Esophagitis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:  Ajay Gade MD[2]]

## Overview[edit | edit source]

Common risk factors in the development of esophagitis are immunosuppression, alcohol use, smoking, excessive vomiting, certain medications, and surgery or radiation to the chest.

## Risk Factors[edit | edit source]

### Eosinophilic Esophagitis[edit | edit source]

Common risk factors in the development of EoE include:[1][2][3][4][5][6]

* Age- EoE has a bimodal age distribution common in both children and adults.
* Sex- Males are more prone to EoE than the females.
* Weather- Cold and dry climate trigger EoE.
* Location- EoE is common in people with a history of European ancestry.
* Season- Summer and fall, this is because people stay outdoors during this time and the higher levels of the pollen and the other allergens during these seasons.
* Family history- EoE runs in the family and it is more common in people with a positive family history of the EoE.
* History of allergies- EoE is very common in patient with a history of allergies such as asthma, industrial exposures, environmental allergies, chronic respiratory disease, food allergies and atopic dermatitis.

### Reflux Esophagitis[edit | edit source]

Common risk factors in the development of reflux esophagitis include:

* Smoking
* Obesity
* Pregnancy
* Hiatal hernia
* Scleroderma
* Alcohol consumption
* Consuming drinks that contain caffeine

* Medications:

* Anticholinergics (e.g. for seasickness)
* Beta blockers for high blood pressure or heart disease
* Bronchodilators for asthma
* Calcium channel blockers for high blood pressure
* Dopamine-active drugs for Parkinson's disease
* Progestin for abnormal menstrual bleeding or birth control
* Sedatives for insomnia or anxiety
* Tricyclic antidepressants

## References[edit | edit source]

1. ↑ "Genetic dissection of eosinophilic esophagitis provides insight into disease pathogenesis and treatment strategies. - PubMed - NCBI".
2. ↑ "www.ncbi.nlm.nih.gov" (PDF).
3. ↑ "Genetics of Eosinophilic Esophagitis - FullText - Digestive Diseases 2014, Vol. 32, No. 1-2 - Karger Publishers".
4. ↑ Furuta GT, Katzka DA (2015). "Eosinophilic Esophagitis". N. Engl. J. Med. 373 (17): 1640–8. doi:10.1056/NEJMra1502863. PMC 4905697. PMID 26488694.
5. ↑ Kocsis D, Tulassay Z, Juhász M (2015). "[Dietary and pharmacological aspects of eosinophilic esophagitis]". Orv Hetil (in Hungarian). 156 (23): 927–32. doi:10.1556/650.2015.30164. PMID 26027600.CS1 maint: Unrecognized language (link)
6. ↑ Jarosz M, Taraszewska A (2014). "Risk factors for gastroesophageal reflux disease: the role of diet". Prz Gastroenterol. 9 (5): 297–301. doi:10.5114/pg.2014.46166. PMC 4223119. PMID 25396005.

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