Chronic lymphocytic leukemia laboratory tests

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

## Overview

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Laboratory findings consistent with the diagnosis of chronic lymphocytic leukemia include abnormal complete blood count, immunohistochemistry, and electrophoresis. Monoclonality of kappa and lambda producing B cells is a key diagnostic feature among patients with chronic lymphocytic leukemia.[1][2]

## Laboratory Findings

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### Complete Blood Count

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* Absolute lymphocytosis (>5000 cells/μl)[1][2]
* Decreased hemoglobin concentration
* Decreased platelets count

### Blood Smear

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* Presence of smudge cells[1][2]

### Metabolic Panel

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* Elevated low-density lipoprotein level[1][2]

### Quantitative Immunoglobulin Assay

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* Quantitative measurement of IgA, IgG, and IgM immunoglobulins to detect hypogammaglobulinemia[1][2]
* Elevated β2-microglobulin level

### Electrophoresis

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* Monoclonality of kappa and lambda producing B cells is a key diagnostic feature among patients with chronic lymphocytic leukemia.[1][2]

### Immunohistochemistry

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* Chronic lymphocytic leukemia cells typically express CD19, CD20, CD23, and CD5 on the cell surface.[1][2]

## References

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1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 Nabhan C, Rosen ST (2014). "Chronic lymphocytic leukemia: a clinical review". JAMA. 312 (21): 2265–76. doi:10.1001/jama.2014.14553. PMID 25461996.
2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 Chronic Lymphocytic Leukimea. Wikipedia (2015) https://en.wikipedia.org/wiki/B-cell_chronic_lymphocytic_leukemia Accessed on October ,12 2015