EDG2

Endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2

Identifiers
Symbols|  EDG2 ; Gpcr26; LPA1; LPAR1; Mrec1.3; edg-2; rec.1.3; vzg-1
External IDs|  Template:OMIM5 Template:MGI HomoloGene: 1072
| Gene ontology

Molecular function | Template:GNF GO Template:GNF GO
Cellular component | Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
Biological process | Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species|  Human|  Mouse
Entrez|  n/a|  n/a
Ensembl|  n/a|  n/a
UniProt|  n/a|  n/a
RefSeq (mRNA)|  n/a|  n/a
RefSeq (protein)|  n/a|  n/a
Location (UCSC)|  n/a|  n/a
PubMed search|  n/a|  n/a

EDG2 (endothelial differentiation gene 2) is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule lysophosphatidic acid (LPA). Hence this receptor is also known as LPA1.[1]

The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Alternative splicing of this gene has been observed and two transcript variants have been described, each encoding identical proteins. An alternate translation start codon has been identified, which results in isoforms differing in the N-terminal extracellular tail. In addition, an alternate polyadenylation site has been reported.[1]

## Contents

* 1 See also
* 2 References
* 3 Further reading
* 4 External links

## See also

[edit | edit source]

* Lysophospholipid receptor

## References

[edit | edit source]

1. ↑ 1.0 1.1 "Entrez Gene: EDG2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2".

## Further reading

[edit | edit source]

* An S, Goetzl EJ, Lee H (1999). "Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate". J. Cell. Biochem. Suppl. 30-31: 147–57. PMID 9893266.CS1 maint: Multiple names: authors list (link)
* Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors". Mol. Pharmacol. 58 (6): 1188–96. PMID 11093753.CS1 maint: Multiple names: authors list (link)
* Hecht JH, Weiner JA, Post SR, Chun J (1997). "Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex". J. Cell Biol. 135 (4): 1071–83. PMID 8922387.CS1 maint: Multiple names: authors list (link)
* Moolenaar WH, Kranenburg O, Postma FR, Zondag GC (1997). "Lysophosphatidic acid: G-protein signalling and cellular responses". Curr. Opin. Cell Biol. 9 (2): 168–73. PMID 9069262.CS1 maint: Multiple names: authors list (link)
* An S, Dickens MA, Bleu T; et al. (1997). "Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid". Biochem. Biophys. Res. Commun. 231 (3): 619–22. doi:10.1006/bbrc.1997.6150. PMID 9070858.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Fukushima N, Kimura Y, Chun J (1998). "A single receptor encoded by vzg-1/lpA1/edg-2 couples to G proteins and mediates multiple cellular responses to lysophosphatidic acid". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6151–6. PMID 9600933.CS1 maint: Multiple names: authors list (link)
* An S, Bleu T, Zheng Y, Goetzl EJ (1998). "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. PMID 9804623.CS1 maint: Multiple names: authors list (link)
* Cervera P, Tirard M, Barron S; et al. (2002). "Immunohistological localization of the myelinating cell-specific receptor LP(A1)". Glia. 38 (2): 126–36. PMID 11948806.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Hama K, Bandoh K, Kakehi Y; et al. (2002). "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors". FEBS Lett. 523 (1–3): 187–92. PMID 12123830.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Van Leeuwen FN, Olivo C, Grivell S; et al. (2003). "Rac activation by lysophosphatidic acid LPA1 receptors through the guanine nucleotide exchange factor Tiam1". J. Biol. Chem. 278 (1): 400–6. doi:10.1074/jbc.M210151200. PMID 12393875.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Murph MM, Scaccia LA, Volpicelli LA, Radhakrishna H (2004). "Agonist-induced endocytosis of lysophosphatidic acid-coupled LPA1/EDG-2 receptors via a dynamin2- and Rab5-dependent pathway". J. Cell. Sci. 116 (Pt 10): 1969–80. doi:10.1242/jcs.00397. PMID 12668728.CS1 maint: Multiple names: authors list (link)
* Shida D, Kitayama J, Yamaguchi H; et al. (2003). "Lysophosphatidic acid (LPA) enhances the metastatic potential of human colon carcinoma DLD1 cells through LPA1". Cancer Res. 63 (7): 1706–11. PMID 12670925.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Matsuda A, Suzuki Y, Honda G; et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID 12761501.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Xu J, Lai YJ, Lin WC, Lin FT (2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. 279 (11): 10459–68. doi:10.1074/jbc.M311891200. PMID 14688263.CS1 maint: Multiple names: authors list (link)
* Komuro Y, Watanabe T, Kitayama J; et al. (2004). "The Immunohistochemical expression of endothelial cell differentiation gene-2 receptor in human colorectal adenomas". Hepatogastroenterology. 50 (54): 1770–3. PMID 14696401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
* Kaneider NC, Lindner J, Feistritzer C; et al. (2005). "The immune modulator FTY720 targets sphingosine-kinase-dependent migration of human monocytes in response to amyloid beta-protein and its precursor". FASEB J. 18 (11): 1309–11. doi:10.1096/fj.03-1050fje. PMID 15208267.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

## External links

[edit | edit source]

* IUPHAR GPCR Database - Lysophospholipid receptors
* Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

* v
* t
* e

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

| Neurotransmitter|

| Adrenergic|

* α1 (A
* B
* D)
* α2 (A
* B
* C)
* β1
* β2
* β3

|

Purinergic|

* Adenosine (A1
* A2A
* A2B
* A3)
* P2Y (1
* 2
* 4
* 5
* 6
* 8
* 9
* 10
* 11
* 12
* 13
* 14)

Serotonin|

* (all but 5-HT3) 5-HT1 (A
* B
* D
* E
* F)
* 5-HT2 (A
* B
* C)
* 5-HT (4
* 5A
* 6
* 7)

Other|

* Acetylcholine (M1
* M2
* M3
* M4
* M5)
* Dopamine
* D1
* D2
* D3
* D4
* D5
* GHB receptor
* Histamine
* H1
* H2
* H3
* H4
* Melatonin (1A
* 1B
* 1C)
* TAAR (1
* 2
* 5
* 6
* 8
* 9)

Metabolites and
signaling molecules|

| Eicosanoid|

* CysLT (1
* 2)
* LTB4
* 1
* 2
* FPRL1
* OXE
* Prostaglandin
* DP (1
* 2), EP (1
* 2
* 3
* 4), FP
* Prostacyclin
* Thromboxane

|

Other|

* Bile acid
* Cannabinoid (CB1
* CB2, GPR (18
* 55
* 119))
* EBI2
* Estrogen
* Free fatty acid (1
* 2
* 3
* 4)
* Hydroxycarboxylic acids
* 1
* 2
* 3
* Lysophosphatidic acid (1
* 2
* 3
* 4
* 5
* 6)
* Lysophospholipid (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8)
* Oxoglutarate
* PAF
* Sphingosine-1-phosphate (1
* 2
* 3
* 4
* 5)
* Succinate

Peptide|

| Neuropeptide|

* B/W (1
* 2)
* FF (1
* 2)
* S
* Y (1
* 2
* 4
* 5)
* Neuromedin (B
* U (1
* 2))
* Neurotensin (1
* 2)

|

Other|

* Anaphylatoxin (C3a
* C5a)
* Angiotensin (1
* 2)
* Apelin
* Bombesin
* BRS3
* GRPR
* NMBR)
* Bradykinin (B1
* B2)
* Chemokine
* Cholecystokinin (A
* B)
* Endothelin
* A
* B
* Formyl peptide (1
* 2
* 3)
* FSH
* Galanin (1
* 2
* 3)
* Gonadotropin-releasing hormone (1
* 2)
* Ghrelin
* Kisspeptin
* Luteinizing hormone/choriogonadotropin
* MAS (1
* 1L
* D
* E
* F
* G
* X1
* X2
* X3
* X4)
* Melanocortin (1
* 2
* 3
* 4
* 5)
* MCHR (1
* 2)
* Motilin
* Opioid (Delta
* Kappa
* Mu
* Nociceptin & Zeta, but not Sigma)
* Orexin (1
* 2)
* Oxytocin
* Prokineticin (1
* 2)
* Prolactin-releasing peptide
* Relaxin (1
* 2
* 3
* 4)
* Somatostatin (1
* 2
* 3
* 4
* 5)
* Tachykinin (1
* 2
* 3)
* Thyrotropin
* Thyrotropin-releasing hormone
* Urotensin-II
* Vasopressin (1A
* 1B
* 2)

Miscellaneous|

| Orphan|

* GPR (1
* 3
* 4
* 6
* 12
* 15
* 17
* 18
* 19
* 20
* 21
* 22
* 23
* 25
* 26
* 27
* 31
* 32
* 33
* 34
* 35
* 37
* 39
* 42
* 44
* 45
* 50
* 52
* 55
* 61
* 62
* 63
* 65
* 68
* 75
* 77
* 78
* 81
* 82
* 83
* 84
* 85
* 87
* 88
* 92
* 101
* 103
* 109A
* 109B
* 119
* 120
* 132
* 135
* 137B
* 139
* 141
* 142
* 146
* 148
* 149
* 150
* 151
* 152
* 153
* 160
* 161
* 162
* 171
* 173
* 174
* 176
* 177
* 182
* 183)

|

Other|

* Adrenomedullin
* Olfactory
* Opsin (3
* 4
* 5
* 1LW
* 1MW
* 1SW
* RGR
* RRH)
* Protease-activated (1
* 2
* 3
* 4)
* SREB (1
* 2
* 3)

Class B: Secretin-like

| Adhesion|

* ADGRG (1
* 2
* 3
* 4
* 5
* 6
* 7)

|

Orphan|

* GPR (56
* 64
* 97
* 98
* 110
* 111
* 112
* 113
* 114
* 115
* 116
* 123
* 124
* 125
* 126
* 128
* 133
* 143
* 144
* 155
* 157)

Other|

* Brain-specific angiogenesis inhibitor (1
* 2
* 3)
* Cadherin (1
* 2
* 3)
* Calcitonin
* CALCRL
* CD97
* Corticotropin-releasing hormone (1
* 2)
* EMR (1
* 2
* 3)
* Glucagon (GR
* GIPR
* GLP1R
* GLP2R)
* Growth-hormone-releasing hormone
* PACAPR1
* GPR
* Latrophilin (1
* 2
* 3
* ELTD1)
* Methuselah-like proteins
* Parathyroid hormone (1
* 2)
* Secretin
* Vasoactive intestinal peptide (1
* 2)

Class C: Metabotropic glutamate / pheromone

| Taste|

* TAS1R (1
* 2
* 3)
* TAS2R (1
* 3
* 4
* 5
* 7
* 8
* 9
* 10
* 13
* 14
* 16
* 19
* 20
* 30
* 31
* 38
* 39
* 40
* 41
* 42
* 43
* 45
* 46
* 50
* 60
* Vomeronasal receptor)

|

Other|

* Calcium-sensing receptor
* GABAB (1
* 2)
* Glutamate receptor (Metabotropic glutamate (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8))
* GPRC6A
* GPR (156
* 158
* 179)
* RAIG (1
* 2
* 3
* 4)

Class F: Frizzled & Smoothened

| Frizzled|

* Frizzled (1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* 10)

|

Smoothened|

* Smoothened

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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