ALPI

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Identifiers
Aliases|
External IDs| GeneCards: [1]
Orthologs
Species| Human| Mouse
Entrez| |

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Ensembl| |

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UniProt| |

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RefSeq (mRNA)| |

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RefSeq (protein)| |

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Location (UCSC)| n/a| n/a
PubMed search| n/a| n/a
Wikidata
| View/Edit Human|

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Alkaline phosphatase, intestinal also known as ALPI is a type of alkaline phosphatase that in humans is encoded by the ALPI gene.[1][2]

## References

[edit | edit source]

1. ↑ Berger J, Garattini E, Hua JC, Udenfriend S (February 1987). "Cloning and sequencing of human intestinal alkaline phosphatase cDNA". Proc. Natl. Acad. Sci. U.S.A. 84 (3): 695–8. doi:10.1073/pnas.84.3.695. PMC 304282. PMID 3468508.
2. ↑ Henthorn PS, Raducha M, Edwards YH, Weiss MJ, Slaughter C, Lafferty MA, Harris H (March 1987). "Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase". Proc. Natl. Acad. Sci. U.S.A. 84 (5): 1234–8. doi:10.1073/pnas.84.5.1234. PMC 304401. PMID 3469665.

## External links

[edit | edit source]

* Human ALPI genome location and ALPI gene details page in the UCSC Genome Browser.

## Further reading

[edit | edit source]

* Hirasaka K, Tokuoka K, Nakao R, et al. (2008). "Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells". J Physiol Sci. 58 (2): 105–11. doi:10.2170/physiolsci.RP013007. PMID 18307834.
* Mahmood A, Shao JS, Alpers DH (2003). "Rat enterocytes secrete SLPs containing alkaline phosphatase and cubilin in response to corn oil feeding". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2): G433–41. doi:10.1152/ajpgi.00466.2002. PMID 12660142.
* Wada A, Wang AP, Isomoto H, et al. (2005). "Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin". Int. J. Med. Microbiol. 294 (7): 427–35. doi:10.1016/j.ijmm.2004.09.012. PMID 15715171.
* Nakano T, Inoue I, Alpers DH, et al. (2009). "Role of lysophosphatidylcholine in brush-border intestinal alkaline phosphatase release and restoration". Am. J. Physiol. Gastrointest. Liver Physiol. 297 (1): G207–14. doi:10.1152/ajpgi.90590.2008. PMC 3817256. PMID 19407215.
* Malo MS, Zhang W, Alkhoury F, et al. (2004). "Thyroid hormone positively regulates the enterocyte differentiation marker intestinal alkaline phosphatase gene via an atypical response element". Mol. Endocrinol. 18 (8): 1941–62. doi:10.1210/me.2003-0351. PMID 15143152.
* Rump A, Kasper G, Hayes C, et al. (2001). "Complex arrangement of genes within a 220-kb region of double-duplicated DNA on human 2q37.1". Genomics. 73 (1): 50–5. doi:10.1006/geno.2000.6504. PMID 11352565.
* Nauli AM, Zheng S, Yang Q, et al. (2003). "Intestinal alkaline phosphatase release is not associated with chylomicron formation". Am. J. Physiol. Gastrointest. Liver Physiol. 284 (4): G583–7. doi:10.1152/ajpgi.00482.2002. PMID 12466148.
* Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
* Alkhoury F, Malo MS, Mozumder M, et al. (2005). "Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G285–90. doi:10.1152/ajpgi.00037.2005. PMID 15774940.
* Giatromanolaki A, Sivridis E, Maltezos E, Koukourakis MI (2002). "Down-regulation of intestinal-type alkaline phosphatase in the tumor vasculature and stroma provides a strong basis for explaining amifostine selectivity". Semin. Oncol. 29 (6 Suppl 19): 14–21. doi:10.1053/sonc.2002.37356. PMID 12577238.
* Torres MI, Lorite P, López-Casado MA, Ríos A (2007). "A new approach using tissue alkaline phosphatase histochemistry to identify Crohn's disease". Pathol. Res. Pract. 203 (6): 485–7. doi:10.1016/j.prp.2007.02.003. PMID 17498884.
* Hinnebusch BF, Siddique A, Henderson JW, et al. (2004). "Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Kruppel-like factor". Am. J. Physiol. Gastrointest. Liver Physiol. 286 (1): G23–30. doi:10.1152/ajpgi.00203.2003. PMID 12919939.
* Le Du MH, Millan JL (2002). "Structural evidence of functional divergence in human alkaline phosphatases". J. Biol. Chem. 277 (51): 49808–14. doi:10.1074/jbc.M207394200. PMID 12372831.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Goldberg RF, Austen WG, Zhang X, et al. (2008). "Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition". Proc. Natl. Acad. Sci. U.S.A. 105 (9): 3551–6. doi:10.1073/pnas.0712140105. PMC 2265168. PMID 18292227.
* Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
* Olsen L, Bressendorff S, Troelsen JT, Olsen J (2005). "Differentiation-dependent activation of the human intestinal alkaline phosphatase promoter by HNF-4 in intestinal cells". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (2): G220–6. doi:10.1152/ajpgi.00449.2004. PMID 15831710.
* Fumoto K, Hoogenraad CC, Kikuchi A (2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome". EMBO J. 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904. PMID 17139249.
* Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

* v
* t
* e

Hydrolase: esterases (EC 3.1)

3.1.1: Carboxylic
ester hydrolases|

* Cholinesterase
* Acetylcholinesterase
* Butyrylcholinesterase
* Pectinesterase
* 6-phosphogluconolactonase
* PAF acetylhydrolase

* Lipase
* Bile salt-dependent
* Gastric/Lingual
* Pancreatic
* Lysosomal
* Hormone-sensitive
* Endothelial
* Hepatic
* Lipoprotein
* Monoacylglycerol
* Diacylglycerol

* Phospholipase
* A1
* A2
* B

* Cutinase
* PETase

3.1.2: Thioesterase|

* Palmitoyl protein thioesterase
* Ubiquitin carboxy-terminal hydrolase L1
* 4-hydroxybenzoyl-CoA thioesterase

3.1.3: Phosphatase|

* Alkaline phosphatase
* ALPI
* ALPL
* ALPP
* Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
* Nucleotidase
* Glucose 6-phosphatase
* Fructose 1,6-bisphosphatase
* Calcineurin
* Protein phosphatase
* PP2A
* OCRL
* Pyruvate dehydrogenase phosphatase
* Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
* PTEN
* Phytase
* Beta-propeller phytase
* Inositol-phosphate phosphatase
* IMPA1, IMPA2, IMPA3
* Protein phosphatase: Protein tyrosine phosphatase
* Protein serine/threonine phosphatase
* Dual-specificity phosphatase

3.1.4:
Phosphodiesterase|

* Autotaxin
* Phospholipase
* C
* D
* Sphingomyelin phosphodiesterase
* 1
* PDE1
* PDE2
* PDE3
* PDE4A/PDE4B
* PDE5
* Lecithinase (Clostridium perfringens alpha toxin)
* Cyclic nucleotide phosphodiesterase

3.1.6: Sulfatase|

* arylsulfatase
* Arylsulfatase A
* Arylsulfatase B
* Arylsulfatase E
* Steroid sulfatase
* Galactosamine-6 sulfatase
* Iduronate-2-sulfatase
* N-acetylglucosamine-6-sulfatase

Nuclease (includes
deoxyribonuclease
and ribonuclease)|

| 3.1.11-16:
Exonuclease|

| Exodeoxyribonuclease|

* RecBCD

|

Exoribonuclease|

* Oligonucleotidase

3.1.21-31:
Endonuclease|

| Endodeoxyribonuclease|

* Deoxyribonuclease I
* Deoxyribonuclease II
* Deoxyribonuclease IV
* Restriction enzyme
* UvrABC endonuclease

|

Endoribonuclease|

* RNase III
* RNase H
* 1
* 2A
* 2B
* 2C
* RNase P
* RNase A
* 1
* 2
* 3
* 4/5
* RNase T1
* RNA-induced silencing complex

either deoxy- or ribo-|

* Aspergillus nuclease S1
* Micrococcal nuclease

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