland Hospital Center

Psychiatric|

* Adventist Behavioral Health Eastern Shore
* Adventist Behavioral Health Rockville
* Brook Lane
* Clifton T. Perkins
* Eastern Shore
* Saint Luke Institute
* Sheppard Pratt
* Sheppard Pratt at Elkridge
* Sheppard Pratt at Ellicott City
* Spring Grove
* Springfield
* Thomas B. Finan Center

Research/Teaching|

* Johns Hopkins Hospital
* Johns Hopkins Children's Center
* MedStar Union Memorial
* NIH
* St. Agnes Hospital
* University of Maryland Medical Center
* National Institutes of Health Clinical Center
* Walter Reed NMMC

Defunct|

* Baltimore General Dispensary
* Children's Hospital
* Church Home and Hospital
* Crownsville Hospital Center
* McCready Memorial
* Fallston General Hospital
* Forest Haven
* Fort Howard Veterans Hospital
* Glenn Dale Hospital
* Gundry Sanitarium
* Henryton State Hospital
* Jarvis Hospital
* Laurel Sanitarium
* Lutheran Hospital
* Memorial of Cumberland
* Pine Bluff State Hospital
* Provident Hospital
* Rosewood Center
* Sydenham
* Sacred Heart
* UM Shore - Dorchester
* UM Prince George's
* University Specialty Hospital
* Walter P Carter Center
* Washington County Hospital
* Women's Hospital

Italics denote designated Trauma Centers
*[Pub.L.]: Public Law (United States)
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template