CC chemokine receptors

CCR1

Identifiers
Symbol| CCR1
Entrez| 1230
HUGO| 1602
OMIM| 601159
RefSeq| NM_001295
UniProt| P32246
Other data
Locus| Chr. 3 p21
CCR2

Identifiers
Symbol| CCR2
Entrez| 1231
HUGO| 1603
OMIM| 601268
PDB| 1KAD
RefSeq| NM_000647
UniProt| P41597
Other data
Locus| Chr. 3 p21
CCR3

Identifiers
Symbol| CCR3
Entrez| 1232
HUGO| 1604
OMIM| 601268
RefSeq| NM_001837
UniProt| P51677
Other data
Locus| Chr. 3 p21
CCR4

Identifiers
Symbol| CCR4
Entrez| 1233
HUGO| 1605
OMIM| 604836
RefSeq| NM_005508
UniProt| P51679
Other data
Locus| Chr. 3 p24
CCR5

Identifiers
Symbol| CCR5
Entrez| 1234
HUGO| 1606
OMIM| 601373
PDB| 1ND8
RefSeq| NM_000579
UniProt| P51681
Other data
Locus| Chr. 3 p21
CCR6

Identifiers
Symbol| CCR6
Entrez| 1235
HUGO| 1607
OMIM| 601835
RefSeq| NM_004367
UniProt| P51684
Other data
Locus| Chr. 6 q27
CCR7

Identifiers
Symbol| CCR7
Entrez| 1236
HUGO| 1608
OMIM| 600242
RefSeq| NM_001838
UniProt| P32248
Other data
Locus| Chr. 17 q12-q21.2
CCR8

Identifiers
Symbol| CCR8
Entrez| 1237
HUGO| 1609
OMIM| 601834
RefSeq| NM_005201
UniProt| P51685
Other data
Locus| Chr. 3 p22
CCR9

Identifiers
Symbol| CCR9
Entrez| 10803
HUGO| 1610
OMIM| 604738
RefSeq| NM_031200
UniProt| P51686
Other data
Locus| Chr. 3 p21
CCR10

Identifiers
Symbol| CCR10
Entrez| 2826
HUGO| 4474
OMIM| 600240
RefSeq| NM_016602
UniProt| P46092
Other data
Locus| Chr. 17 17q21.1-q21

CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to cytokines of the CC chemokine family. They represent one subfamily of chemokine receptors, a large family of G protein-linked receptors that are known as seven transmembrane (7-TM) proteins since they span the cell membrane seven times. To date, ten true members of the CC chemokine receptor subfamily have been described. These are named CCR1 to CCR10 according to the IUIS/WHO Subcommittee on Chemokine Nomenclature.

## Contents

* 1 Mechanism
* 2 Types
* 2.1 Overview table
* 2.2 CCR1
* 2.3 CCR2
* 2.4 CCR3
* 2.5 CCR4
* 2.6 CCR5
* 2.7 CCR6
* 2.8 CCR7
* 2.9 CCR8
* 2.10 CCR9
* 2.11 CCR10
* 2.12 CCR11
* 3 References
* 4 External links

## Mechanism

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The CC chemokine receptors all work by activating the G protein Gi.[1]

## Types

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### Overview table

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Receptor | Ligands

|

CCR1 | CCL4, CCL5, CCL6, CCL14, CCL15, CCL16, CCL23
CCR2 | CCL2, CCL8, CCL16
CCR3 | CCL11, CCL26, CCL7, CCL13, CCL15, CCL24, CCL5, CCL28, CCL18
CCR4 | CCL3, CCL5, CCL17, CCL22
CCR5 | CCL3, CCL4, CCL5, CCL8, CCL11, CCL13, CCL14, CCL16
CCR6 | CCL20
CCR7 | CCL19, CCL21
CCR8 | CCL1, CCL16
CCR9 | CCL25
CCR10 | CCL27, CCL28
CCR11 | CCL19, CCL21, CCL25

### CCR1

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CCR1 was the first CC chemokine receptor identified and binds multiple inflammatory/inducible (see inducible gene) CC chemokines (including CCL4, CCL5, CCL6, CCL14, CCL15, CCL16 and CCL23).[2][3][4][5] In humans, this receptor can be found on peripheral blood lymphocytes and monocytes. There is some suggestion that this chemokine receptor is restricted to memory T-cells within the lymphocyte pool. This receptor is also designated cluster of differentiation marker CD191.

### CCR2

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CCR2 can interact with CCL2, CCL8 and CCL16 and has been identified on the surface of monocytes, activated memory T cells, B cells, and basophils in humans, and also in peritoneal macrophages in mice.[4][6] CCR2 is also designated CD192.

### CCR3

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CCR3 is a receptor for multiple inflammatory/inducible CC chemokines, including CCL11, CCL26, CCL7, CCL13, CCL15, CCL24 and CCL5 that attract eosinophils, and CCL28 that attracts B and T lymphocytes to mucosal tissues. [3][7][8][9][10] It is most highly expressed in both eosinophils and basophils, but can also be found in Th1 and Th2 cells and airway epithelial cells. Thus CCR3 plays a role in allergic reactions. CCR3 is also known as CD193.

### CCR4

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CCR4 is expressed on Th2 T lymphocytes and is up-regulated by T cell receptor activation. However, some reports suggest a role for this receptor also in trafficking of dendritic cells. The CC chemokines CCL3, CCL5, CCL17 and CCL22 signal through this receptor.[11][12]

### CCR5

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CCR5 is expressed on several cell types including peripheral blood-derived dendritic cells, CD34+ hematopoietic progenitor cells and certain activated/memory Th1 lymphocytes. This receptor is well defined as a major coreceptor implicated in susceptibility to HIV-1 infection and disease. This receptor has several CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14 and CCL16.[4][6][13][14]

### CCR6

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CCR6, a receptor for CCL20, is expressed on unactivated memory T-cells and some dendritic cells. CCR6 is also expressed on Th17 cells.[15] CCR6 is down-regulated in activated T-cells.[16]

### CCR7

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CCR7 is a highly important receptor with a role in trafficking of B and T lymphocytes and dendritic cells to and across high endothelial venules and positioning those cells correctly in T cell zones of secondary lymphoid organs. Its ligands include the related chemokines CCL19 and CCL21, (previously called ELC and SLC).[17]

### CCR8

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CCR8 is associated with Th2 lymphocytes and is therefore found predominantly in the thymus (in humans) although some expression can be found in the brain, spleen, lymph node, and monocytes at the nucleotide level. The ligands for this receptor are CCL1 and CCL16.[18]

### CCR9

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CCR9 was previously called orphan receptor GPR 9-6 and is very highly expressed in thymus (on both immature and mature T-cells) while low in lymph nodes and spleen. CCR9 is also abundant in the gut, with its expression associated with T cells of the intestine. The specific ligand of this receptor is CCL25.[19] To note, the chemokine binding protein D6 had previously been named CCR9, but this molecule is a scavenger receptor not a true (signaling) chemokine receptor.

### CCR10

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CCR10 is receptor for CCL27 and CCL28 that was originally called orphan receptor GPR2.[9][20][21][22] CCR10 has been implicated in inflammation of the skin, and has been shown to recruit regulatory T cells (Tregs) to mucosal layers.

### CCR11

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This molecule was originally designated CCR11 due to its ability to bind several CC chemokines (including CCL19, CCL21 and CCL25) and its structural similarity to chemokine receptors. However, due to the inability of this molecule (also known as CCRL1 and CCX CKR) to generate a signal following ligand interaction, it has been suggested that it is a scavenger receptor for chemokines and not a bona fide chemokine receptor. Thus CCRL1 should not be called CCR11 under the guidelines of the IUIS/WHO Subcommittee on Chemokine Nomenclature.

## References

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1. ↑ senselab
2. ↑ Ma et al. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1;172(3):1872-81.
3. ↑ 3.0 3.1 Youn et al. Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3. J. Immun. 159: 5201-5205, 1997.
4. ↑ 4.0 4.1 4.2 Nomiyama et al. Human CC chemokine liver-expressed chemokine/CCL16 is a functional ligand for CCR1, CCR2 and CCR5, and constitutively expressed by hepatocytes. Int Immunol. 2001 Aug;13(8):1021-9.
5. ↑ Berahovich et al. Proteolytic Activation of Alternative CCR1 Ligands in Inflammation. J. Immunol. 174:7341-7351, 2005.
6. ↑ 6.0 6.1 Ogilvie et al. Eotaxin is a natural antagonist for CCR2 and an agonist for CCR5. Blood. 2001, 97:1920-4
7. ↑ Kitaura et al. Molecular cloning of human eotaxin, an eosinophil-selective CC chemokine, and identification of a specific eosinophil eotaxin receptor, CC chemokine receptor 3. J. Biol. Chem. 1996, 271:7725-7730.
8. ↑ Kitaura et al. Molecular cloning of a novel human CC chemokine (Eotaxin-3) that is a functional ligand of CC chemokine receptor 3. J. Biol. Chem. 274:27975-27980, 1999.
9. ↑ 9.0 9.1 Pan et al. 2000, A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues, J. Immunol. 165: 2943–2949.
10. ↑ White et al. Cloning and functional characterization of a novel human CC chemokine that binds to the CCR3 receptor and activates human eosinophils. J. Leukoc. Biol. 62:667-675, 1997.
11. ↑ Imai et al. The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 272: 15036-15042, 1997.
12. ↑ Imai et al. Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J. Biol. Chem. 273:1764-1768 (1998).
13. ↑ Gong et al., Monocyte Chemotactic Protein-2 Activates CCR5 and Blocks CD4/CCR5-mediated HIV-1 Entry/Replication. J Biol Chem, 1998, 273,4289-4292.
14. ↑ Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.
15. ↑ Acosta-Rodriguez et al., Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells. Nat. Immunology, 2007, 6, 639-646.
16. ↑ Baba et al., Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J Biol Chem. 1997, 272:14893-8.
17. ↑ Yoshida et al. Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific ligand for EBI1, CCR7. J. Biol. Chem. 272: 13803-13809, 1997.
18. ↑ Roos et al., Identification of CCR8, the receptor for the human CC chemokine I-309. J Biol Chem 1997 Vol 272, 17251–4.
19. ↑ Zaballos et al., Identification of the orphan chemokine receptor GPR-9-6 as CCR9, the receptor for the chemokine TECK. J. Immunol., 1999, 162:5671-5675.
20. ↑ Gosling et al., Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J Immunol. 2000, 164:2851-6.
21. ↑ Homey et al. The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ILC). J. Immunol. 164:3465-3470, 2000.
22. ↑ Wang et al. 2000, Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275: 22313–22323.

## External links

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* "Chemokine Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

* v
* t
* e

Transmembrane receptors: immunoglobulin superfamily immune receptors

Antibody receptor:
Fc receptor|

| Epsilon (ε)|

* FcεRI
* (FcεRII is C-type lectin)

|

Gamma (γ)|

* FcγRI
* FcγRII
* FcγRIII
* Neonatal

Alpha (α)/mu (μ)|

* FcαRI
* Fcα/μR

Secretory|

* Polymeric immunoglobulin receptor

Antigen receptor|

| B cells|

| Antigen receptor|

* BCR

|

Co-receptor|

| stimulate:|

* CD21/CD19/CD81

|

inhibit:|

* CD22

Accessory molecules|

* Ig-α/Ig-β (CD79)

T cells|

| Ligands|

* MHC
* MHC class I
* MHC class II

|

Antigen receptor|

* TCR: TRA@
* TRB@
* TRD@
* TRG@

Co-receptors|

* CD8 (with two glycoprotein chains CD8α and CD8β)
* CD4

Accessory molecules|

* CD3
* CD3γ
* CD3δ
* CD3ε
* ζ-chain (also called CD3ζ and TCRζ)

Cytokine receptor|

* see cytokine receptors

Killer-cell IG-like receptors|

* KIR2DL1
* KIR2DL2
* KIR2DL3
* KIR2DL4
* KIR2DL5A
* KIR2DL5B
* KIR2DS1
* KIR2DS2
* KIR2DS3
* KIR2DS4
* KIR2DS5
* KIR3DL1
* KIR3DL2
* KIR3DL3
* KIR3DS1

Leukocyte IG-like receptors|

* LILRA1
* LILRA2
* LILRA3
* LILRA4
* LILRA5
* LILRA6
* LILRB1
* LILRB2
* LILRB3
* LILRB4
* LILRB5
* LILRA6
* LILRA5

* v
* t
* e

Cytokine receptors

Chemokine receptor
(GPCRs)|

| CC|

* CCR1 / CCRL1
* CCR2
* CCRL2
* CCR3
* CCR4
* CCR5
* CCR6
* CCR7
* CCR8
* CCR9
* CCR10

|

CXC|

* IL-8
* CXCR1
* CXCR2
* CXCR3
* CXCR4
* CXCR5
* CXCR6
* CXCR7

Other|

* CX3C
* CX3CR1
* XC
* XCR1
* CCBP2
* CMKLR1

TNF receptor|

| 1-10|

* TNFR1 (TNFRSF1A)
* TNFR2 (TNFRSF1B)
* LTBR (TNFRSF3)
* CD134 (TNFRSF4)
* CD40 (TNFRSF5)
* Fas receptor (TNFRSF6)
* DcR3 (TNFRSF6B)
* CD27 (TNFRSF7)
* CD30 (TNFRSF8)
* CD137 (TNFRSF9)

|

11-20|

* DR4 (TNFRSF10A)
* DR5 (TNFRSF10B)
* DcR1 (TNFRSF10C)
* DcR2 (TNFRSF10D)
* RANK (TNFRSF11A)
* Osteoprotegerin (TNFRSF11B)
* TweakR (TNFRSF12A)
* TACI (TNFRSF13B)
* BAFFR (TNFRSF13C)
* HVEM (TNFRSF14)
* NGFR (TNFRSF16)
* BCMA (TNFRSF17)
* GITR (TNFRSF18)
* TAJ/TROY (TNFRSF19)

21-27|

* DR6 (TNFRSF21)
* DR3 (TNFRSF25)
* EDA2R (TNFRSF27)

JAK-STAT|

| Type I|

| γ-chain|

* Interleukin receptors
* IL2R / IL2RA/IL2RB / IL15R
* IL4R / IL13R / IL13RA1 / IL13RA2
* IL7R / IL7RA
* IL9R
* IL21R

|

β-chain|

* Interleukin receptors
* IL3R / IL3RA
* IL5R / IL5RA
* GM-CSF

gp130|

* Interleukin receptors
* IL6RA
* 11/IL11RA
* 27/IL27RA
* OSMR
* LIFR
* CNTFR

IL12RB1|

* Interleukin receptors
* IL12R/IL12RB1/IL12RB2
* IL23R23

Other|

* other CSF receptors
* EPO
* G-CSF
* Thrombopoietin

* hormone receptor: GH
* prolactin

Type II|

* Interleukin receptors
* IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
* IL20R / IL20RA / IL20RB
* IL28R
* Interferon receptors
* -α/β / IFNAR1/IFNAR2
* -γ/IFNGR1 / IFNGR2

Ig superfamily|

* CSF1
* KIT
* IL1
* IL1R1
* IL1R2
* IL18R / IL18R1

IL 17 family|

* IL17
* IL17RA
* IL17RB
* IL17RC
* IL17RD
* IL17RE

S/T|

* TGF-beta
* TGFBR1
* TGFBR2

* v
* t
* e

Chemokine receptor modulators

CC|

| CCR1|

* Agonists: CCL4 (MIP-1β)
* CCL5 (RANTES)
* CCL6
* CCL9 (CCL10)
* CCL14
* CCL15
* CCL16
* CCL23

|

CCR2|

* Agonists: CCL2
* CCL8
* CCL12
* CCL16

* NAMs: Cenicriviroc (TAK-652, TBR-652)

CCR3|

* Agonists: CCL5 (RANTES)
* CCL7
* CCL11
* CCL13
* CCL15
* CCL18
* CCL24
* CCL26
* CCL28

CCR4|

* Agonists: CCL3 (MIP-1α)
* CCL5 (RANTES)
* CCL17
* CCL22

* Antibodies: Mogamulizumab (against CCR4)

CCR5|

* Agonists: CCL3 (MIP-1α)
* CCL4 (MIP-1β)
* CCL5 (RANTES)
* CCL8
* CCL11
* CCL13
* CCL14
* CCL16

* NAMs: Aplaviroc
* Cenicriviroc (TAK-652, TBR-652)
* INCB009471
* Maraviroc
* Vicriviroc

* Antibodies: PRO-140

CCR6|

* Agonists: CCL20

CCR7|

* Agonists: CCL19
* CCL21

CCR8|

* Agonists: CCL1
* CCL16

CCR9|

* Agonists: CCL25

CCR10|

* Agonists: CCL27
* CCL28

CCR11|

* Agonists: CCL19
* CCL21
* CCL25

Ungrouped|

* Antibodies: Bertilimumab (against CCL11)
* Carlumab (against CCL2)

CXC|

| CXCR1
(IL-8Rα)|

* Agonists: CXCL6
* Emoctakin
* Interleukin-8 (CXCL8, GCP-1)

* Antagonists: Navarixin

* NAMs: Ladarixin
* Reparixin (repertaxin)

|

CXCR2
(IL-8Rβ)|

* Agonists: CXCL1 (MGSA)
* CXCL2
* CXCL3
* CXCL5
* CXCL6
* CXCL7
* Emoctakin
* Garnocestim
* Interleukin-8 (CXCL8, GCP-1)

* Antagonists: Danirixin
* Elubrixin
* Navarixin

* NAMs: Ladarixin
* Reparixin (repertaxin)

CXCR3|

* Agonists: CXCL4 (PF4)
* CXCL9 (MIG)
* CXCL10 (IP-10)
* CXCL11 (I-TAC)
* Iroplact

* Antibodies: Eldelumab (against CXCL10)

CXCR4|

* Agonists: MIF
* SDF-1 (CXCL12)
* Ubiquitin

* Antagonists: Mavorixafor
* Plerixafor (AMD3100)

* Antibodies: Ulocuplumab (against CXCR4)

CXCR5|

* Agonists: CXCL13

CXCR6|

* Agonists: CXCL16

CXCR7|

* Agonists: CXCL11 (I-TAC)
* SDF-1 (CXCL12)

* PAMs: Plerixafor (AMD3100)

C (XC)|

| XCR1|

* Agonists: Lymphotactin-α (XCL1)
* Lymphotactin-β (XCL2)

* Antibodies: Pateclizumab

|

CX3C|

| CX3CR1|

* Agonists: Fractalkine (CX3CL1)

|

Others|

| CCBP2|

* Agonists: CC (β) chemokines

|

CMKLR1|

* Agonists: Chemerin
* Resolvin E1

See also
Receptor/signaling modulators
Signaling peptide/protein receptor modulators
Cytokine receptor modulators
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