Cholangiocarcinoma historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  Farima Kahe M.D. [2]

## Overview

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In 1973, Lubana et al reported the first case of primary intrahepatic cholangiocarcinoma with right upper quadrant pain, jaundice, and weight loss.

## Historical Perspective

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### Discovery

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* In 1965, Gerald Kaltskin first described adenocarcinoma of hepatic duct at its bifurcation within porta hepatis. It is called "Kaltskin tumor".[1]
* In 1973, Lubana et al reported the first case of primary intrahepatic cholangiocarcinoma with right upper quadrant pain, jaundice, and weight loss.[2]

## References

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1. ↑ KLATSKIN G (1965). "ADENOCARCINOMA OF THE HEPATIC DUCT AT ITS BIFURCATION WITHIN THE PORTA HEPATIS. AN UNUSUAL TUMOR WITH DISTINCTIVE CLINICAL AND PATHOLOGICAL FEATURES". Am J Med. 38: 241–56. PMID 14256720.
2. ↑ Lubana SS, Singh N, Seligman B, Tuli SS, Heimann DM (2015). "First Reported Case of Primary Intrahepatic Cholangiocarcinoma with Pure Squamous Cell Histology: A Case Report". Am J Case Rep. 16: 438–44. doi:10.12659/AJCR.894609. PMC 4501643. PMID 26158884.

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