EDG1

Endothelial differentiation, sphingolipid G-protein-coupled receptor, 1

Identifiers
Symbols|  EDG1 ; ECGF1; CHEDG1; D1S3362; EDG-1; S1PR1
External IDs|  Template:OMIM5 Template:MGI HomoloGene: 1071
| Gene ontology

Molecular function | Template:GNF GO Template:GNF GO
Cellular component | Template:GNF GO Template:GNF GO
Biological process | Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species|  Human|  Mouse
Entrez|  n/a|  n/a
Ensembl|  n/a|  n/a
UniProt|  n/a|  n/a
RefSeq (mRNA)|  n/a|  n/a
RefSeq (protein)|  n/a|  n/a
Location (UCSC)|  n/a|  n/a
PubMed search|  n/a|  n/a

EDG1 (endothelial differentiation gene 1) is a human gene which encodes a G-protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P1.

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion.[1]

## Contents

* 1 See also
* 2 References
* 3 Further reading
* 4 External links

## See also

[edit | edit source]

* Lysophospholipid receptor

## References

[edit | edit source]

1. ↑ "Entrez Gene: EDG1 endothelial differentiation, sphingolipid G-protein-coupled receptor, 1".

## Further reading

[edit | edit source]

* Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci. 905: 54–60. PMID 10818441.
* Igarashi Y (2002). "[Current studies on a novel lipid mediator, sphingosine 1-phosphate, and its receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 476–9. PMID 11915345.
* Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso. 47 (4 Suppl): 496–502. PMID 11915348.
* Takuwa Y, Takuwa N, Sugimoto N (2003). "The Edg family G protein-coupled receptors for lysophospholipids: their signaling properties and biological activities". J. Biochem. 131 (6): 767–71. PMID 12038970.CS1 maint: Multiple names: authors list (link)
* Hla T, Maciag T (1990). "An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors". J. Biol. Chem. 265 (16): 9308–13. PMID 2160972.
* Lee MJ, Evans M, Hla T (1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". J. Biol. Chem. 271 (19): 11272–9. PMID 8626678.CS1 maint: Multiple names: authors list (link)
* Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.CS1 maint: Multiple names: authors list (link)
* An S, Bleu T, Huang W; et al. (1998). "Identification of cDNAs encoding two G protein-coupled receptors for lysosphingolipids". FEBS Lett. 417 (3): 279–82. PMID 9409733.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lee MJ, Van Brocklyn JR, Thangada S; et al. (1998). "Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1". Science. 279 (5356): 1552–5. PMID 9488656.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lee MJ, Thangada S, Liu CH; et al. (1998). "Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist". J. Biol. Chem. 273 (34): 22105–12. PMID 9705355.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Ancellin N, Hla T (1999). "Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5". J. Biol. Chem. 274 (27): 18997–9002. PMID 10383399.
* Windh RT, Lee MJ, Hla T; et al. (1999). "Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins". J. Biol. Chem. 274 (39): 27351–8. PMID 10488065.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lee MJ, Thangada S, Claffey KP; et al. (1999). "Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate". Cell. 99 (3): 301–12. PMID 10555146.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Igarashi J, Michel T (2000). "Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction". J. Biol. Chem. 275 (41): 32363–70. doi:10.1074/jbc.M003075200. PMID 10921915.
* Parrill AL, Wang D, Bautista DL; et al. (2001). "Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate". J. Biol. Chem. 275 (50): 39379–84. doi:10.1074/jbc.M007680200. PMID 10982820.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Liu Y, Wada R, Yamashita T; et al. (2000). "Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation". J. Clin. Invest. 106 (8): 951–61. PMID 11032855.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Murphy WJ, Eizirik E, Johnson WE; et al. (2001). "Molecular phylogenetics and the origins of placental mammals". Nature. 409 (6820): 614–8. doi:10.1038/35054550. PMID 11214319.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Hobson JP, Rosenfeldt HM, Barak LS; et al. (2001). "Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility". Science. 291 (5509): 1800–3. doi:10.1126/science.1057559. PMID 11230698.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Lee MJ, Thangada S, Paik JH; et al. (2001). "Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis". Mol. Cell. 8 (3): 693–704. PMID 11583630.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

## External links

[edit | edit source]

* IUPHAR GPCR Database - Lysophospholipid receptors
* Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

| Neurotransmitter|

| Adrenergic|

* α1 (A
* B
* D)
* α2 (A
* B
* C)
* β1
* β2
* β3

|

Purinergic|

* Adenosine (A1
* A2A
* A2B
* A3)
* P2Y (1
* 2
* 4
* 5
* 6
* 8
* 9
* 10
* 11
* 12
* 13
* 14)

Serotonin|

* (all but 5-HT3) 5-HT1 (A
* B
* D
* E
* F)
* 5-HT2 (A
* B
* C)
* 5-HT (4
* 5A
* 6
* 7)

Other|

* Acetylcholine (M1
* M2
* M3
* M4
* M5)
* Dopamine
* D1
* D2
* D3
* D4
* D5
* GHB receptor
* Histamine
* H1
* H2
* H3
* H4
* Melatonin (1A
* 1B
* 1C)
* TAAR (1
* 2
* 5
* 6
* 8
* 9)

Metabolites and
signaling molecules|

| Eicosanoid|

* CysLT (1
* 2)
* LTB4
* 1
* 2
* FPRL1
* OXE
* Prostaglandin
* DP (1
* 2), EP (1
* 2
* 3
* 4), FP
* Prostacyclin
* Thromboxane

|

Other|

* Bile acid
* Cannabinoid (CB1
* CB2, GPR (18
* 55
* 119))
* EBI2
* Estrogen
* Free fatty acid (1
* 2
* 3
* 4)
* Hydroxycarboxylic acids
* 1
* 2
* 3
* Lysophosphatidic acid (1
* 2
* 3
* 4
* 5
* 6)
* Lysophospholipid (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8)
* Oxoglutarate
* PAF
* Sphingosine-1-phosphate (1
* 2
* 3
* 4
* 5)
* Succinate

Peptide|

| Neuropeptide|

* B/W (1
* 2)
* FF (1
* 2)
* S
* Y (1
* 2
* 4
* 5)
* Neuromedin (B
* U (1
* 2))
* Neurotensin (1
* 2)

|

Other|

* Anaphylatoxin (C3a
* C5a)
* Angiotensin (1
* 2)
* Apelin
* Bombesin
* BRS3
* GRPR
* NMBR)
* Bradykinin (B1
* B2)
* Chemokine
* Cholecystokinin (A
* B)
* Endothelin
* A
* B
* Formyl peptide (1
* 2
* 3)
* FSH
* Galanin (1
* 2
* 3)
* Gonadotropin-releasing hormone (1
* 2)
* Ghrelin
* Kisspeptin
* Luteinizing hormone/choriogonadotropin
* MAS (1
* 1L
* D
* E
* F
* G
* X1
* X2
* X3
* X4)
* Melanocortin (1
* 2
* 3
* 4
* 5)
* MCHR (1
* 2)
* Motilin
* Opioid (Delta
* Kappa
* Mu
* Nociceptin & Zeta, but not Sigma)
* Orexin (1
* 2)
* Oxytocin
* Prokineticin (1
* 2)
* Prolactin-releasing peptide
* Relaxin (1
* 2
* 3
* 4)
* Somatostatin (1
* 2
* 3
* 4
* 5)
* Tachykinin (1
* 2
* 3)
* Thyrotropin
* Thyrotropin-releasing hormone
* Urotensin-II
* Vasopressin (1A
* 1B
* 2)

Miscellaneous|

| Orphan|

* GPR (1
* 3
* 4
* 6
* 12
* 15
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 25
* 26
* 27
* 31
* 32
* 33
* 34
* 35
* 37
* 39
* 42
* 44
* 45
* 50
* 52
* 55
* 61
* 62
* 63
* 65
* 68
* 75
* 77
* 78
* 81
* 82
* 83
* 84
* 85
* 87
* 88
* 92
* 101
* 103
* 109A
* 109B
* 119
* 120
* 132
* 135
* 137B
* 139
* 141
* 142
* 146
* 148
* 149
* 150
* 151
* 152
* 153
* 160
* 161
* 162
* 171
* 173
* 174
* 176
* 177
* 182
* 183)

|

Other|

* Adrenomedullin
* Olfactory
* Opsin (3
* 4
* 5
* 1LW
* 1MW
* 1SW
* RGR
* RRH)
* Protease-activated (1
* 2
* 3
* 4)
* SREB (1
* 2
* 3)

Class B: Secretin-like

| Adhesion|

* ADGRG (1
* 2
* 3
* 4
* 5
* 6
* 7)

|

Orphan|

* GPR (56
* 64
* 97
* 98
* 110
* 111
* 112
* 113
* 114
* 115
* 116
* 123
* 124
* 125
* 126
* 128
* 133
* 143
* 144
* 155
* 157)

Other|

* Brain-specific angiogenesis inhibitor (1
* 2
* 3)
* Cadherin (1
* 2
* 3)
* Calcitonin
* CALCRL
* CD97
* Corticotropin-releasing hormone (1
* 2)
* EMR (1
* 2
* 3)
* Glucagon (GR
* GIPR
* GLP1R
* GLP2R)
* Growth-hormone-releasing hormone
* PACAPR1
* GPR
* Latrophilin (1
* 2
* 3
* ELTD1)
* Methuselah-like proteins
* Parathyroid hormone (1
* 2)
* Secretin
* Vasoactive intestinal peptide (1
* 2)

Class C: Metabotropic glutamate / pheromone

| Taste|

* TAS1R (1
* 2
* 3)
* TAS2R (1
* 3
* 4
* 5
* 7
* 8
* 9
* 10
* 13
* 14
* 16
* 19
* 20
* 30
* 31
* 38
* 39
* 40
* 41
* 42
* 43
* 45
* 46
* 50
* 60
* Vomeronasal receptor)

|

Other|

* Calcium-sensing receptor
* GABAB (1
* 2)
* Glutamate receptor (Metabotropic glutamate (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8))
* GPRC6A
* GPR (156
* 158
* 179)
* RAIG (1
* 2
* 3
* 4)

Class F: Frizzled & Smoothened

| Frizzled|

* Frizzled (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10)

|

Smoothened|

* Smoothened

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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