GRB14

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Identifiers
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External IDs| GeneCards: [1]
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Wikidata
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Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.[1][2]

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.[2]

## Interactions

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GRB14 has been shown to interact with Epidermal growth factor receptor,[3] Fibroblast growth factor receptor 1[4] and TNKS2.[5]

## References

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1. ↑ Baker E, Sutherland GR, Sutherland RL, Daly RJ (February 1997). "Assignment of the human GRB14 gene to chromosome 2q22-q24 by fluorescence in situ hybridization". Genomics. 36 (1): 218–220. doi:10.1006/geno.1996.0453. PMID 8812444.
2. ↑ 2.0 2.1 "Entrez Gene: GRB14 growth factor receptor-bound protein 14".
3. ↑ Daly, R J; Sanderson G M; Janes P W; Sutherland R L (May 1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. UNITED STATES. 271 (21): 12502–12510. doi:10.1074/jbc.271.21.12502. ISSN 0021-9258. PMID 8647858.
4. ↑ Reilly, J F; Mickey G; Maher P A (March 2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. UNITED STATES. 275 (11): 7771–7778. doi:10.1074/jbc.275.11.7771. ISSN 0021-9258. PMID 10713090.
5. ↑ Lyons, R J; Deane R; Lynch D K; Ye Z S; Sanderson G M; Eyre H J; Sutherland G R; Daly R J (May 2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. United States. 276 (20): 17172–17180. doi:10.1074/jbc.M009756200. ISSN 0021-9258. PMID 11278563.

## Further reading

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* Han DC, Shen TL, Guan JL (2001). "The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions". Oncogene. 20 (44): 6315–6321. doi:10.1038/sj.onc.1204775. PMID 11607834.
* Daly RJ, Sanderson GM, Janes PW, Sutherland RL (1996). "Cloning and characterization of GRB14, a novel member of the GRB7 gene family". J. Biol. Chem. 271 (21): 12502–12510. doi:10.1074/jbc.271.21.12502. PMID 8647858.
* Kasus-Jacobi A, Perdereau D, Auzan C, et al. (1998). "Identification of the rat adapter Grb14 as an inhibitor of insulin actions". J. Biol. Chem. 273 (40): 26026–26035. doi:10.1074/jbc.273.40.26026. PMID 9748281.
* Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration". J. Biol. Chem. 274 (43): 30896–30905. doi:10.1074/jbc.274.43.30896. PMID 10521483.
* Reilly JF, Mickey G, Maher PA (2000). "Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner". J. Biol. Chem. 275 (11): 7771–7778. doi:10.1074/jbc.275.11.7771. PMID 10713090.
* Hemming R, Agatep R, Badiani K, et al. (2001). "Human growth factor receptor bound 14 binds the activated insulin receptor and alters the insulin-stimulated tyrosine phosphorylation levels of multiple proteins". Biochem. Cell Biol. 79 (1): 21–32. doi:10.1139/bcb-79-1-21. PMID 11235915.
* Lyons RJ, Deane R, Lynch DK, et al. (2001). "Identification of a novel human tankyrase through its interaction with the adaptor protein Grb14". J. Biol. Chem. 276 (20): 17172–17180. doi:10.1074/jbc.M009756200. PMID 11278563.
* Béréziat V, Kasus-Jacobi A, Perdereau D, et al. (2002). "Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14". J. Biol. Chem. 277 (7): 4845–4852. doi:10.1074/jbc.M106574200. PMID 11726652.
* Cariou B, Perdereau D, Cailliau K, et al. (2002). "The adapter protein ZIP binds Grb14 and regulates its inhibitory action on insulin signaling by recruiting protein kinase Czeta". Mol. Cell. Biol. 22 (20): 6959–6970. doi:10.1128/MCB.22.20.6959-6970.2002. PMC 139806. PMID 12242277.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* King CC, Newton AC (2004). "The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1". J. Biol. Chem. 279 (36): 37518–37527. doi:10.1074/jbc.M405340200. PMID 15210700.
* Scharf PJ, Witney J, Daly R, Lyons BA (2005). "Solution structure of the human Grb14-SH2 domain and comparison with the structures of the human Grb7-SH2/erbB2 peptide complex and human Grb10-SH2 domain". Protein Sci. 13 (9): 2541–2546. doi:10.1110/ps.04884704. PMC 2280013. PMID 15322292.
* Kairouz R, Parmar J, Lyons RJ, et al. (2005). "Hormonal regulation of the Grb14 signal modulator and its role in cell cycle progression of MCF-7 human breast cancer cells". J. Cell. Physiol. 203 (1): 85–93. doi:10.1002/jcp.20199. PMID 15372466.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Depetris RS, Hu J, Gimpelevich I, et al. (2006). "Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14". Mol. Cell. 20 (2): 325–333. doi:10.1016/j.molcel.2005.09.001. PMID 16246733.
* Park JJ, Berggren JR, Hulver MW, et al. (2006). "GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle". Physiol. Genomics. 27 (2): 114–121. doi:10.1152/physiolgenomics.00045.2006. PMID 16849634.

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PDB gallery

* 2aug: Crystal structure of the Grb14 SH2 domain

2aug: Crystal structure of the Grb14 SH2 domain

* 2auh: Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase

2auh: Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase

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