Cancer of unknown primary origin causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ; Roukoz A. Karam, M.D.[2]

## Overview[edit | edit source]

The cause of cancer of unknown primary origin has not been identified.

## Causes[edit | edit source]

* The cause of cancer of unknown primary origin has not been identified.
* Several studies have evaluated the chromosomal and molecular anomalies found in cancers of unknown primary; however, they could not identify unique causes of metastasis of unknown primaries relative to those with known primary origins.
* Overexpression of several genes has been noted in patients with cancer of unknown primary including Ras, p53, Bcl-2, and Her-2.[1][2]

## References[edit | edit source]

1. ↑ Hainsworth JD, Lennington WJ, Greco FA (2000). "Overexpression of Her-2 in patients with poorly differentiated carcinoma or poorly differentiated adenocarcinoma of unknown primary site". J Clin Oncol. 18 (3): 632–5. doi:10.1200/JCO.2000.18.3.632. PMID 10653878.CS1 maint: Multiple names: authors list (link)
2. ↑ Briasoulis E, Tsokos M, Fountzilas G, Bafaloukos D, Kosmidis P, Samantas E; et al. (1998). "Bcl2 and p53 protein expression in metastatic carcinoma of unknown primary origin: biological and clinical implications. A Hellenic Co-operative Oncology Group study". Anticancer Res. 18 (3B): 1907–14. PMID 9677443.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

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