CLIP1

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Identifiers
Aliases|
External IDs| GeneCards: [1]
Orthologs
Species| Human| Mouse
Entrez| |

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Ensembl| |

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UniProt| |

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RefSeq (mRNA)| |

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Location (UCSC)| n/a| n/a
PubMed search| n/a| n/a
Wikidata
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CAP-GLY domain containing linker protein 1, also known as CLIP1, is a protein which in humans is encoded by the CLIP1 gene.[1]

## Contents

* 1 Interactions
* 2 References
* 3 External links
* 4 Further reading

## Interactions

[edit | edit source]

CLIP1 has been shown to interact with IQGAP1,[2] Mammalian target of rapamycin[3] and PAFAH1B1.[4]

## References

[edit | edit source]

1. ↑ "Entrez Gene: CLIP1 CAP-GLY domain containing linker protein 1".
2. ↑ Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell. 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184.
3. ↑ Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports. 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
4. ↑ Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology. 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.

## External links

[edit | edit source]

* Human CLIP1 genome location and CLIP1 gene details page in the UCSC Genome Browser.

## Further reading

[edit | edit source]

* Galjart N (Jun 2005). "CLIPs and CLASPs and cellular dynamics". Nature Reviews Molecular Cell Biology. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712.
* Pierre P, Scheel J, Rickard JE, Kreis TE (Sep 1992). "CLIP-170 links endocytic vesicles to microtubules". Cell. 70 (6): 887–900. doi:10.1016/0092-8674(92)90240-D. PMID 1356075.
* Bilbe G, Delabie J, Brüggen J, Richener H, Asselbergs FA, Cerletti N, Sorg C, Odink K, Tarcsay L, Wiesendanger W (Jun 1992). "Restin: a novel intermediate filament-associated protein highly expressed in the Reed-Sternberg cells of Hodgkin's disease". The EMBO Journal. 11 (6): 2103–13. PMC 556677. PMID 1600942.
* Pierre P, Pepperkok R, Kreis TE (Jul 1994). "Molecular characterization of two functional domains of CLIP-170 in vivo". Journal of Cell Science. 107 (7): 1909–20. PMID 7983157.
* Hilliker C, Delabie J, Speleman F, Bilbe G, Bruggen J, Van Leuven F, Van den Berghe H (1993). "Localization of the gene (RSN) coding for restin, a marker for Reed-Sternberg cells in Hodgkin's disease, to human chromosome band 12q24.3 and YAC cloning of the locus". Cytogenetics and Cell Genetics. 65 (3): 172–6. doi:10.1159/000133625. PMID 8222754.
* Griparic L, Keller TC (Oct 1998). "Identification and expression of two novel CLIP-170/Restin isoforms expressed predominantly in muscle". Biochimica et Biophysica Acta. 1405 (1–3): 35–46. doi:10.1016/S0167-4889(98)00096-2. PMID 9784600.
* Perez F, Diamantopoulos GS, Stalder R, Kreis TE (Feb 1999). "CLIP-170 highlights growing microtubule ends in vivo". Cell. 96 (4): 517–27. doi:10.1016/S0092-8674(00)80656-X. PMID 10052454.
* Akhmanova A, Hoogenraad CC, Drabek K, Stepanova T, Dortland B, Verkerk T, Vermeulen W, Burgering BM, De Zeeuw CI, Grosveld F, Galjart N (Mar 2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts". Cell. 104 (6): 923–35. doi:10.1016/S0092-8674(01)00288-4. PMID 11290329.
* Coquelle FM, Caspi M, Cordelières FP, Dompierre JP, Dujardin DL, Koifman C, Martin P, Hoogenraad CC, Akhmanova A, Galjart N, De Mey JR, Reiner O (May 2002). "LIS1, CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology. 22 (9): 3089–102. doi:10.1128/MCB.22.9.3089-3102.2002. PMC 133759. PMID 11940666.
* Griffith KJ, Ryan JP, Senécal JL, Fritzler MJ (Mar 2002). "The cytoplasmic linker protein CLIP-170 is a human autoantigen". Clinical and Experimental Immunology. 127 (3): 533–8. doi:10.1046/j.1365-2249.2002.01756.x. PMC 1906301. PMID 11966772.
* Fukata M, Watanabe T, Noritake J, Nakagawa M, Yamaga M, Kuroda S, Matsuura Y, Iwamatsu A, Perez F, Kaibuchi K (Jun 2002). "Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170". Cell. 109 (7): 873–85. doi:10.1016/S0092-8674(02)00800-0. PMID 12110184.
* Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF (Oct 2002). "The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase". EMBO Reports. 3 (10): 988–94. doi:10.1093/embo-reports/kvf197. PMC 1307618. PMID 12231510.
* Sahin U, Neumann F, Tureci O, Schmits R, Perez F, Pfreundschuh M (Dec 2002). "Hodgkin and Reed-Sternberg cell-associated autoantigen CLIP-170/restin is a marker for dendritic cells and is involved in the trafficking of macropinosomes to the cytoskeleton, supporting a function-based concept of Hodgkin and Reed-Sternberg cells". Blood. 100 (12): 4139–45. doi:10.1182/blood.V100.12.4139. PMID 12433698.
* Goodson HV, Skube SB, Stalder R, Valetti C, Kreis TE, Morrison EE, Schroer TA (Jul 2003). "CLIP-170 interacts with dynactin complex and the APC-binding protein EB1 by different mechanisms". Cell Motility and the Cytoskeleton. 55 (3): 156–73. doi:10.1002/cm.10114. PMID 12789661.
* Ho SM, Lau KM, Mok SC, Syed V (Jul 2003). "Profiling follicle stimulating hormone-induced gene expression changes in normal and malignant human ovarian surface epithelial cells". Oncogene. 22 (27): 4243–56. doi:10.1038/sj.onc.1206437. PMID 12833147.
* Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
* Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
* Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K (Dec 2004). "Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration". Developmental Cell. 7 (6): 871–83. doi:10.1016/j.devcel.2004.10.017. PMID 15572129.

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PDB gallery

* 2cp5: Solution structure of the 1st CAP-Gly domain in human CLIP-170/restin

2cp5: Solution structure of the 1st CAP-Gly domain in human CLIP-170/restin

* 2cp6: Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin

2cp6: Solution structure of the 2nd CAP-Gly domain in human CLIP-170/restin

* 2cp7: Solution structure of the 1st CAP-Gly domain in mouse CLIP-170/restin

2cp7: Solution structure of the 1st CAP-Gly domain in mouse CLIP-170/restin

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