CUL7

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Identifiers
Aliases|
External IDs| GeneCards: [1]
Orthologs
Species| Human| Mouse
Entrez| |

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Ensembl| |

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UniProt| |

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RefSeq (mRNA)| |

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RefSeq (protein)| |

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Location (UCSC)| n/a| n/a
PubMed search| n/a| n/a
Wikidata
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Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.[1][2][3]

## Contents

* 1 Clinical significance
* 2 Interactions
* 3 References
* 4 Further reading
* 5 External links

## Clinical significance

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It is associated with 3-M syndrome.

## Interactions

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CUL7 has been shown to interact with RBX1.[1]

## References

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1. ↑ 1.0 1.1 Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
2. ↑ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A. 100 (17): 9855–60. doi:10.1073/pnas.1733908100. PMC 187864. PMID 12904573.
3. ↑ "Entrez Gene: CUL7 cullin 7".

## Further reading

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* Kim SS, Shago M, Kaustov L, et al. (2007). "CUL7 is a novel antiapoptotic oncogene". Cancer Res. 67 (20): 9616–22. doi:10.1158/0008-5472.CAN-07-0644. PMID 17942889.
* Jung P, Verdoodt B, Bailey A, et al. (2007). "Induction of cullin 7 by DNA damage attenuates p53 function". Proc. Natl. Acad. Sci. U.S.A. 104 (27): 11388–93. doi:10.1073/pnas.0609467104. PMC 2040908. PMID 17586686.
* Skaar JR, Florens L, Tsutsumi T, et al. (2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.
* Kaustov L, Lukin J, Lemak A, et al. (2007). "The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53". J. Biol. Chem. 282 (15): 11300–7. doi:10.1074/jbc.M611297200. PMID 17298945.
* Kasper JS, Arai T, DeCaprio JA (2006). "A novel p53-binding domain in CUL7". Biochem. Biophys. Res. Commun. 348 (1): 132–8. doi:10.1016/j.bbrc.2006.07.013. PMID 16875676.
* Andrews P, He YJ, Xiong Y (2006). "Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function". Oncogene. 25 (33): 4534–48. doi:10.1038/sj.onc.1209490. PMID 16547496.
* Huber C, Dias-Santagata D, Glaser A, et al. (2005). "Identification of mutations in CUL7 in 3-M syndrome". Nat. Genet. 37 (10): 1119–24. doi:10.1038/ng1628. PMID 16142236.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
* Winston JT, Koepp DM, Zhu C, et al. (1999). "A family of mammalian F-box proteins". Curr. Biol. 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
* Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi:10.1093/dnares/1.5.223. PMID 7584044.

## External links

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* GeneReviews/NIH/NCBI/UW entry on 3-M syndrome
* OMIM entries entry on 3-M syndrome
* Human CUL7 genome location and CUL7 gene details page in the UCSC Genome Browser.

* v
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* e

PDB gallery

* 2jng: Solution structure of the CUL7-CPH domain from Homo Sapiens; Northeast Structural Genomics Consortium target HT1.

2jng: Solution structure of the CUL7-CPH domain from Homo Sapiens; Northeast Structural Genomics Consortium target HT1.

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Cell cycle proteins

Cyclin|

* A (A1, A2)
* B (B1, B2, B3)
* D (D1, D2, D3)
* E (E1, E2)

CDK|

* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10
* CDK-activating kinase

CDK inhibitor|

* INK4a/ARF (p14arf/p16, p15, p18, p19)
* cip/kip (p21, p27, p57)

P53 p63 p73 family|

* p53
* p63
* p73

Other|

* Cdc2
* Cdc25
* Cdc42
* Cellular apoptosis susceptibility protein
* E2F
* Maturation promoting factor
* Wee
* Cullin (CUL7)

Phases and
checkpoints|

| Interphase|

* G1 phase
* S phase
* G2 phase

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M phase|

* Mitosis (Preprophase
* Prophase
* Prometaphase
* Metaphase
* Anaphase
* Telophase)
* Cytokinesis

Cell cycle checkpoints|

* Restriction point
* Spindle checkpoint
* Postreplication checkpoint

Other cellular phases|

* Apoptosis
* G0 phase
* Meiosis

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