COPE (gene)

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Identifiers
Aliases|
External IDs| GeneCards: [1]
Orthologs
Species| Human| Mouse
Entrez| |

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Ensembl| |

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UniProt| |

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RefSeq (mRNA)| |

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RefSeq (protein)| |

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Location (UCSC)| n/a| n/a
PubMed search| n/a| n/a
Wikidata
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Coatomer subunit epsilon is a protein that in humans is encoded by the COPE gene.[1][2]

## Contents

* 1 Function
* 2 Interactions
* 3 References
* 4 External links
* 5 Further reading

## Function

[edit | edit source]

The product of this gene is an epsilon subunit of coatomer protein complex. Coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles. It is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. Coatomer complex consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.[2]

## Interactions

[edit | edit source]

COPE (gene) has been shown to interact with COPA.[3][4][5]

## References

[edit | edit source]

1. ↑ Shima DT, Scales SJ, Kreis TE, Pepperkok R (November 1999). "Segregation of COPI-rich and anterograde-cargo-rich domains in endoplasmic-reticulum-to-Golgi transport complexes". Curr. Biol. 9 (15): 821–4. doi:10.1016/S0960-9822(99)80365-0. PMID 10469566.
2. ↑ 2.0 2.1 "Entrez Gene: COPE coatomer protein complex, subunit epsilon".
3. ↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
4. ↑ Eugster A, Frigerio G, Dale M, Duden R (August 2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873.
5. ↑ Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (October 1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex". J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028. PMID 8858162.

## External links

[edit | edit source]

* Human COPE genome location and COPE gene details page in the UCSC Genome Browser.

## Further reading

[edit | edit source]

* Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
* Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins from the cytosol". Nature. 364 (6439): 732–4. doi:10.1038/364732a0. PMID 8355790.
* Faulstich D, Auerbach S, Orci L, Ravazzola M, Wegchingel S, Lottspeich F, Stenbeck G, Harter C, Wieland FT, Tschochner H (1996). "Architecture of coatomer: molecular characterization of delta-COP and protein interactions within the complex" (PDF). J. Cell Biol. 135 (1): 53–61. doi:10.1083/jcb.135.1.53. PMC 2121028. PMID 8858162.
* Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
* Pavel J, Harter C, Wieland FT (1998). "Reversible dissociation of coatomer: functional characterization of a beta/delta-coat protein subcomplex". Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2140–5. doi:10.1073/pnas.95.5.2140. PMC 19276. PMID 9482852.
* de La Vega LA, Stockert RJ (1999). "The cytoplasmic coatomer protein COPI. A potential translational regulator". J. Biol. Chem. 274 (44): 31135–8. doi:10.1074/jbc.274.44.31135. PMID 10531302.
* Eugster A, Frigerio G, Dale M, Duden R (2000). "COP I domains required for coatomer integrity, and novel interactions with ARF and ARF-GAP". EMBO J. 19 (15): 3905–17. doi:10.1093/emboj/19.15.3905. PMC 306616. PMID 10921873.
* Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
* Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
* Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
* Zhang T, Hong W (2001). "Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport". J. Biol. Chem. 276 (29): 27480–7. doi:10.1074/jbc.M102786200. PMID 11323436.
* Xu Y, Martin S, James DE, Hong W (2002). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus". Mol. Biol. Cell. 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMC 129961. PMID 12388752.
* Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
* Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
* Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

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Membrane protein: vesicular transport proteins (TC 1F)

Synaptic vesicle|

| SNARE|

| Q-SNARE|

* SNAP25
* SNAP29

* Syntaxin
* STX1A
* STX1B
* STX2
* STX3
* STX4
* STX5
* STX6
* STX7
* STX8
* STX10
* STX11
* STX12
* STX16
* STX17
* STX18
* STX19

* Munc-18: STXBP1
* STXBP2
* STXBP3
* STXBP4
* STXBP5
* STXBP6

|

R-SNARE|

* Synaptobrevin/VAMP: VAMP1
* VAMP2
* VAMP3

Synaptotagmin|

* SYT1
* SYT2
* SYT3
* SYT4
* SYT5
* SYT6
* SYT7
* SYT8
* SYT9
* SYT10
* SYT11
* SYT12
* SYT13
* SYT14
* SYT15
* SYT16
* SYT17

Other|

* Synaptophysin
* Synapsin

* Small GTPase: RAB3A

COPI|

* Coatomer
* COPA
* COPB1
* COPB2
* COPD/Archain
* COPE
* COPG
* COPG2
* COPZ1
* COPZ2

* Small GTPase: ARF

COPII|

* Coatomer
* SEC23A/SEC24A
* SEC13/SEC31

* Small GTPase: SAR1A

RME/Clathrin|

* CLTA
* CLTB
* CLTC

Caveolae|

* Caveolin (CAV1
* CAV2
* CAV3)

Other/ungrouped|

| Vesicle formation|

| Adaptor protein complex 1:|

* AP1AR
* AP1B1
* AP1G1
* AP1G2
* AP1M1
* AP1M2
* AP1S1
* AP1S2
* AP1S3

|

Adaptor protein complex 2:|

* AP2A1
* AP2A2
* AP2B1
* AP2M1
* AP2S1

Adaptor protein complex 3:|

* AP3B1
* AP3B2
* AP3D1
* AP3M1
* AP3M2
* AP3S1
* AP3S2

Adaptor protein complex 4:|

* AP4B1
* AP4E1
* AP4M1
* AP4S1

* LMAN1

* LYST

BLOC-1:|

* DTNBP1
* BLOC153

BLOC-2:|

* HPS3
* HPS5
* HPS6

BLOC-3:|

* HPS1
* HPS4

Coats:|

* Retromer
* TIP47

Small GTPase|

* Dynamin
* DNM1
* DNM2
* DNM3

Other|

* EHD protein family: EHD1
* EHD2
* EHD3
* EHD4

* Sorting nexins

* Vacuolar protein sorting: VPS13B
* VPS33B

* SYNRG

See also vesicular transport protein disorders

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