Gallamine

Clinical data
Trade names| Flaxedil
AHFS/Drugs.com| International Drug Names
ATC code|

* M03AC02 (WHO)

Identifiers

IUPAC name

* 2,2’,2’’-[benzene-1,2,3-triyltris(oxy)]tris(N,N,N-triethylethanaminium) triiodide

CAS Number|

* 65-29-2 Y

PubChem CID|

* 6172

IUPHAR/BPS|

* 356

DrugBank|

* DB00483 Y

ChemSpider|

* 5937 N

UNII|

* Q3254X40X2

KEGG|

* D02292 Y

ChEBI|

* CHEBI:503442 Y

ChEMBL|

* ChEMBL1200993 N

E number| {{#property:P628}}
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Chemical and physical data
Formula| C30H60N3O3+3 · 3 I− (gallamine triethiodide)
C24H45N3O3 (gallamine)
Molar mass| 891.529 g/mol (gallamine triethiodide)
423.633 g/mol
(gallamine)
3D model (JSmol)|

* Interactive image

SMILES

* [I-].[I-].[I-].O(c1c(OCC[N+](CC)(CC)CC)cccc1OCC[N+](CC)(CC)CC)CC[N+](CC)(CC)CC

InChI

* InChI=1S/C24H45N3O3/c1-7-25(8-2)16-19-28-22-14-13-15-23(29-20-17-26(9-3)10-4)24(22)30-21-18-27(11-5)12-6/h13-15H,7-12,16-21H2,1-6H3 Y

* Key:ICLWTJIMXVISSR-UHFFFAOYSA-N Y

NY (what is this?) (verify)

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List of terms related to Gallamine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

[edit | edit source]

Gallamine triethiodide (Flaxedil) is a non-depolarising muscle relaxant.[1] It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine.[2] Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia[3][4] and occasionally hypertension. Very high doses cause histamine release.

Gallamine triethiodide is commonly used to stabilize muscle contractions during surgical procedures.

It was developed by Daniel Bovet in 1947.[5]

The pharmaceutical is no longer marketed in the United States, according to the FDA Orange Book.

## References

[edit | edit source]

1. ↑ "Webster's Online Dictionary - Flaxedil". Retrieved 2008-12-15.
2. ↑ "RxMed: Pharmaceutical Information - FLAXEDIL". Retrieved 2008-12-15.
3. ↑ Morgenstern C, Splith G (October 1965). "[Studies on the causes of gallamine tachycardia and its antagonistic modification by beta adrenolytics]". Der Anaesthesist (in German). 14 (10): 298–301. PMID 4380161. `|access-date=` requires `|url=` (help)CS1 maint: Unrecognized language (link)
4. ↑ WALTS LF (1963). "Ventricular tachycardia with gallamine and cyclopropane anesthesia". Anesthesiology. 24: 119. doi:10.1097/00000542-196301000-00024. PMID 13998750. Retrieved 2014-09-20.
5. ↑ Raghavendra T (July 2002). "Neuromuscular blocking drugs: discovery and development". J R Soc Med. 95 (7): 363–7. doi:10.1258/jrsm.95.7.363. PMC 1279945. PMID 12091515.

*[CID]: Compound ID