Copper aspirinate

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Copper(II) aspirinate is an aspirin chelate of copper(II) cations (Cu2+). It is used to treat rheumatoid arthritis.

## Contents

* 1 Preparation
* 2 Medicinal Use
* 3 Other Uses
* 4 External Links
* 5 Footnotes

## Preparation

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Copper aspirinate can be prepared by several methods. In one route of preparation, an excess of acetylsalicylic acid is dissolved in aqueous sodium carbonate. Sodium hydroxide is not suitable for this purpose, because it will hydrolyse acetylsalicylic acid (ASA) into salicylic acid and sodium acetate.

2 HC9H7O4 \+ Na2CO3 → 2 NaC9H7O4 \+ CO2↑ + H2O

The resulting solution is then filtered to remove any undissolved acetylsalicylic acid and is mixed with a solution containing Cu2+ cations (copper(II) sulfate is suitable), precipitating bright blue crystals of copper aspirinate immediately. The crystals can then be filtered from solution, washed, and recrystallized. An excess of acetylsalicylic acid is used in the first step, because it eliminates the possibility of unreacted carbonate anions precipitating the copper in this step.

4 NaC9H7O4 \+ 2 CuSO4 → C36H28Cu2O16↓ + 2 Na2SO4

## Medicinal Use

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Copper aspirinate has been proven effective as a treatment for rheumatoid arthritis.[1]

## Other Uses

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The use of copper aspirinate as a pigment in PVC and Polystyrene has also been investigated. [2]

## External Links

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* IR Spectrum from Eckerd College's Chem Department

## Footnotes

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1. ↑ "Rheumatoid Arthritis (RA)". Copper Development Association. June 2000.
2. ↑ Allan, J R (1991). "A Study of the Performance of Bis(acetylsalicylate) Copper(II) and the Cobalt(II), Nickel(II) and Copper(II) Complexes of Pyridine-3,4-dicarboxylic Acid as Colouring Materials for Poly(vinyl chloride) and Polystyrene". Eur. Polym. J. 27 (7): 669–672. Unknown parameter `|coauthors=` ignored (help); line feed character in `|title=` at position 71 (help)