Hazardous drugs

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

## Overview

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In pharmacology, hazardous drugs are drugs that are known to cause genotoxicity, which is the ability to cause a change or mutation in genetic material; carcinogenicity, the ability to cause cancer in animal models, humans or both; teratogenicity, which is the ability to cause defects on fetal development or fetal malformation; and lastly hazardous drugs are known to have the potential to cause fertility impairment, which is a major concern for most clinicians.[1] These drugs can be classified as antineoplastics, cytotoxic agents, biologic agents, antiviral agents and immunosuppressive agents. This is why safe handling of hazardous drugs is crucial.

## Safe handling

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Safe handling refers to the process in which health care workers adhere to evidence-based practices (EBP) set forth by national organizations, that have been designed to eliminate or significantly reduce occupational exposure. Some of these practices include but are not limited to, donning of personal protective equipment such as a disposable gown, gloves, masks and the utilization of a closed-system drug transfer device. The key to safe handling is to protect the health care worker throughout the three phases of contact with the hazardous drugs. These phases are drug preparation, administration and disposal. Research has shown that while compounding hazardous drugs in a Class II BSC in conjunction with a closed-system drug transfer device, a significant decrease in drug contaminants inside a Class II BSC has resulted.[2] The Oncology Nursing Society (ONS) further elaborates on the topic of safe handling by stating that a closed-system drug transfer device is viewed as one of safest measures to prevent hazardous drug exposure from coming in contact with a clinician’s working environment.[3]

It has been determined that current personal protective equipment (PPE) does not provide adequate protection against workers handling hazardous drugs - NIOSH states that “... measurable concentrations of some hazardous drugs have been documented in the urine of health care workers who prepared or administered them − even after safety precautions had been employed.”[1] Further, NIOSH recommends that institutions should "consider using devices such as closed-system transfer devices. Closed systems limit the potential for generating aerosols and exposing workers".[1] Other guidelines outline that "As other products become available, they should meet the definition of a closed-system drug-transfer devices established by NIOSH and should be required to demonstrate their effectiveness in independent studies".[2]

## References

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1. ↑ 1.0 1.1 1.2 National Institute for Occupational Safety and Health (NIOSH). 2004. NIOSH Publication N. 2004-165 http://www.cdc.gov/niosh/docs/2004-165/
2. ↑ 2.0 2.1 American Society of Health-System Pharmacists (ASHP). 2005. Retrieved June 19, 2006, from http://www.ashp.org/
3. ↑ Oncology Nursing Society (ONS). 2003. Safe handling of hazardous drugs.

## Resources

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* American Society of Health-System Pharmacists (ASHP)
* National Institute for Occupational Safety and Health (NIOSH)
* Oncology Nursing Society (ONS)
* The International Agency for Research on Cancer (IARC) Classification of Hazardous Drugs