Autocrine signalling

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List of terms related to Autocrine signalling

Autocrine signaling is a form of signaling in which a cell secretes a hormone, or chemical messenger (called the autocrine agent) that binds to autocrine receptors on the same cell, leading to changes in the cell. This can be contrasted with paracrine signaling, intracrine signaling, or classical endocrine signalling.

## Examples

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An example of an autocrine agent is the cytokine interleukin-1 in monocytes. When this is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it.

Another example occurs in activated T cell lymphocytes, i.e. when a T cell is induced to mature by binding to a peptide:MHC complex on a professional antigen presenting cell and by the B7:CD28 costimulatory signal. Upon activation, "low affinity" IL-2 receptors are replaced by "high affinity" IL-2 receptors consisting of α, β, and γ chains. The cell then releases IL-2 which binds to its own new IL-2 receptors, causing self-stimulation and ultimately a monoclonal population of T cells. These T cells can then go on to perform effector functions such as macrophage activation, B cell activation, and cell-mediated cytoxicity.

## See also

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* Paracrine signaling
* Intracrine
* Endocrine system

## External links

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* Template:GPnotebook
* Autocrine+signaling at the US National Library of Medicine Medical Subject Headings (MeSH)
* Template:Dorlands
* "Autocrine versus juxtacrine signaling modes" - illustration at sysbio.org

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Cell signaling / Signal transduction

Signaling pathways|

* GPCR
*   * Wnt
* RTK
* TGF beta
* MAPK/ERK
* Notch
* JAK-STAT
* Akt/PKB
* Fas apoptosis
* Hippo
* PI3K/AKT/mTOR pathway
* Integrin receptors

Agents|

| Receptor ligands|

* Hormones
* Neurotransmitters/Neuropeptides/Neurohormones
* Cytokines
* Growth factors
* Signaling molecules

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Receptors|

* Cell surface
* Intracellular
* Co-receptor

Second messenger|

* cAMP-dependent pathway
* Ca2+ signaling
* Lipid signaling

Assistants:|

* Signal transducing adaptor protein
* Scaffold protein

Transcription factors|

* General
* Transcription preinitiation complex
* TFIID
* TFIIH

By distance|

* Juxtacrine
* Autocrine / Paracrine
* Endocrine

Other concepts|

* Intracrine action
* Neurocrine signaling
* Synaptic transmission
* Chemical synapse
* Neuroendocrine signaling
* Exocrine signalling
* Pheromones
* Mechanotransduction
* Phototransduction
* Ion channel gating
* Gap junction

it:Autocrino sv:Autokrin

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