Aspirin (rectal)

Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  Ammu Susheela, M.D. [2]

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## Overview

Aspirin (rectal) is an analgesic that is FDA approved for the treatment of minor aches, pains and headache and for reduction of fever. Common adverse reactions include hypoprothrombinemia, thrombocytopenia, hypersensitivity, cholestatic hepatitis, and tinnitus.

## Adult Indications and Dosage

### FDA-Labeled Indications and Dosage (Adult)

##### Indication

* For the relief of minor aches, pains and headache and for reduction of fever.

##### Dosage

Remove suppository from plastic packet and insert into the rectum as far as possible. Adult: One suppository every 4 hours for no more than 10 days or as directed by a physician. Children under 12 years of age: Consult a physician.

### Off-Label Use and Dosage (Adult)

#### Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Aspirin (rectal) in adult patients.

#### Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Aspirin (rectal) in adult patients.

## Pediatric Indications and Dosage

### FDA-Labeled Indications and Dosage (Pediatric)

There is limited information regarding FDA-Labeled Use of Aspirin (rectal) in pediatric patients.

### Off-Label Use and Dosage (Pediatric)

#### Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Aspirin (rectal) in pediatric patients.

#### Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Aspirin (rectal) in pediatric patients.

## Contraindications

There is limited information regarding Aspirin (rectal) Contraindications in the drug label.

## Warnings

There is limited information regarding Aspirin (rectal) Warnings' in the drug label.

## Adverse Reactions

### Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Aspirin (rectal) in the drug label.

### Postmarketing Experience

Hypoprothrombinemia, thrombocytopenia, hypersensitivity, cholestatic hepatitis, tinnitus

## Drug Interactions

* Drug

* Description

## Use in Specific Populations

#### Pregnancy

Pregnancy Category (FDA):

* Pregnancy Category

Pregnancy Category (AUS):

* Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Aspirin (rectal) in women who are pregnant.

#### Labor and Delivery

There is no FDA guidance on use of Aspirin (rectal) during labor and delivery.

#### Nursing Mothers

There is no FDA guidance on the use of Aspirin (rectal) with respect to nursing mothers.

#### Pediatric Use

There is no FDA guidance on the use of Aspirin (rectal) with respect to pediatric patients.

#### Geriatic Use

There is no FDA guidance on the use of Aspirin (rectal) with respect to geriatric patients.

#### Gender

There is no FDA guidance on the use of Aspirin (rectal) with respect to specific gender populations.

#### Race

There is no FDA guidance on the use of Aspirin (rectal) with respect to specific racial populations.

#### Renal Impairment

There is no FDA guidance on the use of Aspirin (rectal) in patients with renal impairment.

#### Hepatic Impairment

There is no FDA guidance on the use of Aspirin (rectal) in patients with hepatic impairment.

#### Females of Reproductive Potential and Males

There is no FDA guidance on the use of Aspirin (rectal) in women of reproductive potentials and males.

#### Immunocompromised Patients

There is no FDA guidance one the use of Aspirin (rectal) in patients who are immunocompromised.

## Administration and Monitoring

#### Administration

* Rectal

#### Monitoring

There is limited information regarding Monitoring of Aspirin (rectal) in the drug label.

## IV Compatibility

There is limited information regarding IV Compatibility of Aspirin (rectal) in the drug label.

## Overdosage

There is limited information regarding Aspirin (rectal) overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

## Pharmacology

Template:Px

Aspirin (rectal)

Systematic (IUPAC) name
2-(acetoxy)benzoic acid
Identifiers
CAS number | 50-78-2
ATC code | A01AD05 B01AC06 (WHO), N02BA01 (WHO)
PubChem | 2244
DrugBank | DB00945
Chemical data
Formula | Template:OrganicBox atomTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox atomTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBoxTemplate:OrganicBox
Mol. mass | 180.157 g/mol
SMILES | eMolecules & PubChem
Synonyms | 2-acetoxybenzoic acid
acetylsalicylate
acetylsalicylic acid
O-acetylsalicylic acid
Physical data
Density | 1.40 g/cm³
Melt. point | 136 °C (277 °F)
Boiling point | 140 °C (284 °F) (decomposes)
Solubility in water | 3 mg/mL (20 °C)
Pharmacokinetic data
Bioavailability | 80–100%[1]
Protein binding | 80–90%[2]
Metabolism | Hepatic, (CYP2C19 and possibly CYP3A), some is also hydrolysed to salicylate in the gut wall.[2]
Half life | Dose-dependent; 2–3 hours for low doses, 15–30 hours for large doses.[2]
Excretion | Urine (80–100%), sweat, saliva, feces[1]
Therapeutic considerations
Pregnancy cat. |

C(AU) C(US)

Legal status |

Pharmacy Only (S2)(AU) GSL(UK) OTC(US)

Routes | Most commonly oral, also rectal, lysine acetylsalicylate may be given intravenously or intramuscularly

### Mechanism of Action

There is limited information regarding Aspirin (rectal) Mechanism of Action in the drug label.

### Structure

There is limited information regarding Aspirin (rectal) Structure in the drug label.

### Pharmacodynamics

There is limited information regarding Pharmacodynamics of Aspirin (rectal) in the drug label.

### Pharmacokinetics

There is limited information regarding Pharmacokinetics of Aspirin (rectal) in the drug label.

### Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Aspirin (rectal) in the drug label.

## Clinical Studies

There is limited information regarding Clinical Studies of Aspirin (rectal) in the drug label.

## How Supplied

* Suppositories sealed in imprinted plastic packet.

### Storage

* Do not use if imprinted packet is opened or damaged. Store in a cool place 8˚- 15˚C (46˚- 59˚F) or refrigerate.

## Images

### Drug Images

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### Package and Label Display Panel

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## Patient Counseling Information

There is limited information regarding Patient Counseling Information of Aspirin (rectal) in the drug label.

## Precautions with Alcohol

* Alcohol-Aspirin (rectal) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

## Brand Names

* ASPIRIN®[3]

## Look-Alike Drug Names

There is limited information regarding Aspirin (rectal) Look-Alike Drug Names in the drug label.

## Drug Shortage Status

## Price

## References

The contents of this FDA label are provided by the National Library of Medicine.

1. ↑ 1.0 1.1 "Zorprin, Bayer Buffered Aspirin (aspirin) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 3 April 2014.
2. ↑ 2.0 2.1 2.2 Brayfield, A, ed. (14 January 2014). "Aspirin". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 3 April 2014.
3. ↑ "ASPIRIN- aspirin suppository".

CME Category::Cardiology