Anorectic

WikiDoc Resources for Anorectic

Articles

Most recent articles on Anorectic

Most cited articles on Anorectic

Review articles on Anorectic

Articles on Anorectic in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Anorectic

Images of Anorectic

Photos of Anorectic

Podcasts & MP3s on Anorectic

Videos on Anorectic

Evidence Based Medicine

Cochrane Collaboration on Anorectic

Bandolier on Anorectic

TRIP on Anorectic

Clinical Trials

Ongoing Trials on Anorectic at Clinical Trials.gov

Trial results on Anorectic

Clinical Trials on Anorectic at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Anorectic

NICE Guidance on Anorectic

NHS PRODIGY Guidance

FDA on Anorectic

CDC on Anorectic

Books

Books on Anorectic

News

Anorectic in the news

Be alerted to news on Anorectic

News trends on Anorectic

Commentary

Blogs on Anorectic

Definitions

Definitions of Anorectic

Patient Resources / Community

Patient resources on Anorectic

Discussion groups on Anorectic

Patient Handouts on Anorectic

Directions to Hospitals Treating Anorectic

Risk calculators and risk factors for Anorectic

Healthcare Provider Resources

Symptoms of Anorectic

Causes & Risk Factors for Anorectic

Diagnostic studies for Anorectic

Treatment of Anorectic

Continuing Medical Education (CME)

CME Programs on Anorectic

International

Anorectic en Espanol

Anorectic en Francais

Business

Anorectic in the Marketplace

Patents on Anorectic

Experimental / Informatics

List of terms related to Anorectic

Note: "Anorectic" is also a term for an anorexic person; a person suffering from Anorexia nervosa

## Contents

* 1 Overview
* 2 History and initial uses
* 3 Public health concerns
* 4 Currently marketed appetite suppressants
* 5 See also
* 6 References
* 7 External links

## Overview

[edit | edit source]

Anorectics, anorexigenics or appetite suppressants are drugs that reduce the appetite ("anorectic", from the Greek an\- = "not" and oreg\- = "extend, reach").

## History and initial uses

[edit | edit source]

Used on a short term basis clinically to treat obesity, some appetite suppressants are also available over the counter. Drugs of this class are frequently stimulants of the phenethylamine family, related to amphetamine (speed).

The German military experimented with issuing amphetamines to soldiers in 1945, when food supplies were very short in Germany. Following the Second World War, amphetamines were re-directed for use on the civilian market. Indeed, amphetamine itself was sold commercially as an appetite suppressant until it was outlawed in most parts of the world in the late 1950s due to increased recreational use. Many amphetamines produce side effects including addiction, tachycardia and hypertension, [1]making prolonged unsupervised use dangerous.

Many people who obtain these drugs are more interested in the amphetamine-like stimulant effects than weight loss. In those cases, it is important to make sure to keep forcing oneself to eat even when it is undesirable.

## Public health concerns

[edit | edit source]

Epidemics of fatal pulmonary hypertension and heart valve damage associated with anorectic agents have led to the withdrawal of products from the market. This was the case with aminorex in the 1960s, and again in the 1990s with fenfluramine (see: Fen-phen).[2] Likewise, association of the related appetite suppressant phenylpropanolamine with hemorrhagic stroke led the Food and Drug Administration (FDA) to request its withdrawal from the market in the United States in 2000, and similar concerns regarding ephedrine resulted in an FDA ban on its inclusion in dietary supplements, in 2004 (a Federal judge later overturned this ban in 2005 during a challenge by supplement maker Nutraceuticals.)

## Currently marketed appetite suppressants

[edit | edit source]

In spite of these precedents, numerous compounds are marketed today as appetite suppressants.

The following are listed as "centrally acting antiobesity preparations" by ATC:[3]

* Phentermine (Fastin®, Adipex®, Ionamin® and others)
* Diethylpropion (Tenuate®)
* Sibutramine (Meridia®, Reductil®)
* Rimonabant (Acomplia®)

The following are listed as appetite depressants by MeSH.[4]

* benfluorex
* butenolide
* diethylpropion
* FG 7142
* norpseudoephedrine
* phenmetrazine
* phentermine
* phenylpropanolamine
* pyroglutamyl-histidyl-glycine
* sibutramine

Other compounds marked as appetite suppressants include:

* Phendimetrazine (Prelu-2®, Bontril®)
* Benzphetamine (Didrex®)
* Oxyntomodulin
* Methylphenidate (Concerta) (Ritalin®)
* Phenylethylamine (Trimspa®)

## See also

[edit | edit source]

* Appetite
* Amphetamine
* Addiction
* Cocaine
* Obesity
* Stimulant
* Phenethylamine
* Aminorex
* Fen-phen
* Ephedrine
* Food and Drug Administration

## References

[edit | edit source]

1. ↑ Abenhaim L, Moride Y, Brenot F, Rich S, Benichou J, Kurz X, Higenbottam T, Oakley C, Wouters E, Aubier M, Simonneau G, Begaud B. Appetite-Suppressant Drugs and the Risk of Primary Pulmonary Hypertension. N Engl J Med 1996;335:609. Fulltext. PMID 8692238
2. ↑ Fishman AP. Aminorex to Fen/Phen: An Epidemic Foretold. Circulation 1999;99:156. Fulltext. PMID 9884392
3. ↑ http://www.whocc.no/atcddd/indexdatabase/index.php?query=A08AA
4. ↑ Template:MeshPharmaList

## External links

[edit | edit source]

* Questions and Answers about appetite suppressant medication treatment from the Medical College of Wisconsin
* Anorectics at the US National Library of Medicine Medical Subject Headings (MeSH)

Template:WS Template:Jb1

bs:Anoreksici de:Anorektikum hr:Anoreksici