Ankylosing spondylitis historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:  Manpreet Kaur, MD [2]

## Overview

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Galen was the first to distinguish the difference between ankylosing spondylitis and rheumatoid arthritis.Realdo Colombo has first described ankylosing spondylitis.Bernard Connor was first to describe ankylosing spondylitis pathologic changes.

## Historical Perspective

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* In 2nd century, Galen was the first to distinguish the difference between ankylosing spondylitis and rheumatoid arthritis.[1]
* A 5000-year-old Egyptian mummy skeletal remains shows skeletal evidence of the disease ankylosing spondylitis.[2]
* Ankylosing spondylitis was first described by Realdo Colombo,a anatomist and surgeon, in in 1559.[3]
* Ankylosing spondylitis pathologic changes was first described by Bernard Connor,in 1691.

## Landmark Events in the Development of Treatment Strategies

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* Monoclonal antibodies was developed to treat ankylosing spondylitis was an important landmark events in the treatment strategies.[4]

## References

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1. ↑ Dieppe P (January 1988). "Did Galen describe rheumatoid arthritis?". Ann. Rheum. Dis. 47 (1): 84–5. PMC 1003452. PMID 3278697.
2. ↑ Saleem SN, Hawass Z (December 2014). "Ankylosing spondylitis or diffuse idiopathic skeletal hyperostosis in royal Egyptian mummies of 18th -20th Dynasties? CT and archaeology studies". Arthritis Rheumatol. 66 (12): 3311–6. doi:10.1002/art.38864. PMID 25329920.
3. ↑ Benoist M (April 1995). "Pierre Marie. Pioneer investigator in ankylosing spondylitis". Spine. 20 (7): 849–52. PMID 7701402.
4. ↑ Sieper J (2009). "Developments in the scientific and clinical understanding of the spondyloarthritides". Arthritis Res. Ther. 11 (1): 208. doi:10.1186/ar2562. PMC 2688219. PMID 19232062.

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