Estrone

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Estrone

Clinical data
ATC code|

* G03CA07 (WHO) G03CC04 (WHO)

Pharmacokinetic data
Protein binding| >95%
Elimination half-life| 19 hours
Identifiers

IUPAC name

* 3-hydroxy-13-methyl- 6,7,8,9,11,12,13,14,15,16- decahydrocyclopenta[a]phenanthren- 17- one

CAS Number|

* 53-16-7

PubChem CID|

* 5870

DrugBank|

* APRD00588

E number| {{#property:P628}}
ECHA InfoCard| {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula| C18H22O2
Molar mass| 270.366 g/mol
Melting point| 254.5 °C (490.1 °F)

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List of terms related to Estrone

Estrone (also oestrone) is an estrogenic hormone secreted by the ovary.

Estrone is one of the three estrogens, which also include estriol and estradiol. Estrone is the least prevalent of the three hormones, estradiol being prevalent almost always in a female body, estriol being prevalent primarily during pregnancy. Estrone is relevant to health and disease due to its conversion to estrone sulfate, a long-lived derivative of estrone. Estrone sulfate acts as a pool of estrone which can be converted as needed to the more active estradiol.

## Synthesis

[edit | edit source]

Estrone is synthesized via aromatase from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol.

## Additional images

[edit | edit source]

* Androstenedione converting to estrone.

* Steroidogenesis

Template:Sex hormones

Template:WikiDoc Sources
*[CID]: Compound ID