Astrocytoma risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  Fahimeh Shojaei, M.D.

## Overview[edit | edit source]

Common risk factors in the development of astrocytoma include environmental factors such as vinyl chloride, phenols, organic solvents, pesticides, formaldehyde, lubricating fluids, polycyclic aromatic hydrocarbons, and past radiation therapy to the brain and genetic diseases such as neurofibromatosis, tuberous sclerosis, Li-Fraumeni syndrome, nevoid basal cell carcinoma syndrome, Turcot syndrome and melanoma-astrocytoma syndrome. Less common risk factors include blood group A, previous head trauma, history of meningitis, history of epilepsy.

## Risk Factors[edit | edit source]

### Common Risk Factors[edit | edit source]

* Environmental risk factors:
* Exposure to:[1]
1. Vinyl chloride
2. Phenols
3. Organic solvents
4. Pesticides
5. Formaldehyde
6. Lubricating fluids
7. Polycyclic aromatic hydrocarbons
* Past radiation therapy to the brain[2]
* Genetic risk factors:[3][4][5]
* Neurofibromatosis
* Tuberous sclerosis
* Li-Fraumeni syndrome
* Nevoid basal cell carcinoma syndrome
* Turcot syndrome
* Melanoma-astrocytoma syndrome

### Less Common Risk Factors[edit | edit source]

* Blood group A[6][7]
* Previous head trauma[8]
* History of meningitis
* History of epilepsy[7]

## References[edit | edit source]

1. ↑ Caporalini C, Buccoliero AM, Scoccianti S, Moscardi S, Simoni A, Pansini L, Bordi L, Ammannati F, Taddei GL (2016). "Granular cell astrocytoma: report of a case and review of the literature". Clin. Neuropathol. 35 (4): 186–93. doi:10.5414/NP300952. PMID 27125869.
2. ↑ Sheppard JP, Nguyen T, Alkhalid Y, Beckett JS, Salamon N, Yang I (April 2018). "Risk of Brain Tumor Induction from Pediatric Head CT Procedures: A Systematic Literature Review". Brain Tumor Res Treat. 6 (1): 1–7. doi:10.14791/btrt.2018.6.e4. PMC 5932294. PMID 29717567.
3. ↑ Soura E, Eliades PJ, Shannon K, Stratigos AJ, Tsao H (March 2016). "Hereditary melanoma: Update on syndromes and management: Genetics of familial atypical multiple mole melanoma syndrome". J. Am. Acad. Dermatol. 74 (3): 395–407, quiz 408–10. doi:10.1016/j.jaad.2015.08.038. PMC 4761105. PMID 26892650.
4. ↑ Chourmouzi D, Papadopoulou E, Konstantinidis M, Syrris V, Kouskouras K, Haritanti A, Karkavelas G, Drevelegas A (June 2014). "Manifestations of pilocytic astrocytoma: a pictorial review". Insights Imaging. 5 (3): 387–402. doi:10.1007/s13244-014-0328-2. PMC 4035491. PMID 24789122.
5. ↑ Gajavelli S, Nakhla J, Nasser R, Yassari R, Weidenheim KM, Graber J (2016). "Ollier disease with anaplastic astrocytoma: A review of the literature and a unique case". Surg Neurol Int. 7 (Suppl 23): S607–11. doi:10.4103/2152-7806.189731. PMC 5025950. PMID 27656320.
6. ↑ BUCKWALTER JA, TURNER JH, GAMBER HH, RATERMAN L, SOPER RT, KNOWLER LA (April 1959). "Psychoses, intracranial neoplasms, and genetics". AMA Arch Neurol Psychiatry. 81 (4): 480–5. PMID 13636517.
7. ↑ 7.0 7.1 Schlehofer B, Blettner M, Becker N, Martinsohn C, Wahrendorf J (May 1992). "Medical risk factors and the development of brain tumors". Cancer. 69 (10): 2541–7. PMID 1568177.
8. ↑ Hochberg F, Toniolo P, Cole P (November 1984). "Head trauma and seizures as risk factors of glioblastoma". Neurology. 34 (11): 1511–4. PMID 6493505.

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