Arthritis causes

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Differentrial Diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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## Causes

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### Common Causes

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* Osteoarthritis
* Rheumatoid arthritis
* Lupus erythematosus
* Henoch-Schönlein purpura
* Psoriatic arthritis
* Reactive arthritis
* Haemochromatosis
* Hepatitis
* Wegener's granulomatosis (and many other vasculitis syndromes)
* Lyme disease
* Familial Mediterranean fever
* Hyperimmunoglobulinemia D with recurrent fever
* TNF receptor associated periodic syndrome
* Inflammatory bowel disease (Including Crohn's Disease and Ulcerative Colitis)

### Causes by Organ System

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Cardiovascular | Dressler syndrome , Rheumatic Fever

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Chemical/Poisoning | No underlying causes
Dental | No underlying causes
Dermatologic | Erythema Nodosum, Familial cold urticaria, Lipoid dermatoarthritis , Psoriatic arthritis , Pyoderma gangrenosum
Drug Side Effect | Amphotericin B , Bismuth , Carbimazole , Ciprofloxacin ,Cefaclor, Dabrafenib , Deferiprone , Doxycycline , Drug-induced systemic lupus erythematosus, Febuxostat, Interleukin 2 , Isotretinoin , Letrozole, Methimazole , Methylphenidate , Mianserin, Minocycline hydrochloride, Nalidixic acid , Nateglinide, Nilutamide, Norfloxacin , Pembrolizumab, Penicillamine, Pergolide, Propylthiouracil , Pyrazinamide , Rasagiline , Thalidomide, Tiagabine, Tocilizumab, Toremifene, Trastuzumab, Travoprost, Zotepine
Ear Nose Throat | No underlying causes
Endocrine | Acromegaly , Diabetes Mellitus
Environmental | Frostbite
Gastroenterologic | celiac (sprue) disease , Crohn's Disease , Enteropathic arthritis , Hemarthrosis , Pancreatic carcinoma , Pancreatitis , ulcerative colitis , Whipple’s disease , Wilson disease
Genetic | Alpha-L-iduronidase deficiency (Hurler-Scheie syndrome) , [Alpha-L-iduronidase deficiency (Scheie syndrome)
Hematologic | Haemophilia type A , Hemoglobinopathies , Hyperglobulinemic Purpura , Hyperimmunoglobulinemia D and periodic fever syndrome ,

Hypogammaglobulinemia , Leukemia , Lymphoma , Multiple Myeloma , Sickle cell disease , Von Willenbrand's Disease

Iatrogenic | Graft versus host disease , intestinal bypass surgery , Renal dialysis
Infectious Disease | Acute viral polyarthritis , Adenoviruses  , Alphaviruses , Arboviruses , Bacterial Endocarditis , Borrelia burgdorferi , Chikungunya virus , Cytomegalovirus , Dengue virus , Echovirus , Enterobacteriaceae , Coxsackie Virus  ,Epstein-Barr viral syndrome, Escherichia coli, Fungal infection, Gonococcus, Gram-Negative Bacilli, Haemophilus influenzae, Hepatitis A, Hepatitis B , Hepatitis C , Herpes simplex virus , HIV , Infectious arthritis , Influenza (flu) , Lepromatous leprosy , Lyme disease , Mayaro virus fever , Measles  , Mumps , Mycoplasma pneumoniae , Neisseria gonorrhoeae , Osteomyelitis  , Parasitic infection , Parvovirus B19-associated arthritis , Pneumococcus , Queensland tick typhus , Rickettsial infection , Ross River virus , Rubella virus infection  , Secondary syphilis , Sindbis virus , Staphylococcus , Streptobacillary rat bite fever , Streptococcus , Tuberculosis , Varicella Zoster Virus , West Nile fever
Musculoskeletal/Orthopedic | Chondrosarcoma  , Dermatomyositis , Diffuse idiopathic skeletal hyperostosis
Neurologic | Syringomyelia , Systemic sclerosis , Tabes Dorsalis
Nutritional/Metabolic | Alkaptonuria , Calcium oxalate , Fabry's Disease , Gaucher's Disease , Glycogenosis type 1a , Haemochromatosis , Hyperlipoproteinemia , Storage Disease
Obstetric/Gynecologic | No underlying causes
Oncologic | Metastatic disease , Osteoid osteoma , Paraneoplastic disease , Pigmented villonodular synovitis  , Sarcoma
Ophthalmologic | No underlying causes
Overdose/Toxicity | No underlying causes
Psychiatric | No underlying causes
Pulmonary | Cystic fibrosis , Hypertrophic pulmonary osteo-arthropathy
Renal/Electrolyte | Renal dialysis , Renal transplant
Rheumatology/Immunology/Allergy | Kawasaki disease , Microscopic polyangiitis , Polyarteritis nodosa , Takayasu arteritis
Sexual | No underlying causes
Trauma | Injury , Fracture , Meniscal tear
Urologic | No underlying causes
Miscellaneous | Amyloidosis , Antisynthetase syndrome , Blau syndrome , Bonnet-Dechaume-Blanc syndrome , Bruton agammaglobulinemia , Caplan disease , CINCA syndrome , Craniomandibular dermatodysostosis , Erysipeloid of Rosenbach , Erythema elevatum diutinum , Familial Mediterranean Fever , Farber lipogranulomatosis , Foreign body , Hemangioma , Hunter-Thompson acromesomelic dysplasia , Intermittent hydrarthrosis , Jacobs arthropathy-camptodactyly syndrome , Metatropic dwarfism type 1 , Moore-Federman syndrome , Muckle-Wells syndrome , Mucolipidosis III alpha/beta , Mucopolysaccharidosis IX , Multicentric reticulohistiocytosis , Myhre syndrome , Palifermin , PAPA syndrome , Pegloticase , Progressive pseudorheumatoid dysplasia , Pseudoachondroplasia , Radiation , Recurrent hereditary polyserositis , Rhizomelic pseudopolyarthritis , SAPHO syndrome , Semliki forest fever , Sitosterolemia , Spondyloepiphyseal dysplasia tarda , X-linked , Stickler syndrome , Sweet syndrome , Tesamorelin , Tietze's Syndrome , Torg-Winchester syndrome , Vinorelbine , Wissler-Fanconi syndrome , Wolcott-Rallison syndrome

### Causes in Alphabetical Order

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* Acromegaly
* Acute tropical polyarthritis
* Alpha-interferon induced
* Alphaviruses
* Amyloidosis
* Ankylosing spondylitis
* Anticoagulant therapy
* Arboviruses
* Bacterial Endocarditis
* Behcet's Syndrome
* Calcium oxalate
* Calcium/phosphate crystals
* Crohn's Disease
* Degenerative joint disease
* Dermatomyositis
* Diabetes Mellitus
* Enterobacteriaceae
* Enteroviruses
* Epstein-Barr Virus
* Erythema Nodosum
* Fabry's Disease
* Familial Mediterranean Fever
* Foreign body
* Fungal infection
* Gaucher's Disease
* Gonococcus
* Gout
* Gram-Negative Bacilli
* Haemophilus influenzae
* Hemangioma
* Hemarthrosis
* Hemochromatosis

* Hemoglobinopathies
* Hemophilia
* Henoch-Schonlein Purpura
* Hepatitis A
* Hepatitis B
* Hepatitis C
* HIV
* Hydroxyapatite
* Hyperglobulinemic Purpura
* Hyperlipoproteinemia
* Hypogammaglobulinemia
* Hypothyroidism
* Hypotrophic osteoarthropathy
* Intermittent hydrarthrosis
* Juvenile Rheumatoid Arthritis
* Leukemia
* Loose joint body
* Lyme Arthritis
* Lymphoma
* Mixed Connective Tissue Disease
* Multiple Myeloma
* Mumps
* Neisseria gonorrhoeae
* Nilutamide
* Pallindromic rheumatism
* Pancreatic carcinoma
* Pancreatitis
* Parasitic infection
* Parvovirus B19
* Pergolide
* Pigmented villondular synovitis
* Pneumococcus
* Polyarteritis Nodosa
* Polymyalgia Rheumatica

* Polymyositis
* Pseudogout
* Psoriasis
* Radiation
* Reiter's Syndrome
* Relapsing polychondritis
* Renal transplant
* Rheumatic Fever
* Rheumatoid arthritis
* Rickettsial infection
* Rubella
* Sarcoma
* Scleroderma
* Septic Arthritis
* Serum sickness
* Sjogren's Syndrome
* Staphylococcus
* Storage Disease
* Streptococcus
* Syringomyelia
* Systemic Lupus Erythematosus
* Tabes Dorsalis
* Tiagabine
* Tietze's Syndrome
* Trauma
* Tuberculosis
* Ulcerative colitis
* Varicella Zoster Virus
* Von Willenbrand's Disease
* Wegener's Granulomatosis
* Whipple's Disease
* Wilson's Disease

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## References

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