Gallbladder cancer classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]

## Overview

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Gallbladder cancer may be classified according to WHO into various subtypes like adenocarcinoma, papillary adenocarcinoma, mucinous adenocarcinoma, signet ring cell carcinoma, adenosquamous carcinoma, squamous cell carcinoma, neuroendocrine carcinoma, small cell carcinoma, undifferentiated carcinoma, spindle cell undifferentiated carcinoma, giant cell undifferentiated carcinoma.

## Classification

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Gallbladder carcinoma may be classified according to histology into following subtypes.[1]

SUBTYPE | HISTOLOGICAL FEATURES

|

Adenocarcinoma | Sheets, cohesive fragments, acini, and mucin
Papillary adenocarcinoma  | Pleomorphism and papillary fragments with vascular core
Mucinous adenocarcinoma  | Single cells or cluster and extracellular mucin
Signet ring cell carcinoma | Intracellular mucin with signet ring cells
Adenosquamous carcinoma | Mixture of glandular and squamous components
Squamous cell carcinoma | Necrosis, tadpole cells and atypical keratinized cells
Neuroendocrine carcinoma  | Salt and pepper chromatin,anisonucleosis and rosettes
Small cell carcinoma | Absent cytoplasm, Smudge cells, and mitoses
Undifferentiated carcinoma  | Pleomorphic cells, abundant necrosis
Spindle cell undifferentiated carcinoma  | Undifferciated type with prominent spindle cells
Gaint cell undifferentiated carcinoma  | Undifferentiated type with predominant giant cells

## References

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1. ↑ Jain, Deepali; Mathur, SandeepR; Sharma, Atul; Yadav, Rajni; Iyer, VenkateswaranK (2013). "Gallbladder carcinoma: An attempt of WHO histological classification on fine needle aspiration material". CytoJournal. 10 (1): 12. doi:10.4103/1742-6413.113627. ISSN 1742-6413.

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