Haemophilus b conjugate vaccine

HIBERIX® FDA Package Insert
Description
Clinical Pharmacology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Overdosage
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:  Chetan Lokhande, M.B.B.S [2]

## Overview

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Haemophilus influenzae type B vaccine (Hib janan or PRP vaccine[1]) is a conjugate vaccine developed for the prevention of invasive disease caused by Haemophilus influenzae type b bacteria. The Centers for Disease Control and Prevention (CDC) has recommended the use of the Hib vaccine.[2] Due to routine use of the Hib vaccine in the U.S. from 1980 to 1990, the incidence of invasive Hib disease has decreased from 40–100 per 100,000 children down to 1.3 per 100,000.[3] Vaccinations against Haemophilus influenzae (Hib) have decreased early childhood meningitis significantly in developed countries and recently in developing countries.[4]

## Category

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Vaccine

## US Brand Names

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HIBERIX®

## FDA Package Insert

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Description | Clinical Pharmacology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Overdosage | Dosage and Administration | How Supplied | Labels and Packages

## Mechanism of Action

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Although Hib vaccine is given to children, Hib infections have also decreased in adults. This decrease occurred because of herd immunity; children infected with Hib carry the bacteria in their nasal passages while clearing the infection. These Hib-carrying children would regularly infect adults. The practice of vaccinating children eliminated the source of the bacteria, reducing the rate of Hib in adults.

## References

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1. ↑ PMID 2107520 (PMID 2107520)
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2. ↑ "Recommendation of the Immunization Practices Advisory Committee (ACIP) Polysaccharide Vaccine for Prevention of Haemophilus influenzae Type b Disease". MMWR Weekly. 34 (15): 201–5. 1985-04-19. ISSN 0149-2195. Retrieved 2008-10-03.
3. ↑ "Haemophilus influenzae Serotype b (Hib) Disease". Disease Listing. Centers for Disease Control and Prevention. 2008-04-04. Retrieved 2008-10-03.
4. ↑ "Deadly Disease Eliminated in Children under Five Years of Age in Uganda" (Press release). GAVI Alliance. 2008-03-10. Retrieved 2008-10-03.