Caseous necrosis

A high-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.
Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

WikiDoc Resources for Caseous necrosis

Articles

Most recent articles on Caseous necrosis

Most cited articles on Caseous necrosis

Review articles on Caseous necrosis

Articles on Caseous necrosis in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Caseous necrosis

Images of Caseous necrosis

Photos of Caseous necrosis

Podcasts & MP3s on Caseous necrosis

Videos on Caseous necrosis

Evidence Based Medicine

Cochrane Collaboration on Caseous necrosis

Bandolier on Caseous necrosis

TRIP on Caseous necrosis

Clinical Trials

Ongoing Trials on Caseous necrosis at Clinical Trials.gov

Trial results on Caseous necrosis

Clinical Trials on Caseous necrosis at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Caseous necrosis

NICE Guidance on Caseous necrosis

NHS PRODIGY Guidance

FDA on Caseous necrosis

CDC on Caseous necrosis

Books

Books on Caseous necrosis

News

Caseous necrosis in the news

Be alerted to news on Caseous necrosis

News trends on Caseous necrosis

Commentary

Blogs on Caseous necrosis

Definitions

Definitions of Caseous necrosis

Patient Resources / Community

Patient resources on Caseous necrosis

Discussion groups on Caseous necrosis

Patient Handouts on Caseous necrosis

Directions to Hospitals Treating Caseous necrosis

Risk calculators and risk factors for Caseous necrosis

Healthcare Provider Resources

Symptoms of Caseous necrosis

Causes & Risk Factors for Caseous necrosis

Diagnostic studies for Caseous necrosis

Treatment of Caseous necrosis

Continuing Medical Education (CME)

CME Programs on Caseous necrosis

International

Caseous necrosis en Espanol

Caseous necrosis en Francais

Business

Caseous necrosis in the Marketplace

Patents on Caseous necrosis

Experimental / Informatics

List of terms related to Caseous necrosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Caseous necrosis describes a form of biological tissue death. The dead tissue appears as a soft and white proteinaceous dead cell mass. Like most patterns of necrosis, no histological architecture is preserved - it is characterised by acellular pink areas of necrosis surrounded by a granulomatous inflammatory process. Frequently, caseous necrosis is associated with tuberculosis (TB).

When the hilar lymph node for instance is infected with tuberculosis and leads to caseous necrosis, it would appear to have a cheesy tan to white appearance, which is why this type of necrosis is often depicted as a combination of both coagulative and liquefactive necrosis.

However, in the lung, extensive caseous necrosis with confluent cheesy tan granulomas is typical. The tissue destruction is so extensive that there are areas of cavitation (also known as cystic spaces). See Ghon's complex.

## Contents

* 1 Pathological Findings: Case #1: Lung: Caseous necrosis
* 1.1 Clinical Summary
* 1.2 Autopsy Findings
* 2 External links

## Pathological Findings: Case #1: Lung: Caseous necrosis

[edit | edit source]

### Clinical Summary

[edit | edit source]

A 70-year-old man was admitted to the hospital with a history of upper abdominal pain, anorexia, nausea, and general malaise, all of approximately three weeks' duration. His hospital stay was characterized by fever and severe respiratory distress. There were multiple densities in the patient's chest x-ray consistent with pneumonia and examination of a stained sputum specimen showed acid fast bacilli. Despite intensive therapy, the patient progressively deteriorated and died 14 days after admission.

### Autopsy Findings

[edit | edit source]

It was determined at autopsy that the patient suffered from pulmonary tuberculosis with widespread dissemination throughout the body. The left lung weighed 620 grams and the right lung 1230 grams. These were characterized by marked congestion and edema. In addition, multiple gray-white nodules ranging from pinpoint size up to 1 cm were diffusely distributed throughout the lung parenchyma.

Images courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology

* A gross photograph of a cut section of lung from this patient with disseminated tuberculosis. The numerous small white nodules scattered throughout this lung tissue represent individual tuberculosis granulomas. In addition, note the dark areas throughout the lung which represent deposits of anthracotic pigment.

* This is a closer view of the same section of lung containing multiple white granulomas which are now more easily identified (arrows). These lesions are referred to as miliary tuberculosis. Dark areas of anthracosis are also prominent in this lung.

* This gross photograph shows hilar lymph nodes from another patient with disseminated tuberculosis. The white, cheesy-appearing nodules (arrows) in the lymph nodes give rise to the descriptive terminology of caseous necrosis. The black pigment in the lymph nodes is anthracotic pigment that has drained from the lungs.

* This is a low-power photomicrograph of a histology section from the lung of this patient with a chronic history of respiratory disease. Note the multiple eosinophilic nodules (arrows) seen at low power in this section. Other areas of the lung are relatively normal and several bronchi and large vessels can be seen at this low power. The pleural surface of the lung is at the left and the remaining edges are cut edges of the tissue block.

* This higher-power photomicrograph of the eosinophilic nodules (arrows) illustrates their discreet nature and the surrounding inflammatory response in the remaining normal lung tissue.

* This photomicrograph shows a single nodule with an amorphous eosinophilic center and accumulations of cells around the outer edge. This is typical of a granuloma associated with tuberculosis in which there is a necrotic center (1) and a rim of lymphocytes, macrophages, and occasional multinucleated giant cells around the periphery.

* This is a higher-power view of the granuloma with the amorphous eosinophilic material representing caseation necrosis (1), giant cells near the center (2), and inflammatory cells around the periphery.

* This is a high-power photomicrograph of the Langhans-type multinucleated giant cell which is characteristic of tuberculous granulomas (arrow). Note the horseshoe shape of the nuclei in this giant cell. The majority of the cells in the upper left portion of this section are macrophages which provide the major cellular component in a granuloma. Note the smaller number of small blue-staining cells in the peripheral portions of this granuloma to the left of which are lymphocytes.

## External links

[edit | edit source]

* Microscope images of caseous necrosis
* Image of a hilar lymph node demonstrating caseous necrosis
* Image of a caseating granuloma of tuberculosis in the adrenal gland
* Image of a caseating granuloma

Template:Pathology

Template:WH Template:WS