Ankylosing spondylitis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief:  Manpreet Kaur, MD [2]

## Overview

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Ankylosing spondylitis is an inflammatory disease that in overtime it causes some of the vertebrae in your spine to fuse.Because of the fusion the spine less flexible and the patients present with hunched-forward posture. It can be difficult to breathe deeply when the ribs are involved.The most common cause of ankylosing spondylitis is involvement of gene HLA B27.

## Causes

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Common Causes

* Heredity
* People who are positive for HLA-B27 gene are more prone to develop ankylosing spondylitis.[1][2]
* Sex
* When compared to women, men are more likely to develop ankylosing spondylitis.
* Age
* Most commonly seen in adolescence.[3]
* Race
* Ankylosing spondylitis is more common in Native American tribes.[4]

## References

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1. ↑ Reveille JD, Hirsch R, Dillon CF, Carroll MD, Weisman MH (May 2012). "The prevalence of HLA-B27 in the US: data from the US National Health and Nutrition Examination Survey, 2009". Arthritis Rheum. 64 (5): 1407–11. doi:10.1002/art.33503. PMC 4038331. PMID 22139851.
2. ↑ Reveille JD (July 2006). "The genetic basis of ankylosing spondylitis". Curr Opin Rheumatol. 18 (4): 332–41. doi:10.1097/01.bor.0000231899.81677.04. PMID 16763451.
3. ↑ Reveille JD, Weisman MH (June 2013). "The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States". Am. J. Med. Sci. 345 (6): 431–6. PMC 4122314. PMID 23841117.
4. ↑ Reveille JD (April 2011). "Epidemiology of spondyloarthritis in North America". Am. J. Med. Sci. 341 (4): 284–6. doi:10.1097/MAJ.0b013e31820f8c99. PMC 3063892. PMID 21430444.

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