Contact Dermatitis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2] Associate Editor(s)-in-Chief:  Saumya Easaw, M.B.B.S.[3]

## Classification[edit | edit source]

There are three types of contact dermatitis: irritant contact, allergic contact, and photocontact dermatitis. Photocontact dermatitis is divided into two categories: phototoxic and photo-allergic.

### Irritant Contact Dermatitis[edit | edit source]

This is the most common form of contact dermatitis. ICD can be caused by either an acute or chronic exposure to a toxic insult. It is caused by either chemical or physical irritants. People who do a lot of wet work (mothers of small children, hairdressers, nurses, chefs) are very prone to developing ICD.

* Chemical irritant contact dermatitis is either acute or chronic, which is usually associated with strong and weak irritants respectively (HSE MS24)[1]. The following definition is provided by Mathias and Maibach (1978):[2] a nonimmunologic local inflammatory reaction characterized by erythema, edema, or corrosion following single or repeated application of a chemical substance to an identical cutaneous site.

The mechanism of action varies between toxins. Detergents, surfactants, extremes of pH, and organic solvents all have the common effect of directly affecting the barrier properties of the epidermis. These effects include removing fat emulsion, inflicting cellular damage on the epithelium, and increasing the transepidermal water loss by damaging the horny layer water-binding mechanisms and damaging the DNA, which causes the layer to thin. Strong concentrations of irritants cause an acute effect, but this is not as common as the accumulative, chronic effect of irritants whose deleterious effects build up with subsequent doses (ESCD 2006). Common chemical irritants implicated include solvents (alcohol, xylene, turpentine, esters, acetone, ketones, and others); metalworking fluids (neat oils, water-based metalworking fluids with surfactants); latex; kerosene; ethylene oxide; surfactants in topical medications and cosmetics (sodium lauryl sulfate);alkalies (drain cleaners, strong soap with lye residues).

* Physical irritant contact dermatitis is a less researched form of ICD (Maurice-Jones et al)[3] due to its various mechanisms of action and a lack of a test for its diagnosis. A complete patient history combined with negative allergic patch testing is usually necessary to reach a correct diagnosis. The simplest form of PICD results from prolonged rubbing, although the diversity of implicated irritants is far wider.[citation needed] Examples include paper friction, fiberglass, and scratchy clothing.

Many plants cause ICD by directly irritating the skin. Some plants act through their spines or irritant hairs. Some plant such as the buttercup, spurge, and daisy act by chemical means. The sap of these plants contains a number of alkaloids, glycosides, saponins, anthroquinones, and (in the case of plant bulbs) irritant calcium oxalate crystals - all of which can cause CICD (Mantle and Lennard, 2001)[4].

### Allergic Contact Dermatitis[edit | edit source]

This condition is the manifestation of an allergic response caused by contact with a substance. A list of common allergens is shown in Table 1 (Kucenic and Belsito, 2002)[5]. Although less common than ICD, ACD is accepted to be the most prevalent form of immunotoxicity found in humans (Kimble et al 2002)[6]. By its allergic nature, this form of contact dermatitis is a hypersensitive reaction that is atypical within the population. The mechanisms by which these reactions occur are complex, with many levels of fine control. Their immunology centres around the interaction of immunoregulatory cytokines and discrete subpopulations of T lymphocytes.

ACD arises as a result of two essential stages: an induction phase, which primes and sensitizes the immune system for an allergic response, and an elicitation phase, in which this response is triggered (Kimble et al 2002). As such, ACD is termed a Type IV delayed hypersensitivity reaction involving a cell-mediated allergic response. Contact allergens are essentially soluble haptens (low in molecular weight) and, as such, have the physico-chemical properties that allow them to cross the stratum corneum of the skin. They can only cause their response as part of a complete antigen, involving their association with epidermal proteins forming hapten-protein conjugates. This, in turn, requires them to be protein-reactive.

The conjugate formed is then recognized as a foreign body by the Langerhans cells (LCs) (and in some cases Dendritic cells (DCs)), which then internalize the protein; transport it via the lymphatic system to the regional lymph nodes; and present the antigen to T-lymphocytes. This process is controlled by cytokines and chemokines - with tumor necrosis factor alpha (TNF-α) and certain members of the interleukin family (1, 13 and 18) - and their action serves either to promote or to inhibit the mobilization and migration of these LCs. (Kimble et al 2002) As the LCs are transported to the lymph nodes, they become differentiated and transform into DCs, which are immunostimulatory in nature.

Once within the lymph glands, the differentiated DCs present the allergenic epitope associated with the allergen to T lymphocytes. These T cells then divide and differentiate, clonally multiplying so that if the allergen is experienced again by the individual, these T cells will respond more quickly and more aggressively. Kimbe et al (2002) explore the complexities of ACD's immunological reaction in short: It appears that there are two major phenotypes of cytokine production (although there exists a gradient of subsets in between), and these are termed T-helper 1 and 2 (Th1 and Th2). Although these cells initially differentiate from a common stem cell, they develop with time as the immune system matures. Th1 phenotypes are characterised by their focus on Interleukin and Interferon, while Th2 cells action is centred more around the regulation of IgE by cytokines. The CD4 and CD8 T lymphocyte subsets also have been found to contribute to differential cytokine regulation, with CD4 having been shown to produce high levels of IL-4 and IL10 while solely CD8 cells are associated with low levels of IFN?. These two cell subtypes are also closely associated with the cell matrix interactions essential for the pathogenesis of ACD.

White et al have suggested that there appears to be a threshold to the mechanisms of allergic sensitisation by ACD-associated allergens (1986). [7] This is thought to be linked to the level at which the toxin induces the up-regulation of the required mandatory cytokines and chemokines. It has also been proposed that the vehicle in which the allergen reaches the skin could take some responsibility in the sensitisation of the epidermis by both assisting the percutaneous penetration and causing some form of trauma and mobilization of cytokines itself.

Common allergens implicated include the following:

* Nickel (nickel sulfate hexahydrate) - metal frequently encountered in jewelry and clasps or buttons on clothing
* Gold (gold sodium thiosulfate) - precious metal often found in jewelry
* Balsam of Peru (Myroxylon pereirae) - a fragrance used in perfumes and skin lotions, derived from tree resin (see also Tolu balsam)
* Thimerosal \- a mercury compound used in local antiseptics and in vaccines
* Neomycin \- a topical antibiotic common in first aid creams and ointments, cosmetics, deodorant, soap and pet food
* Fragrance mix - a group of the eight most common fragrance allergens found in foods, cosmetic products, insecticides, antiseptics, soaps, perfumes and dental products[8]
* Formaldehyde \- a preservative with multiple uses, e.g., in paper products, paints, medications, household cleaners, cosmetic products and fabric finishes
* Cobalt chloride - metal found in medical products; hair dye; antiperspirant; metal-plated objects such as snaps, buttons or tools; and in cobalt blue pigment
* Bacitracin \- a topical antibiotic
* Quaternium-15 \- preservative in cosmetic products (self-tanners, shampoo, nail polish, sunscreen) and in industrial products (polishes, paints and waxes).[9]

### Photocontact Dermatitis[edit | edit source]

Sometimes termed "photoaggravated"(Bourke et al 2001)[10], and divided into two categories, phototoxic and photoallergic, PCD is the eczematous condition which is triggered by an interaction between an otherwise unharmful or less harmful substance on the skin and ultraviolet light (320-400nm UVA) (ESCD 2006), therefore manifesting itself only in regions where the sufferer has been exposed to such rays. Without the presence of these rays, the photosensitiser is not harmful. For this reason, this form of contact dermatitis is usually associated only with areas of skin which are left uncovered by clothing. The mechanism of action varies from toxin to toxin, but is usually due to the production of a photoproduct. Toxins which are associated with PCD include the psoralens. Psoralens are in fact used therapeutically for the treatment of psoriasis, eczema and vitiligo. Photocontact dermatitis is another condition where the distinction between forms of contact dermatitis is not clear cut. Immunological mechanisms can also play a part, causing a response similar to ACD.

## References[edit | edit source]

1. ↑ HSE Guidance Notes. Guidance Note MS 24 - Health Surveillance of occupational skin disease. http://www.hse.gov.uk/pubns/ms24.pdf
2. ↑ Mathias CG, Maibach HI. Dermatotoxicology monographs I. Cutaneous irritation: factors influencing the response to irritants. Clin Toxicol. 1978;13(3):333-46. Review. No abstract available.
3. ↑ Morris-Jones R, Robertson SJ, Ross JS, White IR, McFadden JP, Rycroft RJ. Dermatitis caused by physical irritants. Br J Dermatol. 2002 Aug;147(2):270- 5. Review.
4. ↑ Mantle D, Lennard TWJ. Plants and the skin. Brit J Derm Nurs. 2001 (Summer).
5. ↑ Kucenic MJ, Belsito DV.Occupational allergic contact dermatitis is more prevalent than irritant contact dermatitis: a 5-year study. J Am Acad Dermatol. 2002 May;46(5):695-9.
6. ↑ Kimble I, Basketter DA, Gerberick GF, Dearman RJ. Allergic contact dermatitis. Int Immunopharmacol. 2002 Feb;2(2-3):201-11. Review.
7. ↑ White SI, Friedmann PS, Moss C, Simpson JM.The effect of altering area of application and dose per unit area on sensitization by DNCB. Br J Dermatol. 1986 Dec;115(6):663-8.
8. ↑ Allergy to fragrance mix at DermNetNZ, http://dermnetnz.org/dermatitis/fragrance-allergy.html
9. ↑ Mayo Clinic study, http://http://www.mayoclinic.org/news2006-rst/3268.html
10. ↑ Bourke J, Coulson I, English J; British Association of Dermatologists. Guidelines for care of contact dermatitis. Br J Dermatol. 2001 Dec;145(6):877-85.

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