Carcinoma of the penis classification

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Editor(s)-in-Chief: C. Michael Gibson, M.S., M.D. [1] Phone:617-632-7753;  Swathi Venkatesan, M.B.B.S.[2]

## Overview

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Carcinoma of the penis may be classified according to cell types into several subtypes: squamous cell carcinoma, adenocarcinoma, melanoma, basal cell carcinoma, lymphoma, and sarcoma.

## Classification

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### Most common malignant penile tumours

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Squamous cell carcinoma[1][2][3]

* The most common type of penile cancer is squamous cell carcinoma (SCC).

* There are several subtypes of SCC:[4]

* Warty carcinoma (verruciform) and verrucous carcinoma

* Looks like a genital wart and may have a cauliflower-like appearance
* Usually slow growing, but they gradually enlarge and can spread deeply into surrounding tissue
* Rarely spread to lymph nodes or other parts of the body
* Often associated with human papillomavirus (HPV) infection

* Basaloid carcinoma

* Uncommon type of squamous cell penile cancer[5]
* Fast growing

* Sarcomatoid carcinoma

* Fast growing

### Rare malignant penile tumours

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* There are several rare types of penile cancer:

Adenocarcinoma"Penile Cancer: Introduction | Cancer.Net".

* Develops from sweat glands (glandular cells) in the skin of the penis
* Occurs much less often than SCC
* Also called Paget's disease of the penis

Melanoma

* Develops from skin cells called melanocytes
* Usually develops on sun-exposed areas of skin, but sometimes develops on the penis

Basal cell carcinoma

* A type of non-melanoma skin cancer
* Slow growing and rarely spreads to other areas of the body

Lymphoma

* A type of cancer that starts in immune cells of the lymphatic system

Sarcoma

* A type of cancer that starts in connective tissues (tissue that surrounds and supports various organs in the body)
* Starts in the connective and supporting tissues of the body
* Tends to be fast growing
* May include AIDS-related Kaposi sarcoma (KS)

## References

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1. ↑ Malignant tumours of the penis. Canadian Cancer Society 2015. http://www.cancer.ca/en/cancer-information/cancer-type/penile/penile-cancer/malignant-tumours/?region=ab
2. ↑ Cubilla AL, Velazquez EF, Amin MB, Epstein J, Berney DM, Corbishley CM; et al. (2018). "The World Health Organisation 2016 classification of penile carcinomas: a review and update from the International Society of Urological Pathology expert-driven recommendations". Histopathology. 72 (6): 893–904. doi:10.1111/his.13429. PMID 29105175.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
3. ↑ Marchionne, Elizabeth; Perez, Caroline; Hui, Andrea; Khachemoune, Amor (2017). "Penile squamous cell carcinoma: a review of the literature and case report treated with Mohs micrographic surgery". Anais Brasileiros de Dermatologia. 92 (1): 95–99. doi:10.1590/abd1806-4841.20175009. ISSN 0365-0596.
4. ↑ Thapa, Sushma; Ghosh, Arnab; Shrestha, Santosh; Ghartimagar, Dilasma; Narasimhan, Raghavan; Talwar, OP (2017). "Warty Carcinoma Penis: An Uncommon Variant". Case Reports in Pathology. 2017: 1–4. doi:10.1155/2017/2937592. ISSN 2090-6781.
5. ↑ Hakenberg, Oliver Walther; Dräger, Desiree Louise; Erbersdobler, Andreas; Naumann, Carsten Maik; Jünemann, Klaus-Peter; Protzel, Chris (2018). "The diagnosis and treatment of penile cancer". Deutsches Aerzteblatt Online. doi:10.3238/arztebl.2018.0646. ISSN 1866-0452.

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