Chronic lymphocytic leukemia physical examination

Chronic lymphocytic leukemia Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Chronic lymphocytic leukemia from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Chronic lymphocytic leukemia physical examination On the Web

Most recent articles

cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Chronic lymphocytic leukemia physical examination

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Chronic lymphocytic leukemia physical examination

CDC on Chronic lymphocytic leukemia physical examination

Chronic lymphocytic leukemia physical examination in the news

Blogs on Chronic lymphocytic leukemia physical examination

Directions to Hospitals Treating Chronic lymphocytic leukemia

Risk calculators and risk factors for Chronic lymphocytic leukemia physical examination

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:  Haytham Allaham, M.D. [2]Raviteja Guddeti, M.B.B.S. [3]

## Overview[edit | edit source]

Physical examination of patients with chronic lymphocytic leukemia is usually remarkable for skin pallor, palpable cervical lymph nodes, and hepatomegaly.

## Physical Examination[edit | edit source]

### General Appearance[edit | edit source]

Chronic lymphocytic leukemia patients often appear cachexic with "B" symptoms (5-10%):[1][2][3][4]

* Fever
* Unintentional weight loss
* Muscle wasting
* Generalized weakness/ Fatigue
* Anorexia
* Night sweats

### Skin[edit | edit source]

* Pallor
* Petechiae
* Leukemia cutis (infiltration of neoplastic leukocytes or their precursors into the skin resulting in clinically identifiable cutaneous lesions)[5]

### HEENT[edit | edit source]

* Painless lymph node enlargement (50-90%), usually cervical, supraclavicular, and axillary.
* Dacryoadenitis

### Abdomen[edit | edit source]

* Splenomegaly (25-55%)
* Hepatomegaly (15-25%)

### Images[edit | edit source]

##### Extremity[edit | edit source]

* Leukemia. Adapted from Dermatology Atlas.[6]

##### Trunk[edit | edit source]

* Leukemia. Adapted from Dermatology Atlas.[6]

* Leukemia. Adapted from Dermatology Atlas.[6]

* Leukemia. Adapted from Dermatology Atlas.[6]

## References[edit | edit source]

1. ↑ Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). "iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL". Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.
2. ↑ Hallek M, Cheson BD, Catovsky D, Caligaris-Cappio F, Dighiero G, Döhner H, Hillmen P, Keating M, Montserrat E, Chiorazzi N, Stilgenbauer S, Rai KR, Byrd JC, Eichhorst B, O'Brien S, Robak T, Seymour JF, Kipps TJ (June 2018). "iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL". Blood. 131 (25): 2745–2760. doi:10.1182/blood-2017-09-806398. PMID 29540348.
3. ↑ Rai KR, Sawitsky A, Cronkite EP, Chanana AD, Levy RN, Pasternack BS (August 1975). "Clinical staging of chronic lymphocytic leukemia". Blood. 46 (2): 219–34. PMID 1139039.
4. ↑ Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J, Rai K (January 2017). "Chronic lymphocytic leukaemia". Nat Rev Dis Primers. 3: 16096. doi:10.1038/nrdp.2016.96. PMC 5336551. PMID 28102226.
5. ↑ Agnew KL, Ruchlemer R, Catovsky D, Matutes E, Bunker CB (June 2004). "Cutaneous findings in chronic lymphocytic leukaemia". Br. J. Dermatol. 150 (6): 1129–35. doi:10.1111/j.1365-2133.2004.05982.x. PMID 15214899.
6. ↑ 6.0 6.1 6.2 6.3 "Dermatology Atlas".

Template:Hematology

* v
* t
* e

Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)

CFU-GM/
and other granulocytes|

Template:Navbox subgroup

MEP|

Template:Navbox subgroup

CFU-Mast|

Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)

Multiple/unknown|

AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) * MP (Myelofibrosis) * Acute biphenotypic leukaemia

See also hematology, lymphoid malignancy

Template:WikiDoc Sources
*[v]: View this template
*[t]: Discuss this template
*[e]: Edit this template