Ankylosing spondylitis laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] : Associate Editor(s)-in-Chief:  Manpreet Kaur, MD [2]

## Overview

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There are no specific diagnostic laboratory findings associated with ankylosing spondylitis (AS). There are certain blood tests that can check for markers of inflammation.Most of the time patients with AS their blood is tested for the HLA-B27 gene, but again most people who are positive for that gene don't have ankylosing spondylitis. Other laboratory findings consistent with ankylosing spondylitis (AS) include ESR and CRP levels.

## Laboratory Findings[1][2][3]

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* There are no specific diagnostic laboratory findings associated with ankylosing spondylitis(AS) and most the tests are non-specific.
* Human leukocyte antigen (HLA)-B27 is positive in most the patients, but not invariably so.[4]
* laboratory findings consistent with ankylosing spondylitis(AS) include ESR and CRP levels.[5]
* Some patients with active AS are positive for normochromic normocytic anemia.
* Some patients with active AS are found to have increased levels of bone-specific alkaline phosphatase.[6][7]
* In some patients with AS serum levels of immunoglobulin A (IgA) are elevated.
* Elevated white blood cell count mainly polymorphonuclear leukocytes.

## References

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1. ↑ Rudwaleit M, van der Heijde D, Khan MA, Braun J, Sieper J (May 2004). "How to diagnose axial spondyloarthritis early". Ann. Rheum. Dis. 63 (5): 535–43. doi:10.1136/ard.2003.011247. PMC 1754994. PMID 15082484.
2. ↑ Sieper J, Braun J, Rudwaleit M, Boonen A, Zink A (December 2002). "Ankylosing spondylitis: an overview". Ann. Rheum. Dis. 61 Suppl 3: iii8–18. PMC 1766729. PMID 12381506.
3. ↑ Poddubnyy D, Haibel H, Listing J, Märker-Hermann E, Zeidler H, Braun J, Sieper J, Rudwaleit M (May 2012). "Baseline radiographic damage, elevated acute-phase reactant levels, and cigarette smoking status predict spinal radiographic progression in early axial spondylarthritis". Arthritis Rheum. 64 (5): 1388–98. doi:10.1002/art.33465. PMID 22127957.
4. ↑ de Winter JJ, van Mens LJ, van der Heijde D, Landewé R, Baeten DL (September 2016). "Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis". Arthritis Res. Ther. 18: 196. doi:10.1186/s13075-016-1093-z. PMC 5009714. PMID 27586785.
5. ↑ Rudwaleit M, Haibel H, Baraliakos X, Listing J, Märker-Hermann E, Zeidler H, Braun J, Sieper J (March 2009). "The early disease stage in axial spondylarthritis: results from the German Spondyloarthritis Inception Cohort". Arthritis Rheum. 60 (3): 717–27. doi:10.1002/art.24483. PMID 19248087.
6. ↑ Kang KY, Hong YS, Park SH, Ju JH (October 2015). "Increased serum alkaline phosphatase levels correlate with high disease activity and low bone mineral density in patients with axial spondyloarthritis". Semin. Arthritis Rheum. 45 (2): 202–7. doi:10.1016/j.semarthrit.2015.03.002. PMID 25895696.
7. ↑ Maksymowych WP (2009). "What do biomarkers tell us about the pathogenesis of ankylosing spondylitis?". Arthritis Res. Ther. 11 (1): 101. doi:10.1186/ar2565. PMC 2688221. PMID 19183433.

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