Afamin

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Identifiers
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External IDs| GeneCards: [1]
Orthologs
Species| Human| Mouse
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Wikidata
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Afamin is a protein that in humans is encoded by the AFM gene.[1][2]

## Contents

* 1 Function
* 2 References
* 3 External links
* 4 Further reading

## Function

[edit | edit source]

This gene is a member of the albumin gene family, which comprises four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.[2]

## References

[edit | edit source]

1. ↑ Lichenstein HS, Lyons DE, Wurfel MM, Johnson DA, McGinley MD, Leidli JC, Trollinger DB, Mayer JP, Wright SD, Zukowski MM (Aug 1994). "Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family". J Biol Chem. 269 (27): 18149–54. PMID 7517938.
2. ↑ 2.0 2.1 "Entrez Gene: AFM afamin".

## External links

[edit | edit source]

* Human AFM genome location and AFM gene details page in the UCSC Genome Browser.

## Further reading

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* Noppe M, Lowenthal A, Karcher D, Gheuens J (1979). "A two-site immunoradiometric assay for the determination of alpha-albumin". J. Immunol. Methods. 27 (1): 75–81. doi:10.1016/0022-1759(79)90240-0. PMID 37276.
* Hansson E, Rönnbäck L, Lowenthal A, Noppe M (1985). "Primary cultures from defined brain areas; effects of seeding time on cell growth, astroglial content and protein synthesis". Brain Res. 353 (2): 175–85. doi:10.1016/0165-3806(85)90206-8. PMID 4041902.
* Lowenthal A, Flament-Durand J, Karcher D, Noppe M, Brion JP (1982). "Glial cells identified by anti-alpha-albumin (anti-GFA) in human pineal gland". J. Neurochem. 38 (3): 863–5. doi:10.1111/j.1471-4159.1982.tb08714.x. PMID 7035619.
* Allard D, Gilbert S, Lamontagne A, Hamel D, Bélanger L (1995). "Identification of rat alpha-albumin and cDNA cloning of its human ortholog". Gene. 153 (2): 287–8. doi:10.1016/0378-1119(94)00745-E. PMID 7875606.
* Nishio H, Heiskanen M, Palotie A, Bélanger L, Dugaiczyk A (1996). "Tandem arrangement of the human serum albumin multigene family in the sub-centromeric region of 4q: evolution and chromosomal direction of transcription". J. Mol. Biol. 259 (1): 113–9. doi:10.1006/jmbi.1996.0306. PMID 8648639.
* Nishio H, Dugaiczyk A (1996). "Complete structure of the human alpha-albumin gene, a new member of the serum albumin multigene family". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7557–61. doi:10.1073/pnas.93.15.7557. PMC 38784. PMID 8755513.
* Song YH, Naumova AK, Liebhaber SA, Cooke NE (1999). "Physical and meiotic mapping of the region of human chromosome 4q11-q13 encompassing the vitamin D binding protein DBP/Gc-globulin and albumin multigene cluster". Genome Res. 9 (6): 581–7. doi:10.1101/gr.9.6.581. PMC 310762. PMID 10400926.
* Khan MA, Kumar Y, Tayyab S (2003). "Bilirubin binding properties of pigeon serum albumin and its comparison with human serum albumin". Int. J. Biol. Macromol. 30 (3–4): 171–8. doi:10.1016/S0141-8130(02)00017-X. PMID 12063119.
* Voegele AF, Jerković L, Wellenzohn B, Eller P, Kronenberg F, Liedl KR, Dieplinger H (2003). "Characterization of the vitamin E-binding properties of human plasma afamin". Biochemistry. 41 (49): 14532–8. doi:10.1021/bi026513v. PMID 12463752.
* Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wiśniewski JR (2004). "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry". Proteomics. 4 (2): 454–65. doi:10.1002/pmic.200300556. PMID 14760718.
* Jerkovic L, Voegele AF, Chwatal S, Kronenberg F, Radcliffe CM, Wormald MR, Lobentanz EM, Ezeh B, Eller P, Dejori N, Dieplinger B, Lottspeich F, Sattler W, Uhr M, Mechtler K, Dwek RA, Rudd PM, Baier G, Dieplinger H (2005). "Afamin is a novel human vitamin E-binding glycoprotein characterization and in vitro expression". J. Proteome Res. 4 (3): 889–99. doi:10.1021/pr0500105. PMID 15952736.
* Hu Y, Malone JP, Fagan AM, Townsend RR, Holtzman DM (2006). "Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid". Mol. Cell. Proteomics. 4 (12): 2000–9. doi:10.1074/mcp.M500207-MCP200. PMID 16199891.
* Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
* Ramachandran P, Boontheung P, Xie Y, Sondej M, Wong DT, Loo JA (2006). "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry". J. Proteome Res. 5 (6): 1493–503. doi:10.1021/pr050492k. PMID 16740002.

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