Bone marrow disorders

For congenital bone marrow disorders, click here.
For acquired bone marrow disorders, click here.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:  Yazan Daaboul, M.D.; Rim Halaby, M.D. [2]; Serge Korjian M.D.

## Overview[edit | edit source]

Bone marrow disorders are classified into congenital bone marrow disorders and acquired bone marrow disorders.

## Definition of Terms[edit | edit source]

* Bone marrow suppression: Reduced numbers of cells in the bone marrow
* Myelosuppression: Reduced number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
* Immunosuppression or lymphosuppression: Reduced number of lymphoid lineage cells (T-cell, B-cell, NK cell)

* Bone marrow proliferation: Increased numbers of cells in the bone marrow
* Myeloproliferation: Increased number of myeloid lineage cells (RBC, neutrophils, basophils, eosinophils, monocytes, platelets, mastocytes)
* Immunoproliferation or lymphoproliferation: Increased number of lymphoid lineage cells (T-cell, B-cell, NK cell)

## Classification[edit | edit source]

Shown below is an algorithm depicting the different classes of bone marrow disorders.

| Bone Marrow Disorders|

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Acquired disorders of the bone marrow

Congenital disorders of the bone marrow

Bone marrow suppression

Bone marrow proliferation

Mixed or unclassified

Bone marrow suppression

Bone marrow proliferation

Myelosuppression|

| Immunosuppression|

| Myeloproliferation|

| Immunoproliferation|

| Multiple lineages|

| Single lineage|

## References[edit | edit source]