Alpha blocker

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Contents

* 1 Overview
* 2 Indications
* 3 Examples of alpha blockers
* 4 Adverse effects and interactions
* 5 References

## Overview[edit | edit source]

Alpha blockers (also called alpha-adrenergic blocking agents) constitute a variety of drugs which block α1-adrenergic receptors in arteries and smooth muscles.

## Indications[edit | edit source]

These drugs may be used to treat:

* benign prostatic hyperplasia (BPH)
* high blood pressure (hypertension). This is not typically the drug of choice unless the patient also has BPH.
* symptoms of non inflammatory chronic pelvic pain syndrome, a type of prostatitis. As a side effect they may reduce blood pressure and result in lightheadedness.

## Examples of alpha blockers[edit | edit source]

Alpha blockers include:

* Doxazosin (Cardura)
* Prazosin (Minipress)
* Phenoxybenzamine
* Phentolamine (Regitine)
* Tamsulosin (Flomaxtra/Flomax)
* Alfuzosin (Uroxatral)
* Terazosin (Hytrin)

Tamsulosin is relatively selective for α1a-adrenergic receptors, which are mainly present in the prostate. Hence, it may have a more selective action in BPH with minimal effects on blood pressure.

## Adverse effects and interactions[edit | edit source]

By reducing α1-adrenergic activity of the blood vessels, these drugs may cause hypotension (low blood pressure) and interrupt the baroreflex response. In doing so, they may cause dizziness, lightheadedness, or fainting when rising from a lying or sitting posture (known as orthostatic hypotension or postural hypotension). For this reason, it is generally recommended that alpha blockers should be taken at bedtime. Additionally, the risk of orthostatic hypotension may be reduced by starting at a low dose and titrating upwards as needed.

Because these medications may cause orthostatic hypotension, as well as hypotension in general, these agents may interact with other medications that increase risk for hypotension, such as other antihypertensives and vasodilators.

As discussed above, tamsulosin may have less risk for hypotension and orthostatic hypotension due to its selectivity for α1a-adrenergic receptors. On the other hand, the drug:

(a) elevates risk for floppy iris syndrome,

(b) might show ADRs characteristic of the sulfa related drugs.

## References[edit | edit source]

* DrugDigest \- Alpha blockers
* RxList.com \- Tamsulosin
* alpha-Adrenergic+Blockers at the US National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Antihypertensives (C02) and diuretics (C03)

Sympatholytic agents|

Template:Navbox subgroup

Vasodilators|

Diazoxide • hydrazinophthalazine (Hydralazine, Dihydralazine, Endralazine, Cadralazine) • Minoxidil • Nitroprusside • Phentolamine

Other antihypertensives|

serotonin antagonist (Ketanserin) • endothelin receptor antagonist (Bosentan, Ambrisentan, Sitaxsentan) • MAOI (Pargyline) • THI (Metirosine)

Diuretics|

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* v
* t
* e

Urologicals (G04)

Acidifiers|

Ammonium chloride, Calcium chloride

Urinary antispasmodics (primarily antimuscarinics)|

Darifenacin, Emepronium, Fesoterodine, Flavoxate, Meladrazine, Oxybutynin, Propiverine, Solifenacin, Terodiline, Tolterodine, Trospium

For erectile dysfunction|

prostaglandins: Alprostadil

PDE5 inhibitors: Avanafil \- Sildenafil \- Tadalafil \- Udenafil \- Vardenafil

alpha blockers: Moxisylyte \- Phentolamine \- Yohimbine

others: Apomorphine \- Papaverine

Other urologicals|

Acetohydroxamic acid, Collagen, Dimethyl sulfoxide, Magnesium hydroxide, Pentosan polysulfate, Phenazopyridine, Phenyl salicylate, Succinimide

For benign prostatic hypertrophy|

5α-reductase inhibitors: Dutasteride, Finasteride

Alpha blockers: Alfuzosin, Doxazosin, Silodosin, Tamsulosin, Terazosin

Herbals: Pygeum africanum, Serenoa repens

Template:Receptor agonists and antagonists

de:Alphablocker it:Alfa bloccante

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