Bovine spongiform encephalopathy classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief:  Adnan Ezici, M.D[2]

## Overview

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Based on the biochemical signatures of the disease-associated prion protein, Bovine spongiform encephalopahty (BSE) may be classified as either classic or atypical. Atypical BSE may further be classified into H- and L-types. Due to the accumulation of amyloid protein in the brain in cattles with L-type BSE, its also known as bovine amyloidotic spongiform encephalopathy (BASE).

## Classification

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Based on the biochemical signatures of the disease-associated prion protein, Bovine spongiform encephalopahty (BSE) may be classified as either classic or atypical. Atypical BSE may further be classified into H- and L-types. Due to the accumulation of amyloid protein in the brain in cattles with L-type BSE, its also known as bovine amyloidotic spongiform encephalopathy (BASE). [1][2]

## References

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1. ↑ Casalone C, Hope J (2018). "Atypical and classic bovine spongiform encephalopathy". Handb Clin Neurol. 153: 121–134. doi:10.1016/B978-0-444-63945-5.00007-6. PMID 29887132.
2. ↑ Costassa EV, Iulini B, Mazza M, Acutis P, Maurella C, Meloni D, Pautasso A, Capucci L, Bozzetta E, Simmons MM, Zanusso G, Pocchiari M, Corona C, Casalone C (December 2016). "Pathogenesis and Transmission of Classical and Atypical BSE in Cattle". Food Saf (Tokyo). 4 (4): 130–134. doi:10.14252/foodsafetyfscj.2016018. PMC 6989206 Check `|pmc=` value (help). PMID 32231917 Check `|pmid=` value (help).

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