Gem-associated protein 6

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Identifiers
Aliases|
External IDs| GeneCards: [1]
Orthologs
Species| Human| Mouse
Entrez| |

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Ensembl| |

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UniProt| |

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RefSeq (mRNA)| |

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RefSeq (protein)| |

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Location (UCSC)| n/a| n/a
PubMed search| n/a| n/a
Wikidata
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Gem-associated protein 6 is a protein that in humans is encoded by the GEMIN6 gene.[1][2]The gem-associated proteins are those found in the gems of Cajal bodies.

## Contents

* 1 Function
* 2 Interactions
* 3 References
* 4 Further reading

## Function

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GEMIN6 is part of a large macromolecular complex, the SMN localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM][2]

## Interactions

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Gem-associated protein 6 has been shown to interact with gem-associated protein 7.[3][4]

## References

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1. ↑ Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (Mar 2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". The Journal of Biological Chemistry. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
2. ↑ 2.0 2.1 "Entrez Gene: GEMIN6 gem (nuclear organelle) associated protein 6".
3. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
4. ↑ Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.

## Further reading

[edit | edit source]

* Baccon J, Pellizzoni L, Rappsilber J, Mann M, Dreyfuss G (Aug 2002). "Identification and characterization of Gemin7, a novel component of the survival of motor neuron complex". The Journal of Biological Chemistry. 277 (35): 31957–62. doi:10.1074/jbc.M203478200. PMID 12065586.
* Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (Jun 2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure. 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
* Carissimi C, Saieva L, Gabanella F, Pellizzoni L (Dec 2006). "Gemin8 is required for the architecture and function of the survival motor neuron complex". The Journal of Biological Chemistry. 281 (48): 37009–16. doi:10.1074/jbc.M607505200. PMID 17023415.

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PDB gallery

* 1y96: crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex

1y96: crystal structure of the Gemin6/Gemin7 heterodimer from the human SMN complex

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Structures of the cell nucleus / nuclear protein

Envelope (membrane)/
nuclear lamina|

* Pore complex:
* Nucleoporin
* NUP35
* NUP37
* NUP43
* NUP50
* NUP54
* NUP62
* NUP85
* NUP88
* NUP93
* NUP98
* NUP107
* NUP133
* NUP153
* NUP155
* NUP160
* NUP188
* NUP205
* NUP210
* NUP214
* AAAS

Nucleolus|

* Cajal (coiled) body
* SMN
* GEMIN2
* GEMIN4
* GEMIN5
* GEMIN6
* GEMIN7
* DDX20
* COIL
* Perinucleolar compartment
* PTBP1
* CUGBP1
* TCOF
* ATXN7

Other|

* Chromatin
* Dot (PML body)
* Paraspeckle

SMC protein:|

* Cohesin
* SMC1A
* SMC1B
* SMC3
* Condensin
* NCAPD2
* NCAPD3
* NCAPG
* NCAPG2
* NCAPH
* NCAPH2
* SMC2
* SMC4
* DNA repair
* SMC5
* SMC6

Transition nuclear protein:|

*     * TNP1
* TNP2

* Nuclear matrix (Nucleoskeleton)
* Nucleoplasm (Nucleosol)

* LITAF

* see also transcription factors and intracellular receptors

see also nucleus diseases

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