Adhesin

WikiDoc Resources for Adhesin

Articles

Most recent articles on Adhesin

Most cited articles on Adhesin

Review articles on Adhesin

Articles on Adhesin in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Adhesin

Images of Adhesin

Photos of Adhesin

Podcasts & MP3s on Adhesin

Videos on Adhesin

Evidence Based Medicine

Cochrane Collaboration on Adhesin

Bandolier on Adhesin

TRIP on Adhesin

Clinical Trials

Ongoing Trials on Adhesin at Clinical Trials.gov

Trial results on Adhesin

Clinical Trials on Adhesin at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Adhesin

NICE Guidance on Adhesin

NHS PRODIGY Guidance

FDA on Adhesin

CDC on Adhesin

Books

Books on Adhesin

News

Adhesin in the news

Be alerted to news on Adhesin

News trends on Adhesin

Commentary

Blogs on Adhesin

Definitions

Definitions of Adhesin

Patient Resources / Community

Patient resources on Adhesin

Discussion groups on Adhesin

Patient Handouts on Adhesin

Directions to Hospitals Treating Adhesin

Risk calculators and risk factors for Adhesin

Healthcare Provider Resources

Symptoms of Adhesin

Causes & Risk Factors for Adhesin

Diagnostic studies for Adhesin

Treatment of Adhesin

Continuing Medical Education (CME)

CME Programs on Adhesin

International

Adhesin en Espanol

Adhesin en Francais

Business

Adhesin in the Marketplace

Patents on Adhesin

Experimental / Informatics

List of terms related to Adhesin

Adherence is often an essential step in bacterial pathogenesis or infection, required for colonizing a new host.[1] To effectively adhere to host surfaces, many bacteria produce multiple adherence factors called adhesins. For example, nontypeable Haemophilus influenzae expresses the adhesins Hia, Hap, Oap and a hemagglutinating pili.

Adhesins are attractive vaccine candidates because they are often essential to infection and are surface-located, making them readily accessible to antibodies.

The effectiveness of anti-adhesin antibodies is illustrated by studies with FimH, the adhesin of uropathogenic Escherichia coli (UPEC). In animal models, passive immunization with anti FimH-antibodies and vaccination with the protein significantly reduced colonization by UPEC.[2] Moreover, the Bordetella pertussis adhesins FHA and pertactin are components of 3 of the 4 acellular pertussis vaccines currently licensed for use in the U.S.

## References

[edit | edit source]

1. ↑ Coutte L, Alonso S, Reveneau N, Willery E, Quatannens B, Locht C, Jacob-Dubuisson F (2003). "Role of adhesin release for mucosal colonization by a bacterial pathogen". J Exp Med. 197 (6): 735–42. PMID 12629063.CS1 maint: Multiple names: authors list (link)
2. ↑ Langermann S, Möllby R, Burlein J, Palaszynski S, Auguste C, DeFusco A, Strouse R, Schenerman M, Hultgren S, Pinkner J, Winberg J, Guldevall L, Söderhäll M, Ishikawa K, Normark S, Koenig S (2000). "Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli". J Infect Dis. 181 (2): 774–8. PMID 10669375.CS1 maint: Multiple names: authors list (link)

Template:WH Template:WS