CD64 (biology)

Fc fragment of IgG, high affinity Ia, receptor (CD64)

Identifiers
Symbol| FCGR1A
Entrez| 2209
HUGO| 3613
OMIM| 146760
RefSeq| NM_000566
UniProt| P12314
Other data
Locus| Chr. 1 q21.2-21.3
Fc fragment of IgG, high affinity Ib, receptor (CD64)

Identifiers
Symbol| FCGR1B
Entrez| 2210
HUGO| 3614
OMIM| 601502
RefSeq| NM_001004340
UniProt| Q92637
Other data
Locus| Chr. 1 p11.2
Fc fragment of IgG, high affinity Ic, receptor (CD64)

Identifiers
Symbol| FCGR1C
Entrez| 2211
HUGO| 3615
OMIM| 601503
RefSeq| XM_001133198
Other data
Locus| Chr. 1 q21.1

CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity.[1] It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation.[2]

Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail.[3]

CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.[4][5]

There are three distinct (but highly similar) genes in humans for CD64 called FcγRIA (CD64A), FcγRIB (CD64B), and FcγRIC (CD64C) that are located on chromosome 1.[6] These three genes produce six different mRNA transcripts; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing of the genes.[3]

## References

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1. ↑ Hulett M, Hogarth P (1998). "The second and third extracellular domains of FcgammaRI (CD64) confer the unique high affinity binding of IgG2a". Mol Immunol. 35 (14–15): 989–96. doi:10.1016/S0161-5890(98)00069-8. PMID 9881694.
2. ↑ Nimmerjahn F, Ravetch J (2006). "Fcgamma receptors: old friends and new family members". Immunity. 24 (1): 19–28. doi:10.1016/j.immuni.2005.11.010. PMID 16413920.
3. ↑ 3.0 3.1 Ernst L, Duchemin A, Miller K, Anderson C (1998). "Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts". Mol Immunol. 35 (14–15): 943–54. PMID 9881690.
4. ↑ Perussia B, Dayton E, Lazarus R, Fanning V, Trinchieri G (1983). "Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells". J Exp Med. 158 (4): 1092–113. doi:10.1084/jem.158.4.1092. PMC 2187379. PMID 6225822.
5. ↑ Repp R, Valerius T, Sendler A, Gramatzki M, Iro H, Kalden J, Platzer E (1991). "Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor". Blood. 78 (4): 885–9. PMID 1714327.
6. ↑ Ernst L, van de Winkel J, Chiu I, Anderson C (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". J Biol Chem. 267 (22): 15692–700. PMID 1379234.

## External links

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* CD64+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50|

* CD1
* a-c
* 1A
* 1D
* 1E
* CD2
* CD3
* γ
* δ
* ε
* CD4
* CD5
* CD6
* CD7
* CD8
* a
* CD9
* CD10
* CD11
* a
* b
* c
* d
* CD13
* CD14
* CD15
* CD16
* A
* B
* CD18
* CD19
* CD20
* CD21
* CD22
* CD23
* CD24
* CD25
* CD26
* CD27
* CD28
* CD29
* CD30
* CD31
* CD32
* A
* B
* CD33
* CD34
* CD35
* CD36
* CD37
* CD38
* CD39
* CD40
* CD41
* CD42
* a
* b
* c
* d
* CD43
* CD44
* CD45
* CD46
* CD47
* CD48
* CD49
* a
* b
* c
* d
* e
* f
* CD50

51-100|

* CD51
* CD52
* CD53
* CD54
* CD55
* CD56
* CD57
* CD58
* CD59
* CD61
* CD62
* E
* L
* P
* CD63
* CD64
* A
* B
* C
* CD66
* a
* b
* c
* d
* e
* f
* CD68
* CD69
* CD70
* CD71
* CD72
* CD73
* CD74
* CD78
* CD79
* a
* b
* CD80
* CD81
* CD82
* CD83
* CD84
* CD85
* a
* d
* e
* h
* j
* k
* CD86
* CD87
* CD88
* CD89
* CD90
* CD91 \- CD92
* CD93
* CD94
* CD95
* CD96
* CD97
* CD98
* CD99
* CD100

101-150|

* CD101
* CD102
* CD103
* CD104
* CD105
* CD106
* CD107
* a
* b
* CD108
* CD109
* CD110
* CD111
* CD112
* CD113
* CD114
* CD115
* CD116
* CD117
* CD118
* CD119
* CD120
* a
* b
* CD121
* a
* b
* CD122
* CD123
* CD124
* CD125
* CD126
* CD127
* CD129
* CD130
* CD131
* CD132
* CD133
* CD134
* CD135
* CD136
* CD137
* CD138
* CD140b
* CD141
* CD142
* CD143
* CD144
* CD146
* CD147
* CD148
* CD150

151-200|

* CD151
* CD152
* CD153
* CD154
* CD155
* CD156
* a
* b
* c
* CD157
* CD158 (a
* d
* e
* i
* k)
* CD159
* a
* c
* CD160
* CD161
* CD162
* CD163
* CD164
* CD166
* CD167
* a
* b
* CD168
* CD169
* CD170
* CD171
* CD172
* a
* b
* g
* CD174
* CD177
* CD178
* CD179
* a
* b
* CD180
* CD181
* CD182
* CD183
* CD184
* CD185
* CD186
* CD191
* CD192
* CD193
* CD194
* CD195
* CD196
* CD197
* CDw198
* CDw199
* CD200

201-250|

* CD201
* CD202b
* CD204
* CD205
* CD206
* CD207
* CD208
* CD209
* CDw210
* a
* b
* CD212
* CD213a
* 1
* 2
* CD217
* CD218 (a
* b)
* CD220
* CD221
* CD222
* CD223
* CD224
* CD225
* CD226
* CD227
* CD228
* CD229
* CD230
* CD233
* CD234
* CD235
* a
* b
* CD236
* CD238
* CD239
* CD240CE
* CD240D
* CD241
* CD243
* CD244
* CD246
* CD247 \- CD248
* CD249

251-300|

* CD252
* CD253
* CD254
* CD256
* CD257
* CD258
* CD261
* CD262
* CD263
* CD264
* CD265
* CD266
* CD267
* CD268
* CD269
* CD271
* CD272
* CD273
* CD274
* CD275
* CD276
* CD278
* CD279
* CD280
* CD281
* CD282
* CD283
* CD284
* CD286
* CD288
* CD289
* CD290
* CD292
* CDw293
* CD294
* CD295
* CD297
* CD298
* CD299

301-350|

* CD300A
* CD301
* CD302
* CD303
* CD304
* CD305
* CD306
* CD307
* CD309
* CD312
* CD314
* CD315
* CD316
* CD317
* CD318
* CD320
* CD321
* CD322
* CD324
* CD325
* CD326
* CD328
* CD329
* CD331
* CD332
* CD333
* CD334
* CD335
* CD336
* CD337
* CD338
* CD339
* CD340
* CD344
* CD349
* CD350

* v
* t
* e

Cluster of differentiation by lineage

Lymphoid|

| B cell|

* Pre-B cell: CD10/CALLA
* CD79A

* mature: CD19
* CD20
* CD21/CR2
* CD23/FcεRII
* CD127
* CD40

* plasma cell: CD38
* CD138

|

T/NK|

| T cell|

* Pan-T antigens: CD3
* CD7

* CD1
* CD4
* CD8
* CD13
* CD18
* CD26
* CD27
* CD28

|

NK cell|

* CD16
* CD56/NCAM
* CD57

All|

* CD2

All|

* CD5

Myeloid|

| CFU-GM/
Myelomonocyte|

* CD11c
* CD14
* CD15
* CD31
* CD64
* CD68

|

MEP|

| CFU-Meg|

* CD34/CD36
* CD42
* CD41/CD61

|

CFU-E|

* CD36
* CD71

All (pan-myeloid)|

* CD13
* CD33

Stem cell|

* CD34

* v
* t
* e

Transmembrane receptors: immunoglobulin superfamily immune receptors

Antibody receptor:
Fc receptor|

| Epsilon (ε)|

* FcεRI
* (FcεRII is C-type lectin)

|

Gamma (γ)|

* FcγRI
* FcγRII
* FcγRIII
* Neonatal

Alpha (α)/mu (μ)|

* FcαRI
* Fcα/μR

Secretory|

* Polymeric immunoglobulin receptor

Antigen receptor|

| B cells|

| Antigen receptor|

* BCR

|

Co-receptor|

| stimulate:|

* CD21/CD19/CD81

|

inhibit:|

* CD22

Accessory molecules|

* Ig-α/Ig-β (CD79)

T cells|

| Ligands|

* MHC
* MHC class I
* MHC class II

|

Antigen receptor|

* TCR: TRA@
* TRB@
* TRD@
* TRG@

Co-receptors|

* CD8 (with two glycoprotein chains CD8α and CD8β)
* CD4

Accessory molecules|

* CD3
* CD3γ
* CD3δ
* CD3ε
* ζ-chain (also called CD3ζ and TCRζ)

Cytokine receptor|

* see cytokine receptors

Killer-cell IG-like receptors|

* KIR2DL1
* KIR2DL2
* KIR2DL3
* KIR2DL4
* KIR2DL5A
* KIR2DL5B
* KIR2DS1
* KIR2DS2
* KIR2DS3
* KIR2DS4
* KIR2DS5
* KIR3DL1
* KIR3DL2
* KIR3DL3
* KIR3DS1

Leukocyte IG-like receptors|

* LILRA1
* LILRA2
* LILRA3
* LILRA4
* LILRA5
* LILRA6
* LILRB1
* LILRB2
* LILRB3
* LILRB4
* LILRB5
* LILRA6
* LILRA5

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