HCN3

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Identifiers
Aliases|
External IDs| GeneCards: [1]
Orthologs
Species| Human| Mouse
Entrez| |

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Ensembl| |

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UniProt| |

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RefSeq (mRNA)| |

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Location (UCSC)| n/a| n/a
PubMed search| n/a| n/a
Wikidata
| View/Edit Human|

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Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 is a protein that in humans is encoded by the HCN3 gene.[1][2]

## Contents

* 1 See also
* 2 References
* 3 Further reading
* 4 External links

## See also[edit | edit source]

* Cyclic nucleotide-gated ion channel

## References[edit | edit source]

1. ↑ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102.
2. ↑ "Entrez Gene: HCN3 hyperpolarization activated cyclic nucleotide-gated potassium channel 3".

## Further reading[edit | edit source]

* Santoro B, Grant SG, Bartsch D, Kandel ER (1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14815–20. doi:10.1073/pnas.94.26.14815. PMC 25120. PMID 9405696.
* Ludwig A, Zong X, Jeglitsch M, et al. (1998). "A family of hyperpolarization-activated mammalian cation channels". Nature. 393 (6685): 587–91. doi:10.1038/31255. PMID 9634236.
* Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
* Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
* Much B, Wahl-Schott C, Zong X, et al. (2003). "Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels". J. Biol. Chem. 278 (44): 43781–6. doi:10.1074/jbc.M306958200. PMID 12928435.
* Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
* Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
* Stieber J, Stöckl G, Herrmann S, et al. (2005). "Functional expression of the human HCN3 channel". J. Biol. Chem. 280 (41): 34635–43. doi:10.1074/jbc.M502508200. PMID 16043489.
* Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

## External links[edit | edit source]

* HCN3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

* v
* t
* e

Membrane transport protein: ion channels (TC 1A)

Ca2+: Calcium channel

| Ligand-gated|

* Inositol trisphosphate receptor
* 1
* 2
* 3
* Ryanodine receptor
* 1
* 2
* 3

|

Voltage-gated|

* L-type/Cavα
* 1.1
* 1.2
* 1.3
* 1.4
* N-type/Cavα2.2
* P-type/Cavα
* 2.1
* Q-type/Cavα2.1
* R-type/Cavα2.3
* T-type/Cavα
* 3.1
* 3.2
* 3.3

* α2δ-subunits
* 1
* 2
* β-subunits
* β1
* β2
* β3
* β4
* γ-subunits
* γ1
* γ2
* γ3
* γ4

* Cation channels of sperm
* 1
* 2
* 3
* 4
* Two-pore channel
* 1
* 2

Na+: Sodium channel

| Constitutively active|

* Epithelial sodium channel
* α
* β
* γ
* δ

|

Proton-gated|

* Amiloride-sensitive cation channel
* 1
* 2
* 3
* 4

Voltage-gated|

* Navα
* 1.1
* 1.2
* 1.3
* 1.4
* 1.5
* 1.6
* 1.7
* 1.8
* 1.9
* 7A
* Navβ
* 1
* 2
* 3
* 4

K+: Potassium channel

| Calcium-activated|

* BK channel
* α1
* β1
* β2
* β3
* β4
* SK channel
* SK1
* SK2
* SK3
* IK channel
* IK1
* KCa
* 1.1
* 2.1
* 2.2
* 2.3
* 3.1
* 4.1
* 4.2
* 5.1

|

Inward-rectifier|

* KATP
* Kir
* 1.1
* 2.1
* 2.2
* 2.3
* 2.4
* 2.6
* GIRK/Kir
* 3.1
* 3.2
* 3.3
* 3.4
* Kir
* 4.1
* 4.2
* 5.1
* 6.1
* 6.2
* 7.1

Tandem pore domain|

* K2P
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 9
* 10
* 12
* 13
* 15
* 16
* 17
* 18

Voltage-gated|

* Kvα1-6
* 1.1
* 1.2
* 1.3
* 1.4
* 1.5
* 1.6
* 1.7
* 1.8
*     * 2.1
* 2.2
*     * 3.1
* 3.2
* 3.3
* 3.4
*     * 4.1
* 4.2
* 4.3
*     * 5.1
*     * 6.1
* 6.2
* 6.3
* 6.4

* Kvα7-12
* 7.1
* 7.2
* 7.3
* 7.4
* 7.5
*     * 8.1
* 8.2
*     * 9.1
* 9.2
* 9.3
*     * 10.1
* 10.2
*     * 11.1/hERG
* 11.2
* 11.3
*     * 12.1
* 12.2
* 12.3

* Kvβ
* 1
* 2
* 3
* KCNIP
* 1
* 2
* 3
* 4
* minK/ISK
* minK/ISK-like
* MiRP
* 1
* 2
* 3
* Shaker gene

Miscellaneous

| Cl−: Chloride channel|

* Calcium-activated chloride channels
* Anoctamin
* ANO1
* Bestrophin
* 1
* 2
* Chloride Channel Accessory
* 1
* 2
* 3
* 4
* CFTR
* CLCN
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* KA
* KB
* CLIC
* 1
* 2
* 3
* 4
* 5
* 6
* L1
* CLNS
* 1A
* 1B

|

H+: Proton channel|

* HVCN1

M+: CNG cation channel|

* α
* 1
* 2
* 3
* 4
* β
* 1
* 2
* 3
* HCN
* FC
* 1
* 2
* 3
* 4

M+: TRP cation channel|

* TRPA (1)
* TRPC
* 1
* 2
* 3
* 4
* 4AP
* 5
* 6
* 7
* TRPM
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* TRPML
* 1
* 2
* 3
* TRPN
* TRPP
* 1
* 2
* TRPV
* 1
* 2
* 3
* 4
* 5
* 6

H2O (+ solutes): Porin|

* Aquaporin
* 0
* 1
* 2
* 3
* 4
* 5
* 6
* 7
* 8
* 9
* Voltage-dependent anion channel
* 1
* 2
* 3
* General bacterial porin family

Cytoplasm: Gap junction|

* Connexin
* A
* GJA1
* GJA3
* GJA4
* GJA5
* GJA8
* GJA9
* GJA10
* B
* GJB1
* GJB2
* GJB3
* GJB4
* GJB5
* GJB6
* GJB7
* C
* GJC1
* GJC2
* GJC3
* D
* GJD2
* GJD3
* GJD4
* Innexin

By gating mechanism

| Ion channel class|

* Ligand-gated
* Light-gated
* Voltage-gated
* Stretch-activated

|

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