Atherosclerosis causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Niloofarsadaat Eshaghhosseiny, MD[2]

Atherosclerosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Atherosclerosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Assessment of Cardiovascular Risk

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocadiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

ACC/AHA Guideline Recommendations

Assessment of cardiovascular risk

Secondary prevention

Case Studies

Case #1

Atherosclerosis causes On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Atherosclerosis causes

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Atherosclerosis causes

CDC on Atherosclerosis causes

Atherosclerosis causes in the news

Blogs on Atherosclerosis causes

Directions to Hospitals Treating Atherosclerosis

Risk calculators and risk factors for Atherosclerosis causes

## Overview[edit | edit source]

Atherosclerosis may be caused by inflamation,immunity or infection.Atherosclerosis is a disease with multiple genetic and environmental contributions. To review risk factors for the development of atherosclerosis, click here.

## Causes[edit | edit source]

### Life-threatening Causes[edit | edit source]

* Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.complications resulting from untreated atherosclerosis is common.
* Atherosclerosis is a life-threatening cause of acute cronary syndrome and stroke.

### Common Causes[edit | edit source]

Common causes of atherosclerosis may include:

* Immunity
* Inflamation
* Infections,such as geram negative sepsis,can cause type 2 acute cronary syndrome.[1]
* Smoking
* HTN
* HLP
* DM
* Kidney disease
* Adiposity[2]

### Less Common Causes[edit | edit source]

Less common causes of [disease name] include:

* [Cause1]
* [Cause2]
* [Cause3]

### Genetic Causes[edit | edit source]

* Atherosclerosis can caused by expression in the PCSK9 gene.[3]
* Mutation one of the three genes below can cause familal hypercholesterolemia:LDLR,APOB3,PCSK9.[4]
* In human nearly 40 quantitative trait loci have been found for atherosclerosis.[5]

### Causes by Organ System[edit | edit source]

Cardiovascular | No underlying causes

|

Chemical/Poisoning | No underlying causes
Dental | No underlying causes
Dermatologic | No underlying causes
Drug Side Effect | No underlying causes
Ear Nose Throat | No underlying causes
Endocrine | No underlying causes
Environmental | No underlying causes
Gastroenterologic | No underlying causes
Genetic | No underlying causes
Hematologic | No underlying causes
Iatrogenic | No underlying causes
Infectious Disease | No underlying causes
Musculoskeletal/Orthopedic | No underlying causes
Neurologic | No underlying causes
Nutritional/Metabolic | No underlying causes
Obstetric/Gynecologic | No underlying causes
Oncologic | No underlying causes
Ophthalmologic | No underlying causes
Overdose/Toxicity | No underlying causes
Psychiatric | No underlying causes
Pulmonary | No underlying causes
Renal/Electrolyte | No underlying causes
Rheumatology/Immunology/Allergy | No underlying causes
Sexual | No underlying causes
Trauma | No underlying causes
Urologic | No underlying causes
Miscellaneous | No underlying causes

### Causes in Alphabetical Order[edit | edit source]

List the causes of the disease in alphabetical order:

* Cause 1
* Cause 2
* Cause 3
* Cause 4
* Cause 5
* Cause 6
* Cause 7
* Cause 8
* Cause 9
* Cause 10

## References[edit | edit source]

1. ↑ Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V; et al. (2018). "Inflammation, Immunity, and Infection in Atherothrombosis: JACC Review Topic of the Week". J Am Coll Cardiol. 72 (17): 2071–2081. doi:10.1016/j.jacc.2018.08.1043. PMC 6196735. PMID 30336831.CS1 maint: Multiple names: authors list (link)
2. ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID doi.org/10.1161 Check `|pmid=` value (help).CS1 maint: Multiple names: authors list (link)
3. ↑ Ferri N, Tibolla G, Pirillo A, Cipollone F, Mezzetti A, Pacia S; et al. (2012). "Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels". Atherosclerosis. 220 (2): 381–6. doi:10.1016/j.atherosclerosis.2011.11.026. PMID 22176652.CS1 maint: Multiple names: authors list (link)
4. ↑ Sjouke B, Kusters DM, Kindt I, Besseling J, Defesche JC, Sijbrands EJ; et al. (2015). "Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome". Eur Heart J. 36 (9): 560–5. doi:10.1093/eurheartj/ehu058. PMID 24585268.CS1 maint: Multiple names: authors list (link)
5. ↑ Chen Y, Rollins J, Paigen B, Wang X (2007). "Genetic and genomic insights into the molecular basis of atherosclerosis". Cell Metab. 6 (3): 164–79. doi:10.1016/j.cmet.2007.07.001. PMC 2083632. PMID 17767904.CS1 maint: Multiple names: authors list (link)

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