Cannabinoid receptor 1 (brain)

Identifiers
Symbols|  CNR1 ; CANN6; CB-R; CB1; CB1A; CB1K5; CNR
External IDs|  Template:OMIM5 Template:MGI HomoloGene: 7273
| Gene ontology

Molecular function | Template:GNF GO Template:GNF GO
Cellular component | Template:GNF GO Template:GNF GO
Biological process | Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE CNR1 208243 s at tn.png
File:PBB GE CNR1 207940 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species|  Human|  Mouse
Entrez|  n/a|  n/a
Ensembl|  n/a|  n/a
UniProt|  n/a|  n/a
RefSeq (mRNA)|  n/a|  n/a
RefSeq (protein)|  n/a|  n/a
Location (UCSC)|  n/a|  n/a
PubMed search|  n/a|  n/a

Cannabinoid receptor 1 (brain), also known CB1 or CNR1, is a human gene.[1]

This gene encodes a protein that is one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the family of guanine-nucleotide-binding protein (G-protein) coupled receptors which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Two transcript variants encoding different isoforms have been described for this gene.[1]

## See also

[edit | edit source]

* Cannabinoid receptor

## References

[edit | edit source]

1. ↑ 1.0 1.1 "Entrez Gene: CNR1 cannabinoid receptor 1 (brain)".

## Further reading

[edit | edit source]

* Oddi S, Spagnuolo P, Bari M; et al. (2007). "Differential modulation of type 1 and type 2 cannabinoid receptors along the neuroimmune axis". Int. Rev. Neurobiol. 82: 327–37. doi:10.1016/S0074-7742(07)82017-4. PMID 17678969.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Gérard CM, Mollereau C, Vassart G, Parmentier M (1991). "Molecular cloning of a human cannabinoid receptor which is also expressed in testis". Biochem. J. 279 ( Pt 1): 129–34. PMID 1718258.CS1 maint: Multiple names: authors list (link)
* Hoehe MR, Caenazzo L, Martinez MM; et al. (1991). "Genetic and physical mapping of the human cannabinoid receptor gene to chromosome 6q14-q15". New Biol. 3 (9): 880–5. PMID 1931832.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Matsuda LA, Lolait SJ, Brownstein MJ; et al. (1990). "Structure of a cannabinoid receptor and functional expression of the cloned cDNA". Nature. 346 (6284): 561–4. doi:10.1038/346561a0. PMID 2165569.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Gérard C, Mollereau C, Vassart G, Parmentier M (1991). "Nucleotide sequence of a human cannabinoid receptor cDNA". Nucleic Acids Res. 18 (23): 7142. PMID 2263478.CS1 maint: Multiple names: authors list (link)
* Shire D, Carillon C, Kaghad M; et al. (1995). "An amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing". J. Biol. Chem. 270 (8): 3726–31. PMID 7876112.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
* Kenney SP, Kekuda R, Prasad PD; et al. (1999). "Cannabinoid receptors and their role in the regulation of the serotonin transporter in human placenta". Am. J. Obstet. Gynecol. 181 (2): 491–7. PMID 10454705.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Porcella A, Maxia C, Gessa GL, Pani L (2000). "The human eye expresses high levels of CB1 cannabinoid receptor mRNA and protein". Eur. J. Neurosci. 12 (3): 1123–7. PMID 10762343.CS1 maint: Multiple names: authors list (link)
* Mukhopadhyay S, Howlett AC (2001). "CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains". Eur. J. Biochem. 268 (3): 499–505. PMID 11168387.
* Murphy WJ, Eizirik E, Johnson WE; et al. (2001). "Molecular phylogenetics and the origins of placental mammals". Nature. 409 (6820): 614–8. doi:10.1038/35054550. PMID 11214319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Nong L, Newton C, Friedman H, Klein TW (2002). "CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types". Adv. Exp. Med. Biol. 493: 229–33. PMID 11727770.CS1 maint: Multiple names: authors list (link)
* Leroy S, Griffon N, Bourdel MC; et al. (2002). "Schizophrenia and the cannabinoid receptor type 1 (CB1): association study using a single-base polymorphism in coding exon 1". Am. J. Med. Genet. 105 (8): 749–52. PMID 11803524.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Schmidt LG, Samochowiec J, Finckh U; et al. (2002). "Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence". Drug and alcohol dependence. 65 (3): 221–4. PMID 11841893.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lastres-Becker I, Cebeira M, de Ceballos ML; et al. (2002). "Increased cannabinoid CB1 receptor binding and activation of GTP-binding proteins in the basal ganglia of patients with Parkinson's syndrome and of MPTP-treated marmosets". Eur. J. Neurosci. 14 (11): 1827–32. PMID 11860478.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Petrelli A, Gilestro GF, Lanzardo S; et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature. 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Huang SM, Bisogno T, Trevisani M; et al. (2002). "An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors". Proc. Natl. Acad. Sci. U.S.A. 99 (12): 8400–5. doi:10.1073/pnas.122196999. PMID 12060783.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Ujike H, Takaki M, Nakata K; et al. (2002). "CNR1, central cannabinoid receptor gene, associated with susceptibility to hebephrenic schizophrenia". Mol. Psychiatry. 7 (5): 515–8. doi:10.1038/sj.mp.4001029. PMID 12082570.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Ho BY, Current L, Drewett JG (2002). "Role of intracellular loops of cannabinoid CB(1) receptor in functional interaction with G(alpha16)". FEBS Lett. 522 (1–3): 130–4. PMID 12095632.CS1 maint: Multiple names: authors list (link)
* Matias I, Pochard P, Orlando P; et al. (2002). "Presence and regulation of the endocannabinoid system in human dendritic cells". Eur. J. Biochem. 269 (15): 3771–8. PMID 12153574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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* v
* t
* e

|

* v
* t
* e

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

| Neurotransmitter|

| Adrenergic|

* α1 (A
* B
* D)
* α2 (A
* B
* C)
* β1
* β2
* β3

|

Purinergic|

* Adenosine (A1
* A2A
* A2B
* A3)
* P2Y (1
* 2
* 4
* 5
* 6
* 8
* 9
* 10
* 11
* 12
* 13
* 14)

Serotonin|

* (all but 5-HT3) 5-HT1 (A
* B
* D
* E
* F)
* 5-HT2 (A
* B
* C)
* 5-HT (4
* 5A
* 6
* 7)

Other|

* Acetylcholine (M1
* M2
* M3
* M4
* M5)
* Dopamine
* D1
* D2
* D3
* D4
* D5
* GHB receptor
* Histamine
* H1
* H2
* H3
* H4
* Melatonin (1A
* 1B
* 1C)
* TAAR (1
* 2
* 5
* 6
* 8
* 9)

Metabolites and
signaling molecules|

| Eicosanoid|

* CysLT (1
* 2)
* LTB4
* 1
* 2
* FPRL1
* OXE
* Prostaglandin
* DP (1
* 2), EP (1
* 2
* 3
* 4), FP
* Prostacyclin
* Thromboxane

|

Other|

* Bile acid
* Cannabinoid (CB1
* CB2, GPR (18
* 55
* 119))
* EBI2
* Estrogen
* Free fatty acid (1
* 2
* 3
* 4)
* Hydroxycarboxylic acids
* 1
* 2
* 3
* Lysophosphatidic acid (1
* 2
* 3
* 4
* 5
* 6)
* Lysophospholipid (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8)
* Oxoglutarate
* PAF
* Sphingosine-1-phosphate (1
* 2
* 3
* 4
* 5)
* Succinate

Peptide|

| Neuropeptide|

* B/W (1
* 2)
* FF (1
* 2)
* S
* Y (1
* 2
* 4
* 5)
* Neuromedin (B
* U (1
* 2))
* Neurotensin (1
* 2)

|

Other|

* Anaphylatoxin (C3a
* C5a)
* Angiotensin (1
* 2)
* Apelin
* Bombesin
* BRS3
* GRPR
* NMBR)
* Bradykinin (B1
* B2)
* Chemokine
* Cholecystokinin (A
* B)
* Endothelin
* A
* B
* Formyl peptide (1
* 2
* 3)
* FSH
* Galanin (1
* 2
* 3)
* Gonadotropin-releasing hormone (1
* 2)
* Ghrelin
* Kisspeptin
* Luteinizing hormone/choriogonadotropin
* MAS (1
* 1L
* D
* E
* F
* G
* X1
* X2
* X3
* X4)
* Melanocortin (1
* 2
* 3
* 4
* 5)
* MCHR (1
* 2)
* Motilin
* Opioid (Delta
* Kappa
* Mu
* Nociceptin & Zeta, but not Sigma)
* Orexin (1
* 2)
* Oxytocin
* Prokineticin (1
* 2)
* Prolactin-releasing peptide
* Relaxin (1
* 2
* 3
* 4)
* Somatostatin (1
* 2
* 3
* 4
* 5)
* Tachykinin (1
* 2
* 3)
* Thyrotropin
* Thyrotropin-releasing hormone
* Urotensin-II
* Vasopressin (1A
* 1B
* 2)

Miscellaneous|

| Orphan|

* GPR (1
* 3
* 4
* 6
* 12
* 15
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 25
* 26
* 27
* 31
* 32
* 33
* 34
* 35
* 37
* 39
* 42
* 44
* 45
* 50
* 52
* 55
* 61
* 62
* 63
* 65
* 68
* 75
* 77
* 78
* 81
* 82
* 83
* 84
* 85
* 87
* 88
* 92
* 101
* 103
* 109A
* 109B
* 119
* 120
* 132
* 135
* 137B
* 139
* 141
* 142
* 146
* 148
* 149
* 150
* 151
* 152
* 153
* 160
* 161
* 162
* 171
* 173
* 174
* 176
* 177
* 182
* 183)

|

Other|

* Adrenomedullin
* Olfactory
* Opsin (3
* 4
* 5
* 1LW
* 1MW
* 1SW
* RGR
* RRH)
* Protease-activated (1
* 2
* 3
* 4)
* SREB (1
* 2
* 3)

Class B: Secretin-like

| Adhesion|

* ADGRG (1
* 2
* 3
* 4
* 5
* 6
* 7)

|

Orphan|

* GPR (56
* 64
* 97
* 98
* 110
* 111
* 112
* 113
* 114
* 115
* 116
* 123
* 124
* 125
* 126
* 128
* 133
* 143
* 144
* 155
* 157)

Other|

* Brain-specific angiogenesis inhibitor (1
* 2
* 3)
* Cadherin (1
* 2
* 3)
* Calcitonin
* CALCRL
* CD97
* Corticotropin-releasing hormone (1
* 2)
* EMR (1
* 2
* 3)
* Glucagon (GR
* GIPR
* GLP1R
* GLP2R)
* Growth-hormone-releasing hormone
* PACAPR1
* GPR
* Latrophilin (1
* 2
* 3
* ELTD1)
* Methuselah-like proteins
* Parathyroid hormone (1
* 2)
* Secretin
* Vasoactive intestinal peptide (1
* 2)

Class C: Metabotropic glutamate / pheromone

| Taste|

* TAS1R (1
* 2
* 3)
* TAS2R (1
* 3
* 4
* 5
* 7
* 8
* 9
* 10
* 13
* 14
* 16
* 19
* 20
* 30
* 31
* 38
* 39
* 40
* 41
* 42
* 43
* 45
* 46
* 50
* 60
* Vomeronasal receptor)

|

Other|

* Calcium-sensing receptor
* GABAB (1
* 2)
* Glutamate receptor (Metabotropic glutamate (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8))
* GPRC6A
* GPR (156
* 158
* 179)
* RAIG (1
* 2
* 3
* 4)

Class F: Frizzled & Smoothened

| Frizzled|

* Frizzled (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10)

|

Smoothened|

* Smoothened

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