Amenorrhea diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Eiman Ghaffarpasand, M.D. [2]

## Overview

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There is no established criteria for the diagnosis of amenorrhea. However, the diagnosis of amenorrhea is based on delayed or absent menstrual cycle.

## Diagnostic Criteria

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* There is no established criteria for the diagnosis of amenorrhea.

* However, the diagnosis of amenorrhea is based on delayed or absent menstrual cycle.

### Primary amenorrhea

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* Absence of menarche until 15 years of age, in the presence of other secondary sexual characteristics.
* Absence of menarche after 5 years of thelarche, if thelarche occurred before 10 years of age.[1]

### Secondary amenorrhea

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* Menstrual cycle is interrupted for at least 3 months, however were regular before.[2]
* Menstrual cycle is interrupted for at least 6 months, however were irregular before.[3]

### Functional (hypothalamic) amenorrhea

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* The patient usually reports normal regular cycles in the past, with sudden interruption in menstrual cycles for more than 3 months.
* There is almost always a history of weight loss (severe), excessive exercise, or drastic emotional stress prior to cessation of menstruation.[4]

## References

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1. ↑ Herman-Giddens, M. E.; Slora, E. J.; Wasserman, R. C.; Bourdony, C. J.; Bhapkar, M. V.; Koch, G. G.; Hasemeier, C. M. (1997). "Secondary Sexual Characteristics and Menses in Young Girls Seen in Office Practice: A Study from the Pediatric Research in Office Settings Network". PEDIATRICS. 99 (4): 505–512. doi:10.1542/peds.99.4.505. ISSN 0031-4005.
2. ↑ Chiavaroli, Valentina; DAdamo, Ebe; Diesse, Laura; de, Tommaso; Chiarelli, Francesco; Moh, Angelika (2011). "Primary and Secondary Amenorrhea". doi:10.5772/17675.
3. ↑ Fritz, Marc (2011). Clinical gynecologic endocrinology and infertility. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ISBN 978-0781779685.
4. ↑ Meczekalski B, Katulski K, Czyzyk A, Podfigurna-Stopa A, Maciejewska-Jeske M (2014) Functional hypothalamic amenorrhea and its influence on women's health. J Endocrinol Invest 37 (11):1049-56. DOI:10.1007/s40618-014-0169-3 PMID: 25201001

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